| Identification |
|---|
| BMDB Protein ID
| BMDBP00177 |
| Secondary Accession Numbers
| None |
| Name
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
| Synonyms
|
Not Available
|
| Gene Name
| ENPP2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in alkylglycerophosphoethanolamine phosphodies |
| Specific Function
| Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine (PubMed:12119361). Also can act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor (By similarity). Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids (By similarity). Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| ENPP2 |
| Gene Sequence
|
>2667 bp
ATGGCCAGGAGACGCTCCTGCCAGCTCCATCAGGTGATATCTCTGTTCACTTTTGCCGTC
GGTGTCAATATCTGCTTAGGAGTCACAGCAAATCGAATTAAGAGGGCAGAAGGATGGGGT
GAAGGCCCTCCTACAGTGTTATCAGACTCCCCCTCGATCAACATCTCTGGGTCTTGCAAG
GGCAGATGCTTTGAACTTCAAGAGGCTGGACCCCCTGATTGTCGATGTGACAACTTGTGT
AAGAGCTATAGCAGCTGCTGCCTTGACTTTGATGAGCTCTGCTTGAAGACAGCTGGTGGC
TGGGAGTGTACCAAGGACAGATGCGGAGAAGTAAGAAATGAAGACCATGCTTGTCACTGC
TCGGAGGACTGCTTGGCCCGGGGAGACTGTTGCACTAATTACCAAGTGGTTTGCAAAGGA
GAGTCTCACTGGGTGGATGATGACTGTGAGGAAATAAAGACCCCAGAATGCCCTGCAGGG
TTCGTTCGCCCTCCGCTGATCATCTTCTCTGTGGACGGTTTCCGCGCATCGTACATGAAG
AAAGGCAGCAAGGTCATGCCTAACATCGAAAAGCTGAGGTCTTGTGGCACTCACTCCCCC
TACATGAGGCCTGTGTACCCGACGAAAACTTTCCCTAACTTATACACTCTGGCCACTGGG
CTGTATCCAGAATCACATGGAATTGTTGGCAATTCCATGTATGATCCTGTTTTTGATGCA
CATTTCAACCTTCGAGGGCGAGAGAAATTTAACCATAGGTGGTGGGGAGGTCAACCGCTA
TGGATTACAGCCACGAAGCAAGGGGTGATCGCTGGGACATTCTTCTGGCCTGTGGTGATC
CCCCACGAGCGGAGAATACTGACCATCCTGCAGTGGCTGACCCTGCCGGACCACGAAAGG
CCTTCAGTCTATGCCTTCTATTCCGAACAACCTGATTTCTCTGGACACAAGTATGGCCCC
TTTGGCCCTGAGATGACGAATCCTCTGAGGGACATTGACAAAACCGTGGGGCAGTTAATG
GATGGATTGAAGCAACTGAAGCTGCACCGCTGCGTGAATGTCATCTTCGTTGGAGACCAT
GGAATGGAAGATGTCACATGTGATAGAACAGAATTCTTGAGCAATTACCTGACTAATGTG
GATGATATTATTTTAGTGCCAGGAACTCTAGGAAGAATTCGACCCAAATTCAACAATCAT
GCTAAATATGACCCGAAAGTCATTATTGCTAATCTCACGTGTAAAAAACCAGACCAGCAC
TTTAAGCCTTACTTGAAACAGCACCTTCCCAAACGTTTGCACTACGCCAACAACAGAAGG
ATCGAAGACGTCCATTTACTGGTGGAGCGCAGATGGCACGTCGCAAGGAAACCTTTGGAG
GTTTATAAGAAACCATCAGGAAAATGTTTTTTCCAGGGAGACCACGGATTTGATAACAAG
GTCAACAGTATGCAGACTGTTTTTGTAGGTTATGGCCCAACATTTAAGTACAAGACCAAA
GTGCCTCCATTTGAAAACATTGAACTTTACAACGTTATGTGCGATCTCCTGGGATTGAAG
CCAGCTCCAAATAACGGGACCCACGGGAGTCTGAACCATCTCCTGCGTACCAACACCTTC
AGACCGACTGTGCCAGAGGAAGTCACCAGACCCAATTACCCAGGGGTTATGTACCTTCAG
