Sterile, male, NANOS2-related
Phenotype Details
- Phene ID
- 4459
- Name
- Sterile, male, NANOS2-related
- Phene Name
- N/A
- OMIA ID
- 2311
- Species ID
- 9913
- Characterised
- No
- Characterised Year
- N/A
Summary
Ciccarelli et al. (2020) "show that male mice, pigs, goats, and cattle harboring knockout alleles of the NANOS2 gene generated by CRISPR-Cas9 editing have testes that are germline ablated but otherwise structurally normal. ... Collectively, these advancements represent a major step toward realizing the enormous potential of surrogate sires as a tool for dissemination and regeneration of germplasm in all mammalian species." These are genetically-modified organisms (GMO).