1.0 2016-09-30 22:33:13 UTC 2020-06-04 22:53:48 UTC BMDB0000588 BMDB00588 Sodium Sodium, also known as Na+ or sodium ion, belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Sodium exists as a solid, possibly soluble (in water), and possibly neutral molecule. Sodium exists in all living species, ranging from bacteria to humans. Na(+) Na+ SODIUM ion Sodium(1+) Na 22.9898 22.989769675 sodium(1+) ion sodium(1+) ion 17341-25-2 [Na+] InChI=1S/Na/q+1 FKNQFGJONOIPTF-UHFFFAOYSA-N belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Inorganic compounds Homogeneous metal compounds Homogeneous alkali metal compounds Homogeneous alkali metal compounds Homogeneous alkali metal a cation alkali metal cation elemental sodium monoatomic monocation monovalent inorganic cation Solid melting_point 97.82 °C logp -0.77 ChemAxon pka_strongest_acidic 3.09 ChemAxon iupac sodium(1+) ion ChemAxon average_mass 22.9898 ChemAxon mono_mass 22.989769675 ChemAxon smiles [Na+] ChemAxon formula Na ChemAxon inchi InChI=1S/Na/q+1 ChemAxon inchikey FKNQFGJONOIPTF-UHFFFAOYSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 0 ChemAxon polarizability 1.78 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 0 ChemAxon donor_count 0 ChemAxon physiological_charge 1 ChemAxon formal_charge 1 ChemAxon number_of_rings 0 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Kidney Function SMP0119376 Lactose Degradation SMP0087253 Muscle/Heart Contraction SMP0119378 Thyroid Hormone Synthesis SMP0087269 Trehalose Degradation SMP0087263 Specdb::MsMs 24779 Specdb::MsMs 24780 Specdb::MsMs 24781 Specdb::MsMs 31337 Specdb::MsMs 31338 Specdb::MsMs 31339 Specdb::MsMs 2911922 Specdb::MsMs 2911923 Specdb::MsMs 2911924 Blood 143000 uM Detected by Dacos Chemistry Analyzer in Hereford cows Early RJ, McBride BW, Ball RO: Growth and metabolism in somatotropin-treated steers: I. Growth, serum chemistry and carcass weights. J Anim Sci. 1990 Dec;68(12):4134-43. doi: 10.2527/1990.68124134x. 2286555 Blood 144500 +/- 260 uM McAdam PA, O'Dell GD: Mineral profile of blood plasma of lactating dairy cows. J Dairy Sci. 1982 Jul;65(7):1219-26. doi: 10.3168/jds.S0022-0302(82)82333-3. 7108016 Blood 142500 +/- 1110 uM Detected by Spectrometry (Autoanalyzer/BT3000 Plus) Abdullah BASOGLU, Nuri BASPINAR, Alparslan COSKUN. NMR-based metabolomic evaluation in dairy cows with displaced abomasum. Turk J Vet Anim Sci (2014) 38(3):325-330 Blood 133515 +/- 13658 uM By ICP-MS Aidin Foroutan, Carolyn Fitzsimmons, Rupasri Mandal, Hamed Piri‐Moghadam, Jiamin Zheng, AnChi Guo, Carin Li, Le Luo Guan and David S. Wishart. The Bovine Metabolome. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233 Kidney Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Liver 25588 +/- 4753 nmol/g of tissue By ICP-MS Aidin Foroutan, Carolyn Fitzsimmons, Rupasri Mandal, Hamed Piri‐Moghadam, Jiamin Zheng, AnChi Guo, Carin Li, Le Luo Guan and David S. Wishart. The Bovine Metabolome. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233 Longissimus Thoracis Muscle 10109 +/- 2109 nmol/g of tissue By ICP-MS Aidin Foroutan, Carolyn Fitzsimmons, Rupasri Mandal, Hamed Piri‐Moghadam, Jiamin Zheng, AnChi Guo, Carin Li, Le Luo Guan and David S. Wishart. The Bovine Metabolome. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233 Milk 17000 - 28000 uM Gaucheron F: The minerals of milk. Reprod Nutr Dev. 2005 Jul-Aug;45(4):473-83. doi: 10.1051/rnd:2005030. 16045895 Milk 25228.58 uM Park, Y. W; Juárez, Manuela ; Ramos, M.; Haenlein, G. F. W.. Physico-chemical characteristics of goat and sheep milk. Small Ruminant Res.