TCCGATTTTGACCTGGGCTGTACCTGTGATGATAAGGCAGAGCCAAAGAACAAATTGGAT
GAACTCAACAAACACCTTCATATAAAAGAGTCCACAGAAGCTGAAACCAGGAAATTCAGA
GGCAGCAAAAATGAAATCAAGGAAAACGTTAATGGAAATTTTGAACCTAGAAAAGAGAGA
CATCTCCTCTATGGACGGCCTGCCGTGCTCTATCGGACTAGATATGATATCTTATATCAC
ACTGACTTTGAAAGCGGTTATAGTGAAATATTTCTAATGCCACTCTGGACATCATACACT
GTTTCCAAACAGGCTGACGTCTCTGACATCCCTGCACACCTGACCAACTGTGTCCGGCCC
GACGTCCGCGTTTCTCCGAGTTTCAGTCAGAGCTGTTTGGCCTACAAAAATGATAAACAG
ATGTCCTATGGATTCCTCTTTCCTCCCTATCTGAGCTCGTCCCCAGAAGCTAAATATGAT
GCATTCCTTGTAACCAATATGGTTCCAATGTATCCTGCTTTTAAACGCATCTGGAATTAT
TTCCAAAGGGTTCTGGTGAAGAAATATGCTTCAGAAAGAAATGGAGTTAATGTGATAAGT
GGACCAATCTTTGACTATGACTACGATGGCTTACACGACACACAAGACAAAATCAAACAG
TACGTGGAGGGCAGCTCCGTCCCCGTGCCCACCCACTACTACAGCATCCTCACCAGCTGC
CTGGACTTCACGCAGCCTGCCGACCGCTGCGACGGGCCGCTCTCCGTGTCCGCCTTCGTG
CTGCCCCACAGGCCCGACAACGACGAGAGCTGCAACAGCTCAGAGGACGAGTCGAAATGG
GTGGAAGAGCTTCTCAAGATGCACACAGCACGGGTGCGGGACATCGAGCATCTCACCAGC
CTGGACTTCTTCCGCAAGACCAGCCGCAGCTACCCAGAAATTCTGACCCTAAAGACGTAC
CTGCAGACGTATGAGAGCGAGATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 888 |
| Molecular Weight
| 101717.0 |
| Theoretical pI
| 7.56 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
MARRRSCQLHQVISLFTFAVGVNICLGVTANRIKRAEGWGEGPPTVLSDSPSINISGSCK
GRCFELQEAGPPDCRCDNLCKSYSSCCLDFDELCLKTAGGWECTKDRCGEVRNEDHACHC
SEDCLARGDCCTNYQVVCKGESHWVDDDCEEIKTPECPAGFVRPPLIIFSVDGFRASYMK
KGSKVMPNIEKLRSCGTHSPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDA
HFNLRGREKFNHRWWGGQPLWITATKQGVIAGTFFWPVVIPHERRILTILQWLTLPDHER
PSVYAFYSEQPDFSGHKYGPFGPEMTNPLRDIDKTVGQLMDGLKQLKLHRCVNVIFVGDH
GMEDVTCDRTEFLSNYLTNVDDIILVPGTLGRIRPKFNNHAKYDPKVIIANLTCKKPDQH
FKPYLKQHLPKRLHYANNRRIEDVHLLVERRWHVARKPLEVYKKPSGKCFFQGDHGFDNK
VNSMQTVFVGYGPTFKYKTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTF
RPTVPEEVTRPNYPGVMYLQSDFDLGCTCDDKAEPKNKLDELNKHLHIKESTEAETRKFR
GSKNEIKENVNGNFEPRKERHLLYGRPAVLYRTRYDILYHTDFESGYSEIFLMPLWTSYT
VSKQADVSDIPAHLTNCVRPDVRVSPSFSQSCLAYKNDKQMSYGFLFPPYLSSSPEAKYD
AFLVTNMVPMYPAFKRIWNYFQRVLVKKYASERNGVNVISGPIFDYDYDGLHDTQDKIKQ
YVEGSSVPVPTHYYSILTSCLDFTQPADRCDGPLSVSAFVLPHRPDNDESCNSSEDESKW
VEELLKMHTARVRDIEHLTSLDFFRKTSRSYPEILTLKTYLQTYESEI
|
| External Links |
|---|
| GenBank ID Protein
| AAI26632.1 |
| UniProtKB/Swiss-Prot ID
| A1A4K5 |
| UniProtKB/Swiss-Prot Entry Name
| ENPP2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC126631 |
| GeneCard ID
| ENPP2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
