1.0 2018-05-07 22:20:28 UTC 2020-05-20 21:05:16 UTC BMDBP00022 Enzyme NOS3 Inorganic ion transport and metabolism Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. Arginine and Proline Metabolism SMP0087178 Ion Channels and Their Functional Role in Vascular Endothelium SMP0108207 Nitric Oxide Signaling Pathway SMP0108206 Succinate Signalling During Inflammation SMP0120886 BMDB0000027 Tetrahydrobiopterin BMDB0000217 NADP BMDB0000221 NADPH BMDB0000517 L-Arginine BMDB0000692 Iron BMDB0000902 NAD BMDB0000904 Citrulline BMDB0001248 FAD BMDB0003178 Heme BMDB0003378 Nitric oxide BMDB0001377 Oxygen BMDB0004224 N-(o)-Hydroxyarginine BMDB0002111 Water 4 >3618 bp ATGGGCAACTTGAAGAGTGTGGGCCAGGAGCCCGGGCCCCCCTGCGGCCTGGGGCTGGGG CTGGGCCTCGGGCTATGCGGCAAGCAGGGCCCAGCCTCCCCGGCACCTGAGCCCAGCCGG GCCCCCGCACCCGCCACCCCGCACGCGCCAGACCACAGCCCAGCTCCCAACAGCCCCACG CTGACCCGGCCTCCGGAGGGGCCCAAGTTCCCTCGCGTGAAGAACTGGGAGCTGGGGAGC ATCACCTACGACACTCTGTGCGCGCAGTCCCAACAGGACGGGCCCTGCACTCCCAGGTGC TGCCTGGGCTCCCTGGTGTTGCCCCGGAAACTGCAGACCCGGCCCTCCCCGGGACCTCCA CCCGCTGAGCAGCTGCTGAGCCAGGCCAGGGACTTCATCAACCAGTACTACAGCTCCATC AAGAGGAGCGGCTCCCAGGCTCACGAGGAGCGGCTTCAGGAGGTGGAGGCCGAGGTGGCA TCCACGGGCACCTACCACCTCCGAGAGAGCGAGCTGGTGTTCGGGGCCAAGCAGGCCTGG CGCAACGCACCCCGCTGCGTGGGCCGCATCCAGTGGGGGAAGCTGCAGGTGTTTGATGCC CGGGACTGCAGCTCAGCACAGGAGATGTTCACCTACATCTGCAACCACATCAAGTACGCC ACCAACCGCGGCAACCTTCGCTCGGCCATCACAGTGTTCCCGCAGCGCGCCCCGGGCCGC GGAGACTTCCGGATCTGGAACAGCCAGCTGGTGCGCTACGCAGGCTACAGACAGCAGGAT GGCTCTGTGCGTGGGGACCCAGCCAATGTGGAGATCACGGAGCTCTGCATCCAGCACGGC TGGACCCCCGGAAACGGCCGCTTCGACGTGCTGCCCCTGCTGCTCCAGGCCCCAGACGAG GCTCCAGAGCTCTTTGTTCTGCCCCCCGAGCTGGTCCTTGAAGTGCCCCTGGAGCACCCC ACACTGGAGTGGTTCGCGGCCCTGGGCCTGCGATGGTATGCCCTCCCGGCCGTGTCCAAC ATGCTGCTGGAAATCGGGGGTCTGGAGTTCTCCGCGGCCCCCTTCAGCGGCTGGTACATG AGCACGGAGATTGGCACGCGGAACCTGTGTGACCCTCACCGCTACAATATCCTGGAGGAT GTGGCCGTCTGCATGGACCTCGACACGCGGACCACCTCGTCCCTGTGGAAGGACAAGGCG GCCGTGGAGATCAACCTGGCTGTGCTGCACAGCTTTCAGCTCGCCAAGGTGACCATCGTG GACCACCACGCCGCCACGGTGTCCTTCATGAAGCACCTGGACAACGAGCAGAAGGCCAGG GGGGGCTGCCCCGCCGACTGGGCCTGGATCGTGCCCCCCATCTCAGGCAGCCTCACGCCC GTCTTCCACCAGGAGATGGTCAACTACATCCTGTCCCCTGCCTTCCGCTACCAGCCAGAC CCCTGGAAAGGGAGCGCGACCAAGGGCGCAGGCATCACCAGGAAGAAGACCTTTAAGGAA