| Identification |
|---|
| BMDB Protein ID
| BMDBP00044 |
| Secondary Accession Numbers
| None |
| Name
| Prostaglandin G/H synthase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| PTGS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in heme binding |
| Specific Function
| Dual cyclooxygenase and peroxidase in the biosynthesis pathway of prostanoids, a class of C20 oxylipins mainly derived from arachidonate, with a particular role in the inflammatory response. The cyclooxygenase activity oxygenates arachidonate (AA, C20:4(n-6)) to the hydroperoxy endoperoxide prostaglandin G2 (PGG2), and the peroxidase activity reduces PGG2 to the hydroxy endoperoxide PGH2, the precursor of all 2-series prostaglandins and thromboxanes. This complex transformation is initiated by abstraction of hydrogen at carbon 13 (with S-stereochemistry), followed by insertion of molecular O2 to form the endoperoxide bridge between carbon 9 and 11 that defines prostaglandins. The insertion of a second molecule of O2 (bis-oxygenase activity) yields a hydroperoxy group in PGG2 that is then reduced to PGH2 by two electrons. Similarly catalyzes successive cyclooxygenation and peroxidation of dihomo-gamma-linoleate (DGLA, C20:3(n-6)) and eicosapentaenoate (EPA, C20:5(n-3)) to corresponding PGH1 and PGH3, the precursors of 1- and 3-series prostaglandins. In an alternative pathway of prostanoid biosynthesis, converts 2-arachidonoyl lysophopholipids to prostanoid lysophopholipids, which are then hydrolyzed by intracellular phospholipases to release free prostanoids. Metabolizes 2-arachidonoyl glycerol yielding the glyceryl ester of PGH2, a process that can contribute to pain response. Generates lipid mediators from n-3 and n-6 polyunsaturated fatty acids (PUFAs) via a lipoxygenase-type mechanism. Oxygenates PUFAs to hydroperoxy compounds and then reduces them to corresponding alcohols. Plays a role in the generation of resolution phase interaction products (resolvins) during both sterile and infectious inflammation. Metabolizes docosahexaenoate (DHA, C22:6(n-3)) to 17R-HDHA, a precursor of the D-series resolvins (RvDs). As a component of the biosynthetic pathway of E-series resolvins (RvEs), converts eicosapentaenoate (EPA, C20:5(n-3)) primarily to 18S-HEPE that is further metabolized by ALOX5 and LTA4H to generate 18S-RvE1 and 18S-RvE2. In vascular endothelial cells, converts docosapentaenoate (DPA, C22:5(n-3)) to 13R-HDPA, a precursor for 13-series resolvins (RvTs) shown to activate macrophage phagocytosis during bacterial infection. In activated leukocytes, contributes to oxygenation of hydroxyeicosatetraenoates (HETE) to diHETES (5,15-diHETE and 5,11-diHETE) (By similarity). During neuroinflammation, plays a role in neuronal secretion of specialized preresolving mediators (SPMs) 15R-lipoxin A4 that regulates phagocytic microglia (By similarity). |
| Pathways
|
- Lipid metabolism
- Prostaglandin biosynthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| PTGS2 |
