Lethality, embryonic, POU5F1-related
Phenotype Details
- Phene ID
- 5889
- Name
- Lethality, embryonic, POU5F1-related
- Phene Name
- N/A
- OMIA ID
- 2832
- Species ID
- 9913
- Characterised
- Yes
- Characterised Year
- 2024
Summary
Nix et al. (2024) used gene editing in a mechanistic study of gene function of OCT4 (also called POU5F1). The authors "aimed to improve the efficiency of biallelic deletions and deplete specific maternal RNAs in cattle zygotes using CRISPR-Cas editing technology. ... The results confirm that OCT4 is a key regulator of genes that modulate pluripotency and is required to form a functional blastocyst in cattle."