1.0 2016-09-30 22:40:48 UTC 2020-05-21 16:26:57 UTC BMDB0001078 BMDB01078 Mannose 6-phosphate Mannose 6-phosphate, also known as alpha-D-mannose-6-p or mannose 6-phosphate, belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Mannose 6-phosphate is possibly soluble (in water) and an extremely weak basic (essentially neutral) compound (based on its pKa). Mannose 6-phosphate exists in all eukaryotes, ranging from yeast to humans. Mannose 6-phosphate participates in a number of enzymatic reactions, within cattle. In particular, Mannose 6-phosphate can be converted into fructose 6-phosphate; which is catalyzed by the enzyme mannose 6-phosphate isomerase. In addition, Mannose 6-phosphate can be biosynthesized from D-mannose through the action of the enzyme hexokinase-1. In cattle, mannose 6-phosphate is involved in the metabolic pathway called the fructose and mannose degradation pathway. Mannose 6-phosphoric acid alpha-D-Mannose-6-p alpha-D-Mannose-6-phosphate alpha-delta-Mannose-6-p alpha-delta-Mannose-6-phosphate D-Mannose 6-phosphate delta-Mannose 6-phosphate Man-6-p Mannose-6-phosphate Mannose-6-phosphate dilithium salt Mannose-6-phosphate disodium salt Mannose-6-phosphate sodium salt, (D)-isomer C6H13O9P 260.1358 260.029718526 {[(2R,3S,4S,5S,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid mannose 6 phosphate 3672-15-9 O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6-/m1/s1 NBSCHQHZLSJFNQ-RWOPYEJCSA-N belongs to the class of organic compounds known as hexose phosphates. These are carbohydrate derivatives containing a hexose substituted by one or more phosphate groups. Organic compounds Organic oxygen compounds Organooxygen compounds Carbohydrates and carbohydrate conjugates Hexose phosphates Hemiacetals Hydrocarbon derivatives Monoalkyl phosphates Monosaccharide phosphates Organic oxides Oxacyclic compounds Oxanes Polyols Secondary alcohols Alcohol Aliphatic heteromonocyclic compound Alkyl phosphate Hemiacetal Hexose phosphate Hydrocarbon derivative Monoalkyl phosphate Monosaccharide phosphate Organic oxide Organic phosphoric acid derivative Organoheterocyclic compound Oxacycle Oxane Phosphoric acid ester Polyol Secondary alcohol Aliphatic heteromonocyclic compounds D-mannopyranose 6-phosphate Solid logp -2.06 ALOGPS logs -0.92 ALOGPS logp -3.1 ChemAxon pka_strongest_acidic 1.22 ChemAxon pka_strongest_basic -3.6 ChemAxon iupac {[(2R,3S,4S,5S,6R)-3,4,5,6-tetrahydroxyoxan-2-yl]methoxy}phosphonic acid ChemAxon average_mass 260.1358 ChemAxon mono_mass 260.029718526 ChemAxon smiles O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O ChemAxon formula C6H13O9P ChemAxon inchi InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6-/m1/s1 ChemAxon inchikey NBSCHQHZLSJFNQ-RWOPYEJCSA-N ChemAxon polar_surface_area 156.91 ChemAxon refractivity 46.8 ChemAxon polarizability 20.99 ChemAxon rotatable_bond_count 3 ChemAxon acceptor_count 8 ChemAxon donor_count 6 ChemAxon physiological_charge -2 ChemAxon formal_charge 0 ChemAxon number_of_rings 1 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Fructose and Mannose Degradation SMP0087197 Specdb::NmrTwoD 1583 Specdb::CMs 3172 Specdb::CMs 37918 Specdb::CMs 135604 Specdb::CMs 143338 Specdb::MsMs 1418 Specdb::MsMs 1419 Specdb::MsMs 1420 Specdb::MsMs 179616 Specdb::MsMs 179617 Specdb::MsMs 179618 Specdb::MsMs 181947 Specdb::MsMs 181948 Specdb::MsMs 181949 Specdb::MsMs 3044605 Specdb::MsMs 3044606 Specdb::MsMs 3044607 Specdb::MsMs 3099154 Specdb::MsMs 3099155 Specdb::MsMs 3099156 Specdb::NmrOneD 1642 Specdb::NmrOneD 284029 Specdb::NmrOneD 284030 Specdb::NmrOneD 284031 Specdb::NmrOneD 284032 Specdb::NmrOneD 284033 Specdb::NmrOneD 284034 Specdb::NmrOneD 284035 Specdb::NmrOneD 284036 Specdb::NmrOneD 284037 Specdb::NmrOneD 284038 Specdb::NmrOneD 284039 Specdb::NmrOneD 284040 Specdb::NmrOneD 284041 Specdb::NmrOneD 284042 Specdb::NmrOneD 284043 Specdb::NmrOneD 284044 Specdb::NmrOneD 284045 Specdb::NmrOneD 284046 Specdb::NmrOneD 284047 Specdb::NmrOneD 284048 Fibroblasts Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Intestine Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Liver Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Prostate Tissue Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Spleen Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 Testis Wishart DS, Feunang YD, Marcu A, Guo AC, Liang K, Vazquez-Fresno R, Sajed T, Johnson D, Li C, Karu N, Sayeeda Z, Lo E, Assempour N, Berjanskii M, Singhal S, Arndt D, Liang Y, Badran H, Grant J, Serra-Cayuela A, Liu Y, Mandal R, Neveu V, Pon A, Knox C, Wilson M, Manach C, Scalbert A: HMDB 4.0: the human metabolome database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D608-D617. doi: 10.1093/nar/gkx1089. 29140435 C00275 FDB022411 388338 439198 49728 34471 Mannose 6-phosphate 5987 Pascual, C.; Herrera, L. Use of permeabilized yeast cells as a system of enzyme immobilization. Its use for the preparation of mannose 6-phosphate. Folia Microbiologica (Prague, Czech Republic) (1981), 26(2), 103-6. BMDBP00912 Hexokinase-1 P27595 HK1 Enzyme BMDBP01106 Mannose-6-phosphate isomerase Q3SZI0 MPI Enzyme BMDBP01128 Phosphomannomutase 2 Q3SZJ9 PMM2 Enzyme BMDBP01899 Cation-dependent mannose-6-phosphate receptor P11456 M6PR Enzyme BMDBP01906 Perilipin Q3SX32 PLIN3 Enzyme BMDBP01911 Cation-independent mannose-6-phosphate receptor P08169 IGF2R Enzyme