| Identification |
|---|
| BMDB Protein ID
| BMDBP00016 |
| Secondary Accession Numbers
| None |
| Name
| Cytochrome P450 3A28 |
| Synonyms
|
Not Available
|
| Gene Name
| CYP3A28 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Secondary metabolites biosynthesis, transport and catabolism |
| Specific Function
| Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. |
| Pathways
|
- Arachidonic Acid Metabolism
- Bile Acid Biosynthesis
- Caffeine Metabolism
- Estrone Metabolism
- Retinol Metabolism
|
| Reactions
|
| 6-trans-Leukotriene B4 + NADPH + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water |
details
|
| Arachidonic acid + NADPH + Oxygen → 20-Hydroxyeicosatetraenoic acid + NADP + Water |
details
|
| Cholesterol + NADPH + Oxygen → 24-Hydroxycholesterol + NADP + Water |
details
|
| Retinoic acid → all-trans-5,6-Epoxyretinoic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CYP3A28 |
| Gene Sequence
|
>1524 bp
ATGGAACTGATCCCAAGCTTTTCCATGGAAACCTGGGTTCTCCTAGCTACCAGCCTGGTG
CTCCTCTATATATATGGGACTTATTCATATGGACTTTTTAAGAAGCTGGGGATTCCTGGG
CCAAGACCTGTGCCCTATTTTGGAAGTACTATGGCTTACCACAAGGGTATTCCAGAGTTT
GACAATCAGTGTTTTAAAAAGTATGGGAAAATGTGGGGGTTTTATGAAGGTCGACAACCT
ATGTTGGCTATCACAGATCCTGATATAATCAAAACAGTACTAGTGAAAGAATGTTATTCT
GTCTTCACAAACCGGAGGATTTTTGGTCCAATGGGAATTATGAAATATGCCATCTCTCTG
GCTTGGGATGAACAATGGAAGAGAATACGGACATTGCTGTCTCCAGCCTTCACCAGCGGA
AAGCTCAAGGAGATGTTCCCCATCATTGGCCAGTATGGAGATATGTTGGTGAGGAACCTG
AGGAAGGAAGCAGAGAAAGGCAATCCCGTCAACATGAAAGACATGTTTGGAGCCTACAGC
ATGGATGTGATTACTGGCACAGCATTTGGAGTGAATATTGATTCCCTCAACAACCCACAC
GATCCCTTTGTGGAACATAGCAAGAACCTCTTAAGATTTAGACCCTTCGATCCATTCATT
CTTTCAATAATATTATTTCCATTTCTCAACCCAGTTTTTGAAATATTAAACATTACTCTG
TTTCCAAAAAGTACTGTGGACTTTTTCACAAAATCTGTAAAGAAGATTAAAGAAAGTCGC
CTCACAGATAAACAAATGAATCGAGTGGATTTACTTCAGCTAATGATTAATTCTCAGAAT
TCCAAAGAAATTGACAACCATAAAGCTCTGTCTGACATAGAACTCGTGGCCCAAAGTACT
ATCTTTATTTTTGGTGGCTATGAGACCACTAGCAGTACTCTTTCCTTCATTATATATGAA
TTGACCACTCACCCTCATGTCCAGCAGAAGCTGCAGGAGGAAATTGATGCAACTTTCCCT
AATAAGGCCCCTCCCACCTACGATGCCCTGGTGCAGATGGAGTATCTTGACATGGTGGTG
AATGAGACTCTGAGAATGTTTCCAATTGCTGGGAGACTTGAGAGGGTCTGTAAGAAGGAT
GTGGAAATCCACGGGGTGACCATTCCCAAAGGGACAACCGTGCTGGTGCCACTCTTCGTT
CTTCACAACAACCCAGAGCTCTGGCCAGAGCCCGAGGAGTTCCGTCCCGAAAGGTTCAGT
AAGAATAACAAGGACAGCATAAATCCTTACGTCTACCTGCCTTTTGGAACTGGACCCCGA
AACTGCCTTGGCATGAGGTTTGCCATCATGAACATAAAACTTGCTCTTGTCAGAATCCTG
CAGAACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCCTGAAATTATACACTCAA
GGACTCACGCAGCCAGAACAACCTGTTATTCTGAAGGTTGTGCCCAGAGGCCTGGGACCA
CAGGTGGAGCCTGACTTTCTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 507 |
| Molecular Weight
| 58152.0 |
| Theoretical pI
| 8.93 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytochrome P450 3A28
MELIPSFSMETWVLLATSLVLLYIYGTYSYGLFKKLGIPGPRPVPYFGSTMAYHKGIPEF
DNQCFKKYGKMWGFYEGRQPMLAITDPDIIKTVLVKECYSVFTNRRIFGPMGIMKYAISL
AWDEQWKRIRTLLSPAFTSGKLKEMFPIIGQYGDMLVRNLRKEAEKGNPVNMKDMFGAYS
MDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSIILFPFLNPVFEILNITL
FPKSTVDFFTKSVKKIKESRLTDKQMNRVDLLQLMINSQNSKEIDNHKALSDIELVAQST
IFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNKAPPTYDALVQMEYLDMVV
NETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPERFS
KNNKDSINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQIPLKLYTQ
GLTQPEQPVILKVVPRGLGPQVEPDFL
|
| External Links |
|---|
| GenBank ID Protein
| CAA71266.1 |
| UniProtKB/Swiss-Prot ID
| P79102 |
| UniProtKB/Swiss-Prot Entry Name
| CP3AS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y10214 |
| GeneCard ID
| CYP3A28 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
