| Identification |
|---|
| BMDB Protein ID
| BMDBP00049 |
| Secondary Accession Numbers
| None |
| Name
| Lactoperoxidase |
| Synonyms
|
Not Available
|
| Gene Name
| LPO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae. |
| Pathways
|
- Thyroid Hormone Synthesis
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19q13 |
| SNPs
| LPO |
| Gene Sequence
|
>2139 bp
ATGTGGGTCTGTCTCCAACTTCCAGTCTTTTTGGCTTCCGTGACCTTATTCGAGGTTGCA
GCATCTGACACAATTGCACAGGCCGCCAGCACCACCACCATCTCTGATGCTGTGAGTAAG
GTCAAGATCCAGGTCAACAAGGCCTTCCTGGATTCCCGGACCAGGCTGAAGACGACCTTG
AGCTCTGAGGCACCCACCACCCAACAGCTCTCAGAGTACTTCAAGCACGCAAAGGGCCGG
ACCCGCACGGCCATTCGCAACGGGCAGGTGTGGGAGGAGTCCTTAAAGAGGCTGAGGCGG
GACACAACCCTGACCAACGTCACAGACCCTAGCCTGGACTTGACTGCACTCTCCTGGGAG
GTGGGCTGCGGTGCCCCGGTTCCTCTGGTGAAATGTGATGAAAACAGCCCTTACCGCACC
ATCACGGGAGACTGTAATAACAGGAGGAGCCCCGCACTGGGCGCCGCCAACAGGGCGCTG
GCGCGCTGGCTGCCGGCGGAGTACGAGGACGGGCTCGCCCTGCCCTTCGGCTGGACGCAG
AGGAAGACGCGCAACGGCTTCCGCGTCCCGCTGGCCCGGGAGGTATCCAACAAAATTGTA
GGCTACCTGGACGAAGAGGGTGTTCTGGACCAAAACAGGTCCCTGCTCTTCATGCAGTGG
GGTCAGATTGTGGACCACGACCTGGACTTCGCCCCGGAAACGGAACTGGGGAGCAACGAG
CACTCTAAAACCCAGTGTGAGGAGTACTGTATCCAGGGAGACAACTGCTTCCCCATCATG
TTCCCGAAAAATGATCCCAAGTTGAAGACTCAAGGGAAATGCATGCCTTTCTTCCGAGCC
GGGTTTGTCTGCCCCACTCCACCTTACCAGTCGTTGGCCCGAGAACAGATCAATGCTGTG
ACCTCCTTCCTGGACGCCAGCTTAGTGTACGGCTCTGAGCCCAGTCTGGCCAGCCGTCTC
CGGAACCTCAGCAGCCCGCTGGGCCTCATGGCTGTCAACCAAGAAGCCTGGGACCACGGG
CTGGCCTACCTGCCCTTTAACAACAAGAAGCCGAGCCCCTGTGAGTTCATCAACACCACC
GCCCGCGTGCCCTGTTTCCTGGCGGGAGATTTTCGAGCCTCAGAGCAGATTCTGCTGGCC
ACTGCCCACACCCTCCTTCTCCGGGAGCACAACCGGCTGGCCAGAGAACTAAAGAAACTC
AACCCTCACTGGAATGGAGAGAAGCTCTACCAGGAAGCCCGGAAAATCCTGGGAGCCTTC
ATACAGATCATCACCTTTAGGGACTACCTACCCATTGTGCTAGGTAGTGAGATGCAGAAG
TGGATCCCGCCCTACCAAGGCTATAATAACTCTGTGGATCCCCGAATTTCCAATGTCTTC
ACCTTTGCCTTCCGCTTTGGCCACATGGAGGTTCCCTCCACTGTGTCCCGCCTGGATGAG
AATTACCAGCCATGGGGTCCGGAAGCAGAGCTCCCCCTACACACCCTCTTCTTCAACACC
TGGAGGATAATCAAAGACGGTGGAATTGACCCTCTGGTGCGGGGTCTGCTGGCCAAGAAG
TCCAAACTGATGAATCAGGATAAAATGGTGACGAGTGAGCTGCGCAACAAGCTTTTCCAG
CCCACTCACAAGATCCACGGCTTTGACCTGGCTGCTATCAACTTACAGCGTTGCCGAGAC
CATGGGATGCCTGGGTACAACTCCTGGAGGGGCTTCTGTGGCCTCTCACAGCCCAAGACA
CTGAAGGGGCTGCAGACTGTGCTGAAGAACAAGATACTGGCTAAGAAGTTAATGGATCTC
TATAAGACCCCCGACAACATTGACATCTGGATTGGAGGCAACGCTGAGCCCATGGTAGAA
AGGGGCCGGGTGGGGCCACTCCTGGCCTGCCTCCTAGGGAGGCAATTCCAGCAGATACGT
GATGGGGACAGGTTCTGGTGGGAGAACCCTGGGGTCTTCACTGAGAAGCAGCGGGACTCT
CTACAGAAAGTGTCCTTCTCACGCCTCATCTGTGACAACACCCACATCACGAAGGTCCCG
CTGCATGCCTTCCAGGCCAACAACTACCCACATGACTTTGTGGATTGCTCAACCGTTGAT
AAGCTGGATCTCTCACCCTGGGCCTCCAGGGAGAATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 712 |
| Molecular Weight
| 80642.0 |
| Theoretical pI
| 8.68 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Lactoperoxidase
MWVCLQLPVFLASVTLFEVAASDTIAQAASTTTISDAVSKVKIQVNKAFLDSRTRLKTTL
SSEAPTTQQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWE
VGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLALPFGWTQ
RKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSNE
HSKTQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLAREQINAV
TSFLDASLVYGSEPSLASRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTT
ARVPCFLAGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKILGAF
IQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFGHMEVPSTVSRLDE
NYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLLAKKSKLMNQDKMVTSELRNKLFQ
PTHKIHGFDLAAINLQRCRDHGMPGYNSWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDL
YKTPDNIDIWIGGNAEPMVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDS
LQKVSFSRLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN
|
| External Links |
|---|
| GenBank ID Protein
| AAA62714.1 |
| UniProtKB/Swiss-Prot ID
| P80025 |
| UniProtKB/Swiss-Prot Entry Name
| PERL_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| M58150 |
| GeneCard ID
| LPO |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