| Gene Sequence
|
>1815 bp
ATGCTCGCCCGGGCCCTGCTGCTCTGCGCTGCCGTGGCGCTCAGCGGTGCAGCAAATCCT
TGCTGTTCCCATCCATGTCAGAATCGAGGTGTATGTATGAGTGTAGGATTTGACCAGTAT
AAATGTGACTGTACCCGAACAGGATTCTACGGTGAAAACTGTACCACACCCGAATTTCTG
ACAAGAATAAAATTACTCCTGAAACCCACTCCCAACACAGTGCACTACATACTTACCCAC
TTCAAAGGAGTCTGGAACATTGTCAATAAGATCTCCTTCCTGCGAAATATGATTATGAGA
TATGTGTTGACGTCGAGATCACATTTGATTGAGAGTCCACCAACTTATAATGTGCACTAC
AGCTATAAAAGCTGGGAAGCCTTTTCTAACCTGTCTTATTATACCAGAGCTCTTCCTCCT
GTGCCTGATGACTGCCCAACACCCATGGGTGTGAAAGGGAGGAAAGAGCTTCCTGATTCA
AAAGAAGTTGTGAAAAAAGTACTTCTAAGAAGAAAGTTCATTCCTGATCCCCAGGGCACA
AATCTGATGTTTGCATTCTTTGCCCAGCACTTCACCCATCAATTTTTCAAGACAGATTTT
GAACGAGGACCAGCTTTCACTAAGGGAAAGAACCATGGGGTGGACTTAAGTCACATTTAT
GGTGAATCTTTAGAGAGACAGCATAAGCTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATGATTAATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGTCGAAATGATC
TACCCGCCTCATGTTCCTGAACACTTGAAGTTTGCTGTGGGCCAGGAAGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACCATTTGGCTACGGGAACACAACAGAGTGTGTGAT
GTGCTTAAACAAGAGCATCCAGAATGGGGCGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATCCTGATAGGAGAAACTATTAAGATTGTGATTGAAGACTACGTACAGCACTTGAGTGGC
TATCACTTCAAACTGAAGTTTGACCCAGAGCTGCTTTTCAACCAACAGTTCCAGTACCAG
AACCGTATTGCTGCTGAGTTTAACACGCTCTACCACTGGCATCCCCTTCTGCCTGACGTC
TTTCAGATTGATGGTCAGGAGTACAACTATCAGCAGTTTATCTATAACAACTCTGTCTTA
CTGGAACATGGTCTCACTCAGTTTGTTGAATCATTCACCAGGCAAAGGGCTGGCAGGGTC
GCTGGCGGTAGGAATCTTCCAGTCGCAGTAGAGAAAGTATCAAAGGCTTCAATTGACCAG
AGCAGAGAGATGAAATACCAGTCTTTTAATGAGTATCGCAAACGTTTTCTCGTGAAGCCC
TATGAATCATTTGAGGAACTTACAGGAGAGAAGGAAATGGCTGCAGAGTTAGAAGCGCTC
TATGGAGACATAGATGCCATGGAGTTTTATCCCGCCCTTCTGGTAGAGAAGCCCCGTCCA
GACGCCATCTTTGGGGAGACCATGGTAGAAGCTGGAGCACCATTCTCCCTGAAAGGACTT
ATGGGTAATCCTATATGCTCTCCCGAGTACTGGAAGCCTAGCACTTTCGGTGGAGAAGTA
GGTTTTAAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAGTAACGTGAAAGGC
TGTCCCTTTACCTCATTCAGTGTTCAAGATACGCACCTCACCAAAACGGTCACCATTAAT
GCAAGCTCTTCCCACTCTGGACTAGATGATATCAACCCCACAGTCCTACTAAAGGAACGT
TCAACCGAACTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 604 |
| Molecular Weight
| 69163.0 |
| Theoretical pI
| 7.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Prostaglandin G/H synthase 2
MLARALLLCAAVALSGAANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNKISFLRNMIMRYVLTSRSHLIESPPTYNVHY
SYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGRKELPDSKEVVKKVLLRRKFIPDPQGT
NLMFAFFAQHFTHQFFKTDFERGPAFTKGKNHGVDLSHIYGESLERQHKLRLFKDGKMKY
QMINGEMYPPTVKDTQVEMIYPPHVPEHLKFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDVFQIDGQEYNYQQFIYNNSVLLEHGLTQFVESFTRQRAGRV
AGGRNLPVAVEKVSKASIDQSREMKYQSFNEYRKRFLVKPYESFEELTGEKEMAAELEAL
YGDIDAMEFYPALLVEKPRPDAIFGETMVEAGAPFSLKGLMGNPICSPEYWKPSTFGGEV
GFKIINTASIQSLICSNVKGCPFTSFSVQDTHLTKTVTINASSSHSGLDDINPTVLLKER
STEL
|
| External Links |
|---|
| GenBank ID Protein
| AAC04702.1 |
| UniProtKB/Swiss-Prot ID
| O62698 |
| UniProtKB/Swiss-Prot Entry Name
| PGH2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF031698 |
| GeneCard ID
| PTGS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
