1.0 2018-10-03 16:32:54 UTC 2020-06-04 18:57:41 UTC BMDB0063606 BMDB63606 delta-Hexachlorocyclohexane Delta-hexachlorocyclohexane (delta-HCH) is a solid. It is a component of technical grade HCH. The interaction of delta-HCH with human red blood cells disrupts membrane structure and changes the environment of cytoskeleton proteins that could cause cell lysis. No neoplastic or nonneoplastic effects were noted in livers of male mice or rats given dietary delta-HCH at concentrations ranging from 100-1000 ppm. delta-HCH was particularly potent toward disrupting Ca2+ homeostasis in a variety of excitable and nonexcitable cells and altering contractility of cardiac muscle. delta-HCH interacts with cardiac ryanodine-sensitive Ca2+ channels (RyR2), accounting in part for altered Ca2+ transients and contractility. delta-HCH increases the ionic permeability of phospholipid membranes by two distinct Ca2+-dependent mechanisms: one mediated through RyR and the other mediated by a unique ionophore activity. (1alpha,2alpha,3alpha,4beta,5alpha,6beta)-1,2,3,4,5,6-Hexachlorocyclohexane (1R,2C,3C,4t,5C,6t)-1,2,3,4,5,6-Hexachlorocyclohexane delta-Benzene hexachloride delta-BHC delta-Lindane (1a,2a,3a,4b,5a,6b)-1,2,3,4,5,6-Hexachlorocyclohexane (1Α,2α,3α,4β,5α,6β)-1,2,3,4,5,6-hexachlorocyclohexane Δ-benzene hexachloride Δ-BHC Δ-lindane Δ-hexachlorocyclohexane C6H6Cl6 290.83 287.860066434 (1R,2S,3r,4R,5S,6s)-1,2,3,4,5,6-hexachlorocyclohexane delta-BHC 319-86-8 [H][C@]1(Cl)[C@]([H])(Cl)[C@@]([H])(Cl)[C@]([H])(Cl)[C@]([H])(Cl)[C@]1([H])Cl InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5-,6- JLYXXMFPNIAWKQ-GPIVLXJGSA-N belongs to the class of organic compounds known as cyclohexyl halides. These are organohalogen compounds containing a monocyclic cyclohexane moiety that is substituted at one or more positions by an halogen atom. Organic compounds Organohalogen compounds Alkyl halides Cyclohexyl halides Cyclohexyl halides Alkyl chlorides Hydrocarbon derivatives Organochlorides Aliphatic homomonocyclic compound Alkyl chloride Cyclohexyl halide Hydrocarbon derivative Organochloride Aliphatic homomonocyclic compounds hexachlorocyclohexane logp 3.94 ALOGPS logs -4.73 ALOGPS logp 4.35 ChemAxon iupac (1R,2S,3r,4R,5S,6s)-1,2,3,4,5,6-hexachlorocyclohexane ChemAxon average_mass 290.83 ChemAxon mono_mass 287.860066434 ChemAxon smiles [H][C@]1(Cl)[C@]([H])(Cl)[C@@]([H])(Cl)[C@]([H])(Cl)[C@]([H])(Cl)[C@]1([H])Cl ChemAxon formula C6H6Cl6 ChemAxon inchi InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4+,5-,6- ChemAxon inchikey JLYXXMFPNIAWKQ-GPIVLXJGSA-N ChemAxon polar_surface_area 0 ChemAxon refractivity 54.08 ChemAxon polarizability 23.39 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 0 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon number_of_rings 1 ChemAxon bioavailability 1 ChemAxon rule_of_five Yes ChemAxon ghose_filter Yes ChemAxon veber_rule Yes ChemAxon mddr_like_rule Yes ChemAxon Specdb::MsMs 93267 Specdb::MsMs 93268 Specdb::MsMs 93269 Specdb::MsMs 157008 Specdb::MsMs 157009 Specdb::MsMs 157010 Milk 0.00138 +/- 0.00413 uM Raw bovine milk from Haryana (n=147) Sharma HR, Kaushik A, Kaushik CP: Pesticide residues in bovine milk from a predominantly agricultural state of Haryana, India. Environ Monit Assess. 2007 Jun;129(1-3):349-57. doi: 10.1007/s10661-006-9368-5. Epub 2006 Dec 16. 17180431 39095 Sharma HR, Kaushik A, Kaushik CP: Pesticide residues in bovine milk from a predominantly agricultural state of Haryana, India. Environ Monit Assess. 2007 Jun;129(1-3):349-57. doi: 10.1007/s10661-006-9368-5. Epub 2006 Dec 16. 17180431