| Identification |
|---|
| BMDB Protein ID
| BMDBP00116 |
| Secondary Accession Numbers
| |
| Name
| Dehydrogenase/reductase SDR family member 4 |
| Synonyms
|
Not Available
|
| Gene Name
| DHRS4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| DHRS4 |
| Gene Sequence
|
>783 bp
ATGGCTAGCTGCGGGATGGCGCGCCGGAACCCGCTGGATAATAAAGTGGCCCTAGTAACG
GCCTCCACCGACGGGATCGGTTTTGCCATCGCCCGGCGTCTGGCCCAGGACGGGGCCCAC
GTGGTGGTCAGCAGCCGGAAGCAGCAGAATGTAGACCGGGCAGTGGCAACGCTGAAAGGG
GAGGGGCTGAGCGTCACGGGCACCGTGTGCCACGTAGGGAAGGCTGAGGACCGGGAGCGG
CTGGTGGCCACGGCTGTGAAGCTTCATGGCGGCGTGGACATCCTGATCTCCAATGCTGCC
GTCAGCCCTTTCTTTGGAAGCTTGATGGATGTCCCCGAGGAGGTGTGGGACAAGATTCTG
GACGTTAACGTGAAGGCCACGGCCCTGCTGACAAAGGCAGTGGTGCCAGAGATGGCGAAA
CGAGGAGGCGGCTCGATAGTGATCGTGTCCTCCATAGCAGCCTACAGCCCCTTTCCTAGC
CTGGGTCCTTACAACGTTTCTAAGACAGCCTTGCTGGGCCTCACTAAGAACCTGGCCCTC
GAACTGGCAGAGTCGAATGTTCGGGTGAACTGCCTGGCGCCTGGACTCATCAGGACTAGC
TTCAGCCGTGTGTTGTGGGAGGATCCGGCAAGACAGGAGAGCATAAAAGCTACCTTTCAG
ATCAAAAGGATAGGCAAGCCAGAGGAGTGTGCCGGCATCGTGTCTTTCCTGTGCTCTGAA
GACGCCAGCTACATCACTGGGGAGACAGTGGTGGTAGCTGGAGGGAGCCTATCCCACCTC
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 279 |
| Molecular Weight
| 29440.0 |
| Theoretical pI
| 8.49 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dehydrogenase/reductase SDR family member 4
MASCGMARRNPLDNKVALVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDRAVATLKG
EGLSVTGTVCHVGKAEDRERLVATAVKLHGGVDILISNAAVSPFFGSLMDVPEEVWDKIL
DVNVKATALLTKAVVPEMAKRGGGSIVIVSSIAAYSPFPSLGPYNVSKTALLGLTKNLAL
ELAESNVRVNCLAPGLIRTSFSRVLWEDPARQESIKATFQIKRIGKPEECAGIVSFLCSE
DASYITGETVVVAGGSLSHL
|
| External Links |
|---|
| GenBank ID Protein
| AAI12879.1 |
| UniProtKB/Swiss-Prot ID
| Q8SPU8 |
| UniProtKB/Swiss-Prot Entry Name
| DHRS4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112878 |
| GeneCard ID
| DHRS4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
