| Identification |
|---|
| BMDB Protein ID
| BMDBP00186 |
| Secondary Accession Numbers
| None |
| Name
| Integrin-linked protein kinase |
| Synonyms
|
Not Available
|
| Gene Name
| ILK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| ILK |
| Gene Sequence
|
>1359 bp
ATGGACGACATTTTCACTCAGTGCCGGGAGGGCAACGCGGTTGCGGTCCGCCTGTGGCTG
GACAACACGGAGAACGACCTCAACCAGGGGGACGATCATGGCTTCTCCCCCTTGCACTGG
GCCTGCCGAGAAGGCCGATCTGCTGTGGTTGAGATGCTGATCATGCGGGGGGCACGAATC
AATGTGATGAACCGTGGGGATGATACCCCTCTGCACCTGGCAGCCAGTCATGGGCACCGT
GATATTGTACAGAAGCTGCTGCAGTACAAAGCTGACATCAATGCGGTGAATGAGCATGGG
AATGTGCCCCTGCACTATGCCTGTTTCTGGGGCCAAGATCAGGTGGCAGAGGACCTCGTG
GCAAATGGGGCCCTTGTCAGCATCTGTAACAAGTATGGAGAGATGCCTGTGGACAAAGCT
AAGCCACCCCTGAGAGAGCTGCTCCGAGAGCGGGCAGAGAAGATGGGCCAGAATCTGAAC
CGTATACCATACAAGGACACATTCTGGAAGGGGACTACCCGCACTCGGCCCCGAAATGGG
ACTCTGAACAAACACTCCGGCATTGACTTCAAACAGCTCAACTTCCTGGCGAAGCTCAAC
GAGAATCACTCTGGAGAGCTATGGAAGGGCCGCTGGCAGGGCAATGACATTGTCGTGAAG
ATGCTAAAGGTTCGAGACTGGAGTACAAGGAAGAGCAGAGACTTCAATGAGGAGTGTCCC
CGGCTCAGGATTTTCTCACATCCCAATGTGCTCCCAGTGCTTGGTGCCTGTCAGTCTCCA
CCTGCTCCTCACCCCACCCTCATCACACACTGGATGCCATACGGATCCCTGTACAATGTG
CTACATGAAGGCACCAATTTTGTTGTGGACCAGAGCCAGGCTGTGAAGTTTGCATTGGAC
ATGGCAAGGGGCATGGCCTTCCTACACACACTAGAGCCCCTCATCCCACGACATGCACTC
AACAGCCGTAGTGTAATGATTGATGAGGACATGACTGCTCGAATCAGTATGGCCGACGTC
AAGTTCTCCTTCCAGTGCCCCGGGCGCATGTATGCACCTGCCTGGGTGGCTCCTGAAGCT
CTGCAAAAGAAGCCTGAAGACACAAACAGACGCTCAGCAGATATGTGGAGTTTTGCAGTG
CTTCTATGGGAACTGGTGACACGGGAGGTACCCTTTGCTGACCTCTCCAACATGGAAATT
GGAATGAAGGTGGCACTGGAAGGCCTTCGGCCTACCATCCCACCAGGCATTTCCCCCCAC
GTATGTAAACTCATGAAGATCTGCATGAATGAAGACCCTGCTAAGCGACCCAAGTTTGAC
ATGATCGTGCCTATCCTGGAGAAGATGCAGGACAAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 452 |
| Molecular Weight
| 51447.0 |
| Theoretical pI
| 8.18 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Integrin-linked protein kinase
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI
NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV
ANGALVSICNKYGEMPVDKAKPPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG
TLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKMLKVRDWSTRKSRDFNEECP
RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD
MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA
LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH
VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
|
| External Links |
|---|
| GenBank ID Protein
| AAI04604.1 |
| UniProtKB/Swiss-Prot ID
| Q3SWY2 |
| UniProtKB/Swiss-Prot Entry Name
| ILK_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC104603 |
| GeneCard ID
| ILK |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
