1.0 2016-09-30 23:26:58 UTC 2020-05-21 16:28:45 UTC BMDB0006868 BMDB06868 S-(2-Methylpropionyl)-dihydrolipoamide-E S-(2-Methylpropionyl)-dihydrolipoamide-e belongs to the class of organic compounds known as fatty amides. These are carboxylic acid amide derivatives of fatty acids, that are formed from a fatty acid and an amine. Thus, S-(2-methylpropionyl)-dihydrolipoamide-e-e is considered to be a fatty amide lipid molecule. S-(2-Methylpropionyl)-dihydrolipoamide-e is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. S-(2-Methylpropionyl)-dihydrolipoamide-e participates in a number of enzymatic reactions, within cattle. In particular, S-(2-Methylpropionyl)-dihydrolipoamide-e can be biosynthesized from 2-methyl-1-hydroxypropyl-THPP through the action of the enzymes 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial and 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. In addition, S-(2-Methylpropionyl)-dihydrolipoamide-e can be biosynthesized from lipoamide through the action of the enzymes 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial and 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial. In cattle, S-(2-methylpropionyl)-dihydrolipoamide-e-e is involved in the metabolic pathway called the valine, leucine, and isoleucine degradation pathway. S-(2-Methylpropanoyl)-dihydrolipoamide S-(2-Methylpropionyl)-dihydrolipoamide S-(2-Methylpropanoyl)-dihydrolipoamide-e [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]S-(2-methylpropanoyl)dihydrolipoyllysine C12H23NO2S2 277.447 277.117020365 8-[(2-methylpropanoyl)sulfanyl]-6-sulfanyloctanamide 8-[(2-methylpropanoyl)sulfanyl]-6-sulfanyloctanamide CC(C)C(=O)SCCC(S)CCCCC(N)=O InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) UEFURMXXHJCLJP-UHFFFAOYSA-N belongs to the class of organic compounds known as fatty amides. These are carboxylic acid amide derivatives of fatty acids, that are formed from a fatty acid and an amine. Organic compounds Lipids and lipid-like molecules Fatty Acyls Fatty amides Fatty amides Alkylthiols Carbonyl compounds Carbothioic S-esters Hydrocarbon derivatives Organic oxides Organonitrogen compounds Organopnictogen compounds Primary carboxylic acid amides Sulfenyl compounds Thioesters Aliphatic acyclic compound Alkylthiol Carbonyl group Carbothioic s-ester Carboxamide group Carboxylic acid derivative Fatty amide Hydrocarbon derivative Organic nitrogen compound Organic oxide Organic oxygen compound Organonitrogen compound Organooxygen compound Organopnictogen compound Organosulfur compound Primary carboxylic acid amide Sulfenyl compound Thiocarboxylic acid ester Thiocarboxylic acid or derivatives Aliphatic acyclic compounds S-substituted dihydrolipoamide Solid logp 3.05 ALOGPS logs -4.25 ALOGPS logp 2.48 ChemAxon pka_strongest_acidic 10.06 ChemAxon pka_strongest_basic -0.58 ChemAxon iupac 8-[(2-methylpropanoyl)sulfanyl]-6-sulfanyloctanamide ChemAxon average_mass 277.447 ChemAxon mono_mass 277.117020365 ChemAxon smiles CC(C)C(=O)SCCC(S)CCCCC(N)=O ChemAxon formula C12H23NO2S2 ChemAxon inchi InChI=1S/C12H23NO2S2/c1-9(2)12(15)17-8-7-10(16)5-3-4-6-11(13)14/h9-10,16H,3-8H2,1-2H3,(H2,13,14) ChemAxon inchikey UEFURMXXHJCLJP-UHFFFAOYSA-N ChemAxon polar_surface_area 60.16 ChemAxon refractivity 76.43 ChemAxon polarizability 32.12 ChemAxon rotatable_bond_count 10 ChemAxon acceptor_count 2 ChemAxon donor_count 2 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon number_of_rings 0 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Valine, Leucine, and Isoleucine Degradation SMP0087234 Specdb::CMs 25725 Specdb::CMs 148012 Specdb::MsMs 323005 Specdb::MsMs 323006 Specdb::MsMs 323007 Specdb::MsMs 371065 Specdb::MsMs 371066 Specdb::MsMs 371067 Specdb::MsMs 2734604 Specdb::MsMs 2734605 Specdb::MsMs 2734606 Specdb::MsMs 2973942 Specdb::MsMs 2973943 Specdb::MsMs 2973944 FDB024124 10128135 11953835 C04424 17577 BMDBP00637 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial P11178 BCKDHA Enzyme BMDBP00638 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial P21839 BCKDHB Enzyme BMDBP00786 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial P11181 DBT Enzyme