| Identification |
|---|
| BMDB Protein ID
| BMDBP00129 |
| Secondary Accession Numbers
| None |
| Name
| Acid ceramidase |
| Synonyms
|
Not Available
|
| Gene Name
| ASAH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ceramidase activity |
| Specific Function
| Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Has also an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| ASAH1 |
| Gene Sequence
|
>1188 bp
ATGTTAGGCTGGAGTCGTCTAACCTTCATCTTGCTGAGCGGGATCGTCACCTGCTTGGTG
GCGCAGCAGGTGCCACCGTGGACTGAAGACTGCAGAAAATCAACCTATCCTCCTTCAGGG
CCCACTTACAGGGGTCCAGTTCCATGGTACACCATAAATCTCGATTTACCACCGTACAAA
AGATGGCATGAATTGATGGTGGTCAAAGCACCAGCGCTGAAAGTTATAGTGAATTCCATG
AAGAATATAGTAAATGCATTTGTGCCAAGTGGAAAAATTATACACTTAGTGGATCAAAAG
TTGCCTGGTCTGCTTGGCAACTTCCCTGGCCCTTTCGAGGAGGAAATGAAGGGGATTGCA
GCTGTAACTGAAATCCCTTTAGGAGAGATTATTTTATTCAATATTTTCTATGAATTTTTT
ACCATTTGTACTTCAATAATAACAGAAGACAAAGAAGGTCATCTACTACATGGGCGAAAC
TTGGATTTTGGAGTATTTCTTGGGTGGAATATAAATAATGATACTTGGGTCATAACTGAG
GAACTAAAACCTTTAACAGTGAATTTGGACTTCCAGAGGAACAATAAAACTCTCTTCAAG
GCAACAACCTTTGCTGGCTACGTGGGCATGTTAACAGGATTCAAACCAGGACTGTTTAGT
GTTACGCTCAATGAACGCTTCAGTATAGATGGTGGTTTTATGGGTGTCATGGAATGGATT
TTGGGAAAGAAAGATGCCCAGTGGGTAGGGTTTATCATTAGATCAGTTCTAGAAAATAGC
ACAAGTTATGAAGAAACCAAGAATATATTGACCAAAACCAAGATATTGGCCCCAGCATAC
TTTATCCTGGGAGGCAACCAGTCTGGGGAGGGTTGTGTGATTACACGAGACAGAAAACAG
TCTCTGGATATATATGAACTCGACCCCAAGCACGGTAGATGGTATGTGGTACAAACAAAT
TATGACCGATGGAAAAATCCCTTCTTCCTTGATGATCGCAGAACACCTGCGAAGATGTGT
CTGAACCAGACAACCCAAGAGAATATCTCATTTGCAACCATATATGATGTCTTGTCAACA
AAACCTATCCTCAACAAGCTGACGGTGTACACAGTCTTGATAGATGTTACCAAAGGTCAA
TTTGAGACGTACCTGCGGGACTGCCCAGACCCCTGCATAGGGTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 395 |
| Molecular Weight
| 44965.0 |
| Theoretical pI
| 7.38 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acid ceramidase
MLGWSRLTFILLSGIVTCLVAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYK
RWHELMVVKAPALKVIVNSMKNIVNAFVPSGKIIHLVDQKLPGLLGNFPGPFEEEMKGIA
AVTEIPLGEIILFNIFYEFFTICTSIITEDKEGHLLHGRNLDFGVFLGWNINNDTWVITE
ELKPLTVNLDFQRNNKTLFKATTFAGYVGMLTGFKPGLFSVTLNERFSIDGGFMGVMEWI
LGKKDAQWVGFIIRSVLENSTSYEETKNILTKTKILAPAYFILGGNQSGEGCVITRDRKQ
SLDIYELDPKHGRWYVVQTNYDRWKNPFFLDDRRTPAKMCLNQTTQENISFATIYDVLST
KPILNKLTVYTVLIDVTKGQFETYLRDCPDPCIGW
|
| External Links |
|---|
| GenBank ID Protein
| AAI18456.3 |
| UniProtKB/Swiss-Prot ID
| Q17QB3 |
| UniProtKB/Swiss-Prot Entry Name
| ASAH1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118455 |
| GeneCard ID
| ASAH1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
