Sterile, NANOS3-related
Phenotype Details
- Phene ID
- 5759
- Name
- Sterile, NANOS3-related
- Phene Name
- N/A
- OMIA ID
- 2674
- Species ID
- 9913
- Characterised
- No
- Characterised Year
- N/A
Summary
Mueller et al. (2023) "generated NANOS3 KO [knock-out] cattle via cytoplasmic microinjection of the CRISPR/Cas9 system in vitro produced bovine zygotes and evaluated the effect of NANOS3 elimination on bovine germline development, from fetal development through reproductive age. ... Overall, this study demonstrated that the absence of NANOS3 in cattle leads to the specific deficiency of both male and female germ cells, suggesting the potential of NANOS3 KO cattle to act as hosts for donor-derived exogenous germ cell production in both sexes." This phene includes references to studies involving gene edited or genetically modified organisms (GMO).