Coat colour, roan
Phenotype Details
- Phene ID
- 2101
- Name
- Coat colour, roan
- Phene Name
- N/A
- OMIA ID
- 1216
- Species ID
- 9913
- Characterised
- Yes
- Characterised Year
- 1999
Linked Genes
| Symbol | Gene ID | Chromosome | Description |
|---|---|---|---|
| KITLG | 281885 | 5 | KIT ligand |
Linked Variants
| Variant ID | Phenotype | Gene ID | Deleterious | Chromosome | Genomic | Transcript | Protein |
|---|---|---|---|---|---|---|---|
| 186 | Roan | 281885 | 0 | 5 | NC_037332.1:18262908G>T | NM_174375.2:c.653C>A | NP_776800.1:p.(A218D) |
Linked Breeds
| Breed | Breed ID | Species ID | VBO Term |
|---|---|---|---|
| Belgian Blue (Cattle) | 49 | 9913 | http://purl.obolibrary.org/obo/VBO_0000139 |
| Shorthorn (Cattle) | 76 | 9913 | http://purl.obolibrary.org/obo/VBO_0000375 |
Molecular Genetics
By cloning and sequencing a very likely comparative positional candidate gene (see the Genetic mapping section above), Seitz et al. (1999) reported that a missense mutation at 654 bp (amino acid 193, Ala>Asp) in the mast cell growth factor (MGF) locus is responsible for the roan phenotype in Belgian Blue and Shorthorn cattle (Mohammad Shariflou. The MGF gene is now called KITLG (10/11/2006; FN 15/9/2012)
Genetic Test
A PCR-RFLP was reported by Seitz et al. (1999).