GTGGCCAACGCGGTGAAGATCTCTGCCTCACTCATGGGCACCCTGATGGCCAAGCGAGTG AAAGCAACCATCCTGTACGCCTCTGAGACCGGCCGGGCCCAGAGCTACGCTCAGCAGCTG GGGAGGCTCTTCCGGAAGGCCTTCGATCCCCGGGTCCTGTGCATGGATGAGTATGACGTG GTGTCCCTGGAGCACGAGGCGCTGGTACTGGTGGTGACCAGCACCTTTGGGAATGGCGAT CCCCCGGAGAATGGAGAGAGTTTTGCAGCTGCCCTGATGGAGATGTCGGGGCCCTACAAC AGCTCCCCGCGGCCGGAACAGCACAAGAGTTACAAGATCCGCTTCAACAGCGTCTCCTGC TCAGACCCGCTGGTGTCCTCCTGGCGGCGGAAGAGAAAGGAGTCCAGCAACACAGACAGT GCGGGGGCCCTGGGGACCCTCAGGTTCTGTGTGTTCGGACTGGGCTCCCGGGCATACCCC CACTTCTGCGCCTTCGCGCGAGCGGTGGACACCCGGCTGGAAGAGCTTGGAGGGGAGCGG CTGCTGCAGCTGGGCCAGGGCGATGAGCTCTGCGGCCAGGAAGAGGCCTTCCGTGGTTGG GCAAAGGCGGCCTTCCAGGCCTCCTGTGAGACCTTCTGCGTTGGGGAGGAGGCCAAGGCC GCCGCCCAGGACATCTTCAGCCCCAAACGGAGCTGGAAACGCCAGAGGTACCGGCTGAGC ACCCAGGCCGAGGGCCTCCAGCTGCTGCCAGGCCTGATCCACGTGCACAGACGGAAGATG TTTCAGGCCACAGTCCTCTCGGTGGAAAATCTGCAAAGCAGCAAGTCCACCCGGGCCACC ATCCTGGTGCGCCTGGACACTGCAGGCCAGGAGGGGCTGCAGTACCAGCCGGGGGACCAC ATAGGCATCTGCCCGCCCAACCGGCCGGGCCTGGTGGAGGCGCTGCTGAGCCGCGTGGAG GACCCGCCACCGCCCACCGAGTCTGTGGCTGTGGAGCAGCTGGAGAAAGGCAGCCCAGGC GGCCCTCCTCCCAGCTGGGTGCGGGACCCACGGCTGCCCCCGTGCACGCTGCGCCAGGCT CTCACCTTCTTCCTGGACATCACCTCCCCACCCAGCCCCCGGCTTCTCCGACTGCTCAGC ACCCTGGCCGAAGAACCCAGCGAGCAGCAGGAGCTTGAGACCCTCAGTCAGGACCCCCGG CGCTACGAGGAGTGGAAGTGGTTCCGCTGCCCCACGCTGCTGGAGGTGCTGGAGCAGTTC CCGTCCGTGGCGCTGCCCGCCCCGCTGCTCCTCACCCAGCTGCCCCTGCTGCAGCCCCGG TACTACTCTGTCAGCTCGGCCCCCAACGCCCACCCCGGAGAGGTCCACCTCACAGTGGCC GTGCTGGCGTACAGGACCCAAGATGGGCTGGGCCCCCTACACTACGGGGTCTGCTCCACA TGGCTGAGCCAGCTCAAGACTGGAGACCCCGTGCCCTGCTTCATCAGGGGGGCTCCCTCC TTCCGGCTGCCGCCTGACCCCTACGTGCCCTGCATCCTCGTGGGCCCTGGCACTGGCATC GCCCCCTTCCGGGGATTTTGGCAGGAGAGGCTGCATGACATTGAGAGCAAAGGGCTGCAG CCCGCCCCCATGACCCTGGTGTTCGGCTGCCGCTGCTCCCAACTCGACCATCTCTACCGC GACGAGGTGCAGGACGCCCAGGAGCGCGGGGTGTTTGGCCGCGTCCTCACCGCCTTCTCC CGGGAACCTGACAGCCCCAAGACCTACGTACAGGACATCCTGAGAACCGAGCTGGCTGCC GAGGTGCACCGCGTGCTGTGCCTCGAGCGGGGCCACATGTTTGTCTGCGGCGATGTCACT ATGGCAACCAGCGTCCTGCAGACGGTGCAGCGCATCTTGGCGACAGAGGGCGACATGGAG CTGGACGAGGCGGGCGACGTCATCGGCGTGCTGCGGGATCAGCAACGCTATCACGAGGAC ATTTTCGGCCTCACGCTGCGCACCCAGGAGGTGACAAGCCGTATACGTACCCAGAGCTTT TCCCTGCAGGAGCGGCATCTGCGGGGCGCGGTGCCCTGGGCCTTCGACCCGCCCGGCCCA