1.0 2018-05-07 22:21:02 UTC 2020-05-20 21:01:26 UTC BMDBP00147 Enzyme GET3 Inorganic ion transport and metabolism ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting. BMDB0001341 ADP BMDB0001429 Phosphate BMDB0002290 Arsenic BMDB0011620 Arsenite 7 >1047 bp ATGGCGGCAGGGGTGGCCGGGTGGGGGGTTGAGGCAGAGGAGTTCGAGGATGCCCCTGAT GTGGAGCCGCTGGAGCCCACGCTTAGCAACATCATCGAGCAGCGCAGCCTTAAGTGGATC TTCGTTGGGGGCAAAGGTGGAGTTGGCAAAACAACCTGCAGCTGCAGCCTAGCAGTCCAG CTGTCCAAGGGGCGGGAGAGTGTTCTGATCATCTCCACCGACCCAGCCCACAACATCTCC GATGCATTTGACCAGAAGTTCTCCAAGGTGCCTACCAAGGTCAAAGGCTATGACAACCTC TTTGCCATGGAGATTGACCCCAGCCTGGGCGTGGCGGAGCTGCCAGACGAGTTCTTTGAA GAGGACAACATGCTGAGCATGGGCAAAAAGATGATGCAAGAAGCTATGAGCGCATTCCCA GGCATCGACGAGGCCATGAGCTACGCAGAGGTGATGAGGCTGGTGAAGGGCATGAACTTC TCCGTGGTGGTGTTCGACACTGCGCCCACAGGCCACACGCTGAGGCTGCTCAACTTCCCC ACCATCGTCGAGCGGGGGCTTGGCCGCCTCATGCAGATCAAGAACCAGATCAGCCCCTTC ATCTCACAGATGTGCAACATGCTGGGCCTCGGCGACATGAACGCAGACCAGCTGGCCTCC AAGCTAGAGGAGACGCTGCCTGTCATCCGCTCGGTCAGCGAGCAGTTCAAGGACCCTGAG CAAACAACCTTCATCTGTGTGTGCATCGCGGAGTTCCTGTCCCTGTATGAAACCGAACGG CTGATCCAGGAGCTGGCCAAGTGCAAGATTGACACGCACAACATCATCGTCAACCAGCTC GTCTTCCCTGATCCCGAGAAGCCCTGCAAGATGTGTGAGGCCCGCCACAAGATCCAAGCC AAGTACCTGGATCAGATGGAGGACCTATATGAAGACTTCCACATTGTGAAGCTGCCGCTG CTGCCCCATGAGGTTCGGGGAGCAGACAAGGTCAACACCTTCTCCGCTCTCCTCCTGGAG CCCTACAAGCCCCCCAGCGCGCAGTAG 348 38793.0 4.54 None >Arsenical pump-driving ATPase MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQ LSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFE EDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFP TIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPE QTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQA KYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSAQ AAI42126.1 A5PJI5 GET3_BOVIN BC142125 GET3