(2007) 68:88-113 doi: 10.1016/j.smallrumres.2006.09.013 Milk 18703.947 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 19573.898 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 20008.874 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 20878.825 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 21313.8 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 21748.776 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 23053.702 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 25228.58 uM Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Milk 16345 +/- 1257 uM 1% milk by ICP-MS Foroutan A, Guo AC, Vazquez-Fresno R, Lipfert M, Zhang L, Zheng J, Badran H, Budinski Z, Mandal R, Ametaj BN, Wishart DS: Chemical Composition of Commercial Cow's Milk. J Agric Food Chem. 2019 Apr 17. doi: 10.1021/acs.jafc.9b00204. 30994344 Milk 16560 +/- 1174.25 uM 2% milk by ICP-MS Foroutan A, Guo AC, Vazquez-Fresno R, Lipfert M, Zhang L, Zheng J, Badran H, Budinski Z, Mandal R, Ametaj BN, Wishart DS: Chemical Composition of Commercial Cow's Milk. J Agric Food Chem. 2019 Apr 17. doi: 10.1021/acs.jafc.9b00204. 30994344 Milk 16197 +/- 1765 uM 3.25% milk by ICP-MS Foroutan A, Guo AC, Vazquez-Fresno R, Lipfert M, Zhang L, Zheng J, Badran H, Budinski Z, Mandal R, Ametaj BN, Wishart DS: Chemical Composition of Commercial Cow's Milk. J Agric Food Chem. 2019 Apr 17. doi: 10.1021/acs.jafc.9b00204. 30994344 Milk 15926 +/- 1396 uM Skim milk by ICP-MS Foroutan A, Guo AC, Vazquez-Fresno R, Lipfert M, Zhang L, Zheng J, Badran H, Budinski Z, Mandal R, Ametaj BN, Wishart DS: Chemical Composition of Commercial Cow's Milk. J Agric Food Chem. 2019 Apr 17. doi: 10.1021/acs.jafc.9b00204. 30994344 Milk 21313.800 - 22183.751 uM Gaucheron F: Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011 Oct;30(5 Suppl 1):400S-9S. 22081685 Milk 24793.604 uM Milk, filled, fluid, with blend of hydrogenated vegetable oils USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 24793.604 uM Milk, filled, fluid, with lauric acid oil USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 19138.922 uM Milk, fluid, 1% fat, without added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 22618.727 uM Milk, fluid, nonfat, calcium fortified (fat free or skim) USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 1304.927 uM Milk, low sodium, fluid USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 25228.58 uM Milk, lowfat, fluid, 1% milkfat, protein fortified, with added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 22618.727 uM Milk, lowfat, fluid, 1% milkfat, with added nonfat milk solids, vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 19138.922 uM Milk, lowfat, fluid, 1% milkfat, with added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 25663.555 uM Milk, nonfat, fluid, protein fortified, with added vitamin A and vitamin D (fat free and skim) USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 23053.702 uM Milk, nonfat, fluid, with added nonfat milk solids, vitamin A and vitamin D (fat free or skim) USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 18268.971 uM Milk, nonfat, fluid, with added vitamin A and vitamin D (fat free or skim) USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 18268.971 uM Milk, nonfat, fluid, without added vitamin A and vitamin D (fat free or skim) USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 18877.937 uM Milk, partly skim, conventional (not organic), 1.5 % fat Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 18877.937 uM Milk, partly skim, organic, 1.5 % fat Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 21313.8 uM Milk, producer, fluid, 3.7% milkfat USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 25663.555 uM Milk, reduced fat, fluid, 2% milkfat, protein fortified, with added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 22618.727 uM Milk, reduced fat, fluid, 2% milkfat, with added nonfat milk solids and vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 25663.555 uM Milk, reduced fat, fluid, 2% milkfat, with added nonfat milk solids, without added