| Identification |
|---|
| BMDB Protein ID
| BMDBP00128 |
| Secondary Accession Numbers
| None |
| Name
| Peroxisomal N(1)-acetyl-spermine/spermidine oxidase |
| Synonyms
|
Not Available
|
| Gene Name
| PAOX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in electron carrier activity |
| Specific Function
| Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration. |
| Pathways
|
- Amine and polyamine metabolism
- Spermine metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| PAOX |
| Gene Sequence
|
>1539 bp
ATGCAGTCGGGTGGTCGTCAGGCGGAAGCCCCGGGCCGCGGCCCGCGGGTGCTGGTCGTG
GGCGGCGGCATCGCGGGGCTGGGGGCGGCGCAGAGGCTCTGCCGCCACCCGGCCTTCTCA
CACCTTCGGGTTCTGGAGGCCACGGCCCGCGCCGGTGGCCGCATCCGCTCGGAGCACAGC
TTCGGTGGCGTGGTGGAGGTAGGTGCTCACTGGATCCATGGGCCCTCCCAGGGCAACCCC
GTCTTCCAGCTGGCTGCCAAATACGGGCTGCTTGGGGAGAAGGCCCTGTCCGAGGAGAAC
CAGCTGATCGAGACCGGAGGTCACGTGGGCCTGCCATCTGTGTCTTACGCCAGCTCTGGG
GTAAGTGTGAGCCTTGAGCTCGTGGCGGAGATGGCCAGTCTGTTCTACAGTCTCATAGAC
CAGACCAGGGAGTTCCTGCAGGCGGCTGAGACCACCCCACCCAGTGTCGGGGAGTACCTC
AAGGAGAAGATCCGTCAGCACATGGCTGGCTGGACAGAGGATGAGGAGACCAAGAAGCTC
AAACTGGCCATCCTGAAGAACTTGTTCAACGTGGAGTGCTGTGTGAGCGGTACCCACAGC
ATGGACCTGGTTGCCCTCGCGCCTTTCGGGGAGTACACTGTGCTGCCAGGGCTGGACTGC
ACCTTTCCTGAGGGCTACCAAGGACTCACAGACTGCATCATGGCCTCCTTGCCCAAGGAC
GTGATGGTTTTTGACAAACCCGTGAAGACCATTCACTGGAATGGGTCCTTCCGGGAAGCT
TCTGCTCCTGGGGAGACATTTCCCGTGCTGGTGGAATGTGAGGATGGAGACTGCTTCCCA
GCCCATCACGTGGTCGTCACCGTGCCCTTAGGTTTTTTTAAGAAGCATCTGGACACCTTC
TTTGAGCCACCACTGCCCACTGAAAAGGTGGAAGCGATCAGGAAAATAGGCTTTGGGACG
AACAATAAAATCTTCTTGGAGTTTGAGGAGCCCTTCTGGGAGCCAGACTGCCAGCACATC
CAGGTGGTGTGGGAGGACATGTCGCCCCTGGAGGATACCGCCCCCGAGCTGCAGGATGCC
TGGTTCAAGAAGCTGATTGGCTTCTGGGTCCTGCCTCCCTTCCAGGCCAGCCACGTGCTC
TGTGGCTTTATCGCGGGGCTCGAGTCCGAGTTCATGGAGACACTGTCGGACGAGGACGTG
CTCAGGTCTCTGACGCAGGTGCTCCGCAGGGTGACAGGGAACCCCCAGCTCCCCGCACCC
AGGAGTATGCTGAGGTCCTGCTGGCACAGCGCCCCGTACACCCGGGGCTCATACAGCTAC
GTGGCCGTGGGCAGCTCTGGGGACGACATGGACCGGCTGGCCCAGCCCCTCCCTTCAGAC
GGCAAGGGGGCACAGCTCCAGGTACTGTTCGCAGGGGAAGCCACACACCGGACGTTTTAT
TCCACCACACACGGGGCTCTGCTGTCTGGCTGGAGGGAGGCTGACCGGCTCATGACGCTG
TGGGACCCCCAGGCCCAGTGGCCCGAGCCCAGGCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 512 |
| Molecular Weight
| 56325.0 |
| Theoretical pI
| 5.23 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxisomal N(1)-acetyl-spermine/spermidine oxidase
MQSGGRQAEAPGRGPRVLVVGGGIAGLGAAQRLCRHPAFSHLRVLEATARAGGRIRSEHS
FGGVVEVGAHWIHGPSQGNPVFQLAAKYGLLGEKALSEENQLIETGGHVGLPSVSYASSG
VSVSLELVAEMASLFYSLIDQTREFLQAAETTPPSVGEYLKEKIRQHMAGWTEDEETKKL
KLAILKNLFNVECCVSGTHSMDLVALAPFGEYTVLPGLDCTFPEGYQGLTDCIMASLPKD
VMVFDKPVKTIHWNGSFREASAPGETFPVLVECEDGDCFPAHHVVVTVPLGFFKKHLDTF
FEPPLPTEKVEAIRKIGFGTNNKIFLEFEEPFWEPDCQHIQVVWEDMSPLEDTAPELQDA
WFKKLIGFWVLPPFQASHVLCGFIAGLESEFMETLSDEDVLRSLTQVLRRVTGNPQLPAP
RSMLRSCWHSAPYTRGSYSYVAVGSSGDDMDRLAQPLPSDGKGAQLQVLFAGEATHRTFY
STTHGALLSGWREADRLMTLWDPQAQWPEPRL
|
| External Links |
|---|
| GenBank ID Protein
| AAY83881.1 |
| UniProtKB/Swiss-Prot ID
| Q865R1 |
| UniProtKB/Swiss-Prot Entry Name
| PAOX_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| DQ058607 |
| GeneCard ID
| PAOX |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