GACACCCCCGGCCCCTGA 1205 133287.0 6.92 None >Nitric oxide synthase, endothelial MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSRAPAPATPHAPDHSPAPNSPT LTRPPEGPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRCCLGSLVLPRKLQTRPSPGPP PAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAEVASTGTYHLRESELVFGAKQAW RNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAPGR GDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDE APELFVLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGWYM STEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSFQLAKVTIV DHHAATVSFMKHLDNEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQPD PWKGSATKGAGITRKKTFKEVANAVKISASLMGTLMAKRVKATILYASETGRAQSYAQQL GRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYN SSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYP HFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAKAAFQASCETFCVGEEAKA AAQDIFSPKRSWKRQRYRLSTQAEGLQLLPGLIHVHRRKMFQATVLSVENLQSSKSTRAT ILVRLDTAGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPPPTESVAVEQLEKGSPG GPPPSWVRDPRLPPCTLRQALTFFLDITSPPSPRLLRLLSTLAEEPSEQQELETLSQDPR RYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPNAHPGEVHLTVA VLAYRTQDGLGPLHYGVCSTWLSQLKTGDPVPCFIRGAPSFRLPPDPYVPCILVGPGTGI APFRGFWQERLHDIESKGLQPAPMTLVFGCRCSQLDHLYRDEVQDAQERGVFGRVLTAFS REPDSPKTYVQDILRTELAAEVHRVLCLERGHMFVCGDVTMATSVLQTVQRILATEGDME LDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERHLRGAVPWAFDPPGP DTPGP AAA30667.1 P29473 NOS3_BOVIN 1D0C 1D0O 1D1V 1D1W 1D1X 1D1Y 1DM6 1DM7 1DM8 1DMI 1DMJ 1DMK 1ED4 1ED5 1ED6 1FOI 1FOJ 1FOL 1FOO 1FOP 1I83 1NSE 1P6L 1P6M 1P6N 1Q2O 1RS8 1RS9 1ZZS 1ZZT 2G6O 2HX2 2NSE 3DQS 3DQT 3E7S 3JWW 3JWX 3JWY 3JWZ 3N5P 3N5Q 3N5R 3N5S 3N5T 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLT 3NLU 3NSE 3PNH 3RQO 3RQP 4C3A 4CAR 4CFT 4CTY 4CTZ 4CU0 4CU1 4CUL 4CUM 4CUN 4CVG 4CWV 4CWW 4CWX 4CWY 4CWZ 4CX0 4CX1 4CX2 4D33 4D34 4D35 4D36 4D37 4D38 4D39 4D3A 4IMX 4JSK 4JSL 4JSM 4K5H 4K5I 4K5J 4K5K 4KCP 4KCQ 4KCR 4KCS 4LUW 4NSE 4UH7 4UH8 4UH9 4UHA 4UPQ 4UPR 4UPS 4UPT 5ADJ 5ADK 5ADL 5ADM 5ADN 5FJ2 5FJ3 5FVY 5FVZ 5NSE 5UOD 5VV6 5VV7 5VV8 5VV9 5VVA 5VVG 5VVN 6NSE 7NSE 8NSE 9NSE 1D0C 1DMK 3E7S 4CFT 4NSE 8NSE M99057 NOS3