| Identification |
|---|
| BMDB Protein ID
| BMDBP00156 |
| Secondary Accession Numbers
| None |
| Name
| Ectonucleoside triphosphate diphosphohydrolase 8 |
| Synonyms
|
Not Available
|
| Gene Name
| ENTPD8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity). |
| Pathways
|
|
| Reactions
|
| IDP + Water → Inosinic acid + Hydrogen phosphate |
details
|
| Inosine triphosphate + Water → IDP + Hydrogen phosphate |
details
|
| Guanosine triphosphate + Water → Guanosine diphosphate + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ENTPD8 |
| Gene Sequence
|
>1488 bp
ATGGGGCTGACCTGGAAGCAGCGGGTCTTCACGGCTCTGCTGGGCGCAGCAGCGGTCTCA
GGCCTCACCGCGCTGCTTCTCGTCCTGGTGGGGACCATGAACGTCCTCCTGCCTCCAGAC
ACCAAGTTTGGGATCGTGTTCGACGCTGGGTCCTCCCACACATCCCTCTTTGTGTATCAG
TGGCCGGCCAACAAGGAGAACGACACCGGCATAGTCAGCCAGGCCCTGGCCTGCCAGGCG
GAAGGGCCTGGAATCTCGTCTTACGCCTCCAACCCTGCGCGGGTTGGCGAGAGCCTGCAG
GGCTGCCTGGAGGAGGCGCTAGCACTGATCCCAAAGGCCAAGCATCATGAGACACCCATG
TTCCTGGGGGCCACTGCAGGCATGCGGCTGCTCAGCCGCAAGAATCGCTCCCAGGCGGAG
GACGTGTTCGCCGCGGTCAGCCGGGCCCTGGGCCAGTCACCGGTGGACTTCCGGGGCGCA
GAGCTCCTGACGGGGCAGGACGAAGGCGCCTTTGGTTGGATCACCATCAACTACATCCTT
GGCCTGCTGGTGAAGTACTCCTTCTCTGGAGAGTGGATCCGGCCCCTGGAGGAGACGCTG
GTGGGCGCCCTGGACATGGGTGGGGCCTCCACCCAGATTACCTTTGTACCTGGAGGCCCC
ATCCTGGACAAGACCGCCCAGGCCACCTTCCGCCTCTACGGTGCCGACCACACCGTCTAC
ACCCACAGCTACCTCTGCTTCGGGCGCGACCAGGCGCTGAGCAGGGTGCTGGCCGAGCTG
GTGCAGGCCAGCACGGGCCTCCTGATCCGCCACCCCTGCTACCACAGCGGCTACCGGGGC
ACGCTGGCCCTGGCGTCCCTGTATGAGTCGCCCTGCGCCCCGGCAGCGCCCCCCGACCTC
AGCCAGAACCTCACCGTGGAGGGCACGGGGAACCCCGGGGCCTGCGTCGAGGCCCTCCGG
AAGCTCTTCAATTTCTCCAGCTGTGACGGCCGAGAAGACTGTGCCTTCGCCGGGGTCTAC
CAGCCCCCCGTGCAGGGCCAGTTCTACGCTTTCTCCAACTTCTACTACACCTTCAACTTC
CTGAACCTCACCTCCAAGCCGTCACTGAGTGGGGCCAACGCCACCATCTGGGAGTTCTGC
CTGCGGCCCTGGAAGCTGGTGGAGGCGAGCGCGCCCCCGGGCCAGGACCGCTGGCTGCGG
GACTACTGTGCCTCGGGCCTATACATCCTCACGCTCCTGGTCGAGGGCTACGGGTTCAGT
GAGGAGACCTGGGGAGGCATCGAGTTCCGCCAGCAGGCCGGCGGCGCTGACATCGGCTGG
ACGCTGGGCTACATGCTGAACCTGACCAACCTGATCCCGGCCGAGGCGCCCGCCCAGGGT
TGGGCACAGAGCTTCGGCGTCTGGGCGGCCGGGGTCGTCTTCGTGGTGCTGACGCTCGCG
GCCACCCTGGGTGCCGTGGCAGTGCAGGTCTTCTGGCTCCAGGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 495 |
| Molecular Weight
| 53240.0 |
| Theoretical pI
| 4.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ectonucleoside triphosphate diphosphohydrolase 8
MGLTWKQRVFTALLGAAAVSGLTALLLVLVGTMNVLLPPDTKFGIVFDAGSSHTSLFVYQ
WPANKENDTGIVSQALACQAEGPGISSYASNPARVGESLQGCLEEALALIPKAKHHETPM
FLGATAGMRLLSRKNRSQAEDVFAAVSRALGQSPVDFRGAELLTGQDEGAFGWITINYIL
GLLVKYSFSGEWIRPLEETLVGALDMGGASTQITFVPGGPILDKTAQATFRLYGADHTVY
THSYLCFGRDQALSRVLAELVQASTGLLIRHPCYHSGYRGTLALASLYESPCAPAAPPDL
SQNLTVEGTGNPGACVEALRKLFNFSSCDGREDCAFAGVYQPPVQGQFYAFSNFYYTFNF
LNLTSKPSLSGANATIWEFCLRPWKLVEASAPPGQDRWLRDYCASGLYILTLLVEGYGFS
EETWGGIEFRQQAGGADIGWTLGYMLNLTNLIPAEAPAQGWAQSFGVWAAGVVFVVLTLA
ATLGAVAVQVFWLQD
|
| External Links |
|---|
| GenBank ID Protein
| AAI26638.1 |
| UniProtKB/Swiss-Prot ID
| A0JND9 |
| UniProtKB/Swiss-Prot Entry Name
| ENTP8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126637 |
| GeneCard ID
| ENTPD8 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
