| Identification |
|---|
| BMDB Protein ID
| BMDBP00105 |
| Secondary Accession Numbers
| None |
| Name
| Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| NMNAT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5. Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following mechanical or toxic insults (By similarity). |
| Pathways
|
- Cofactor biosynthesis
- Deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1
- NAD(+) biosynthesis
- NAD(+) from nicotinamide D-ribonucleotide: step 1/1.
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| Not Available |
| SNPs
| NMNAT1 |
| Gene Sequence
|
>846 bp
ATGGAGAACTCAGAGAAGACAGAAGTAGTTCTCCTTGCTTGTGGGTCCTTTAATCCTATC
ACCAACATGCACCTCCGGCTGTTTGAGCTGGCCAAGGACTACATGAATGGAACAGGAAAA
TATAAAGTTATCAAAGGCATAATTTCTCCAGTTGGTGATGCATATAAGAAGAAAGGACTC
ATCTCTGCCTATCACCGAGTTATCATGGCAGAACTTGCCACCAAGAACTCAAAATGGGTA
GAAGTTGACACATGGGAAAGTCTTCAGAAAGAGTGGACAGAGACAGCCAAGGTGCTAAGA
CACCATCAAGAGAAGCTGGAGGCCAGTATCTGTGATCCCCAGCAGAACTCACCTGTGTTG
GAAAAGCCTGGACGGAAGAGAAAGTGGGCTGAACAAAAACAAGATATTAGTGAAAAGAAA
TCCCTAGAGCAAACAAAAACGAAAGGTGTGCCAAAGGTGAAGCTGCTGTGTGGAGCAGAT
TTTTTGGAGTCCTTTGGTGTGCCCAATCTATGGAAGAGTGAGGATATCACCAAAATCCTG
GGGGACTATGGACTCATATGTATTACTCGGGCTGGAAATGACGCCCAGAAGTTCATCTAC
GAATCCGACGTGCTGTGGAAACACCAGAACAACATTCACCTGGTGAACGAATGGATCACC
AATGACATCTCCTCCACGAAGATCCGGCGAGCCCTCAGACGGGGCCAGAGCATTCGCTAC
TTGGTACCCGATCTTGTCGAAGAATATATTGAAAAGCATAATCTGTATAGCTCTGAGAGT
GAGGAGAGGAATGTTGGAGTGGTCCTGGCTCCTTTGCAGAGAAACACTACAGAAGTTAAG
GCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 281 |
| Molecular Weight
| 32200.0 |
| Theoretical pI
| 9.03 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Nicotinamide mononucleotide adenylyltransferase 1
MENSEKTEVVLLACGSFNPITNMHLRLFELAKDYMNGTGKYKVIKGIISPVGDAYKKKGL
ISAYHRVIMAELATKNSKWVEVDTWESLQKEWTETAKVLRHHQEKLEASICDPQQNSPVL
EKPGRKRKWAEQKQDISEKKSLEQTKTKGVPKVKLLCGADFLESFGVPNLWKSEDITKIL
GDYGLICITRAGNDAQKFIYESDVLWKHQNNIHLVNEWITNDISSTKIRRALRRGQSIRY
LVPDLVEEYIEKHNLYSSESEERNVGVVLAPLQRNTTEVKA
|
| External Links |
|---|
| GenBank ID Protein
| AAI19835.1 |
| UniProtKB/Swiss-Prot ID
| Q0VD50 |
| UniProtKB/Swiss-Prot Entry Name
| NMNA1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC119834 |
| GeneCard ID
| NMNAT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
