Fecundity, SMAD6-related
Phenotype Details
- Phene ID
- 5295
- Name
- Fecundity, SMAD6-related
- Phene Name
- Trio
- OMIA ID
- 2675
- Species ID
- 9913
- Characterised
- No
- Characterised Year
- N/A
Summary
Constantino et al. (2023): "The bovine high fecundity allele, Trio, causes overexpression in granulosa cells of SMAD6, an inhibitor of BMP15-activated SMAD signalling. Furthermore, the Trio allele results in antral follicles that develop slower, acquire ovulatory capacity at smaller sizes, and have 3-fold greater ovulation rate compared to half-sib non-carriers."
Genetic Test
Kirkpatrick and Morris (2015) identified "three polymorphisms were identified that can be used as a haplotype to track inheritance of the high ovulation rate allele in descendants of the carrier sire."