vitamin A USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 20443.849 uM Milk, reduced fat, fluid, 2% milkfat, with added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 20443.849 uM Milk, reduced fat, fluid, 2% milkfat, without added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 19269.415 uM Skim milk Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 19225.918 uM Milk, skim, 0.5 % fat Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 19269.415 uM Milk, skim, organic Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 18703.947 uM Milk, whole, 3.25% milkfat, with added vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 18703.947 uM Milk, whole, 3.25% milkfat, without added vitamin A and vitamin D USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Milk 18529.957 uM Milk, whole, 3.5, (UHT), % fat Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 19747.888 uM Milk, whole, conventional (not organic), 3.5 % fat Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Milk 19747.888 uM Milk, whole, organic, 3.5 % fat Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en Ruminal Fluid 235634 +/- 19788 uM By ICP-MS Aidin Foroutan, Carolyn Fitzsimmons, Rupasri Mandal, Hamed Piri‐Moghadam, Jiamin Zheng, AnChi Guo, Carin Li, Le Luo Guan and David S. Wishart. The Bovine Metabolome. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233 Ruminal Fluid 113362 +/- 3434 uM Samples have been collected from 8 healthy primiparous Holstein cow, no barley grains in diet. Metabolite measured by ICP-MS. Fozia Saleem, Souhaila Bouatra, An Chi Guo, Nikolaos Psychogios, Rupasri Mandal, Suzanna M. Dunn, Burim N. Ametaj, David S. Wishart. The Bovine Ruminal Fluid Metabolome. Metabolomics (2013) 9:360–378. Semimembranosus Muscle 12037 +/- 2852 nmol/g of tissue By ICP-MS Aidin Foroutan, Carolyn Fitzsimmons, Rupasri Mandal, Hamed Piri‐Moghadam, Jiamin Zheng, AnChi Guo, Carin Li, Le Luo Guan and David S. Wishart. The Bovine Metabolome. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233 Testis 35578 +/- 6600 nmol/g of tissue By ICP-MS Aidin Foroutan, Carolyn Fitzsimmons, Rupasri Mandal, Hamed Piri‐Moghadam, Jiamin Zheng, AnChi Guo, Carin Li, Le Luo Guan and David S. Wishart. The Bovine Metabolome. Metabolites 2020, 10, 233; doi:10.3390/metabo10060233 899 923 FDB031052 C01330 29101 37376 Sodium 3192 Gaucheron F: The minerals of milk. Reprod Nutr Dev. 2005 Jul-Aug;45(4):473-83. doi: 10.1051/rnd:2005030. 16045895 Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. 9718493 Gaucheron F: Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011 Oct;30(5 Suppl 1):400S-9S. 22081685 Park, Y. W; Juárez, Manuela ; Ramos, M.; Haenlein, G. F. W.. Physico-chemical characteristics of goat and sheep milk. Small Ruminant Res.(2007) 68:88-113 doi: 10.1016/j.smallrumres.2006.09.013 A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation) USDA Food Composition Databases: https://ndb.nal.usda.gov/ndb/ Fooddata+, The Technical University of Denmark (DTU): https://frida.fooddata.dk/QueryFood.php?fn=milk&lang=en BMDBP00145 Sodium/potassium-transporting ATPase subunit alpha-1 Q08DA1 ATP1A1 Enzyme BMDBP00158 Sodium/potassium-transporting ATPase subunit alpha-2 A2VDL6 ATP1A2 Enzyme BMDBP00472 DNA polymerase beta Q27958 POLB Enzyme BMDBP00966 Ubiquitin-conjugating enzyme E2 E3 Q2T9X7 UBE2E3 Enzyme BMDBP01006 Protein tyrosine phosphatase type IVA 3 A2VDT1 PTP4A3 Enzyme BMDBP01031 Sodium/potassium-transporting ATPase subunit beta-2 Q28030 ATP1B2 Enzyme BMDBP01032 Sodium/potassium-transporting ATPase subunit beta-3 Q3T0C6 ATP1B3 Enzyme BMDBP01033 Sodium/potassium-transporting ATPase subunit gamma Q04645 FXYD2 Enzyme BMDBP01610 Prostaglandin E2 receptor EP3 subtype P34979 PTGER3 Enzyme BMDBP01643 Solute carrier family 10 (Sodium/bile acid cotransporter family), member 4 A0JNQ1 SLC10A4 Enzyme BMDBP01849 SLC12A5 protein A8KC65 SLC12A5 Enzyme BMDBP01862 Na-K-Cl cotransporter O18978 Enzyme BMDBP01863 Sodium chloride cotransporter O97740 Enzyme BMDBP01874 Sodium/myo-inositol cotransporter 2 Q3ZC26 SLC5A11 Enzyme BMDBP01875 Na+/myo-inositol cotransporter O19135 Enzyme BMDBP01896 Sodium- and chloride-dependent creatine transporter 1 O18875 SLC6A8 Enzyme BMDBP02002 Sodium iodide symporter B6ZBT4 Enzyme BMDBP02003 Truncated sodium iodide symporter B2CSJ0 Enzyme BMDBP02085 Sodium-coupled neutral amino acid transporter 2 A2VE31 SLC38A2 Enzyme BMDBP02086 Solute carrier family 5 (Choline transporter), member 7 Q2KI26 SLC5A7 Enzyme BMDBP02092 Sodium-coupled neutral amino acid transporter 5 Q5E9S9 SLC38A5 Enzyme BMDBP02141 Solute carrier family 13 (Sodium-dependent dicarboxylate transporter), member 2 Q3SYV8 SLC13A2 Enzyme BMDBP02143 Solute carrier family 13 (Sodium-dependent dicarboxylate transporter), member 3 A1A4I3 SLC13A3 Enzyme BMDBP02149 Putative sodium-glucose cotransporter Q9TTR6 sglt1 Enzyme BMDBP02157 Na+/glucose cotransporter Q8MKB7 SGLT1 Enzyme BMDBP02158 Sodium-dependent glucose transporter SGLT-I Q95JG8 Enzyme BMDBP02173 Amiloride-sensitive sodium channel subunit alpha P55270 SCNN1A Enzyme BMDBP02261 Amiloride-sensitive sodium channel subunit beta A5D7U4 SCNN1B Enzyme BMDBP02262 Sodium channel subunit beta-4 Q08E08 SCN4B Enzyme BMDBP02263 Solute carrier family 10 (Sodium/bile acid cotransporter family), member 1 Q2KJ85 SLC10A1 Enzyme BMDBP02264 Sodium channel protein Q8WMP8 Enzyme BMDBP02265 Sodium-driven chloride bicarbonate exchanger Q32LP4 SLC4A10 Enzyme BMDBP02266 Sodium/calcium exchanger 1 P48765 SLC8A1 Enzyme BMDBP02267 Vesicular glutamate transporter 1 A4FV52 SLC17A7 Enzyme BMDBP02268 ATPase, Na+/K+ transporting, beta 1 polypeptide Q3ZCH8 ATP1B1 Enzyme BMDBP02269 Sodium/hydrogen exchanger 1 Q28036 SLC9A1 Enzyme BMDBP02270 Sodium-dependent phosphate transporter 2 A1A4I1 SLC20A2 Enzyme BMDBP02271 Electrogenic sodium bicarbonate cotransporter 1 Q9GL77 SLC4A4 Enzyme BMDBP02272 Sodium/hydrogen exchanger Q0VD46 SLC9A9 Enzyme BMDBP02273 Sodium proton exchanger O97738 Enzyme BMDBP02274 Solute carrier family 13 (Sodium/sulfate symporters), member 4 Q08E60 SLC13A4 Enzyme BMDBP02275 Sodium-coupled monocarboxylate transporter 2 A7MBD8 SLC5A12 Enzyme BMDBP02276 P3 protein Q0V8N6 SLC10A3 Enzyme BMDBP02277 Solute carrier family 5 (Sodium-dependent vitamin transporter), member 6 A1L530 SLC5A6 Enzyme BMDBP02278 Sodium/potassium/calcium exchanger 1 Q28139 SLC24A1 Enzyme BMDBP02279 Protein ATP1B4 A7MB71 ATP1B4 Enzyme BMDBP02280 Putative sodium-coupled neutral amino acid transporter 11 Q5EA97 SLC38A11 Enzyme BMDBP02281 Putative sodium-coupled neutral amino acid transporter 7 A7E3U5 SLC38A7 Enzyme BMDBP02282 Na+/glucose cotransporter 2 Q6XUI1 SLC5A2 Enzyme BMDBP02283 Sodium/potassium-transporting ATPase subunit beta A6QLL5 ATP1B2 Enzyme BMDBP02284 Sodium channel subunit beta-3 Q2KI11 SCN3B Enzyme BMDBP02285 Sodium/myo-inositol cotransporter P53793 SLC5A3 Enzyme BMDBP02286 Sodium channel subunit beta-1 Q17QN4 SCN1B Enzyme BMDBP02287 Vesicular glutamate transporter 2 A6QLI1 SLC17A6 Enzyme BMDBP02288 Sodium-dependent phosphate transport protein 3 Q32LF0 SLC17A2 Enzyme BMDBP02289 Sodium/glucose cotransporter 5 Q6R4Q5 SLC5A10 Enzyme BMDBP02290 Sodium-dependent phosphate transport protein 2B Q27960 SLC34A2 Enzyme BMDBP02291 Sodium channel modifier 1 Q3ZBR0 SCNM1 Enzyme BMDBP02292 Solute carrier family 10 member 6 A6QP84 SLC10A6 Enzyme BMDBP02293 Similar to solute carrier family 5 (Sodium/glucose cotransporter), member 1 Q2KJ00 LOC531152 Enzyme BMDBP02294 Sodium/hydrogen exchanger A7MB44 SLC9A6 Enzyme BMDBP02295 Sodium/hydrogen exchanger O97739 Enzyme BMDBP02296 Acid sensing ion channel subunit 2 Q0VC38 ASIC2 Enzyme BMDBP02297 Anion exchange protein B2NIZ2 SLC4A4 Enzyme