| Identification |
|---|
| BMDB Protein ID
| BMDBP00244 |
| Secondary Accession Numbers
| None |
| Name
| Peroxisomal carnitine O-octanoyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| CROT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in carnitine O-octanoyltransferase activity |
| Specific Function
| Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. |
| Pathways
|
- Beta Oxidation of Very Long Chain Fatty Acids
- Fatty acid beta-oxidation
- Lipid metabolism
- Oxidation of Branched-Chain Fatty Acids
- Phospholipid Biosynthesis
|
| Reactions
|
| Choline → Acetylcholine |
details
|
| Acetyl-CoA + L-Carnitine → L-Acetylcarnitine + Coenzyme A |
details
|
| Lauroyl-CoA → Coenzyme A + Dodecanoic acid |
details
|
| L-Acetylcarnitine + L-Carnitine → Acetyl-CoA + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| CROT |
| Gene Sequence
|
>1839 bp
ATGGAAAATCAACTGGCTAAATCAACTGAAGAAAGGACATTTCAGTACCAAGATTCCCTT
CCATCGCTGCCTGTTCCTTCACTTGAAGAATCATTAAAAAAATACCTTGAATCAGTAAAG
CCATTTGCAAATGAGGAAGAATATAAGAATACTGAAGCAATTGTCTGGAAATTTCAAAAT
GGCATTGGAGAAAAATTGCAGCAGAAATTACTTCAAAGAGCAAAAGGAAGAAGAAACTGG
CTGGAAGAGTGGTGGCTGAATGTTGCCTACCTGGATGTTCGTATACCATCACAACTGAAT
GTCAACTTTGGGGGTCCTGCAAGCCATATTGAACACTACTGGCCTCCAAAGGAAGGCACA
CAGTTGGAAAGAGGAAGTATAAGTCTTTGGCATAACTTGAACTACTGGCAGCTATTAAGA
AAAGAAAAGTTAGCTGTTGAAAAAGTTGGAAATACTCCTCTAGATATGAATCAATTCCGA
ATGCTGTTTTCCACCTGCAAGATTCCAGGAATTACTAGAGATTCAATTATTAATTATTTT
AGGACTGAGAGTGAAGGACATTCTCCAAGTCACCTTGCAGTGTTGTGTCGAGGCCGAGTT
TTTGTCTTTGATGTAATGCATGAGGGATATCTGATGACTGCACCAGAGATTCAGAGGCAA
TTGACATACATCCAAAAGAAATGCCACAGTGAACCCGACGGACCTGGGGTAGCAGCGTTA
ACTACTGAGGAGCGAACTCGATGGGCTAAGGCACGAGAATATTTGATTAGTCTTAATCCA
GAGAACCTGACTATATTAGAAAAAATTCAGAGCAGTTTACTGGTATTTTGTTTAGATGAT
GACAGTCCACATGTTACACCAGAAGATTATTCTCAGGTTTCTGCAAAGATTCTTAATGGA
GACCCAACAGTACGCTGGGGTGACAAATCTTATAACTTGATTGCCTTTTCTAATGGAGTA
TTTGGCAGTAATTGTGATCATGCTCCTTTTGATGCAATGGTTCTGGTAAAAGTCTGCTAT
TATGTTGATGAGAACATTCTTGAGAATGAAGGAAGATGGAAGGGCTCAGAAAAAGTACGG
GATATACCGGTTCCAGAGGAGCTTGTTTTCACTGTGGATGAAAAAGTATTAAATGACATC
AACCAAGCTAAGGCCCAGTATTTCAAGCAGGTGTCCGATCTCCAGCTTGTGGTATATGCC
TTTACGTCTTTTGGCAAAAAGCTAACCAAGGAGAAGCAGCTTCACCCTGATACATTTATT
CAGCTGGCACTTCAGTTGGCCTATTACAGACTTCATGGACGTCCTGGTTGCTGCTATGAA
ACAGCTATGACAAGATTATTTTATCATGGCCGTACAGAGACTGTGCGACCATGTACAGTA
GAAGCAGTCAATTGGTGCCAATCCATGCAGAATCCTTCTACCAGTCTTCTTGAGCGGAAG
CACATGATGTTAGAAGCTTTTGCAAAACATAATAAAATGATGAAAGATTGTTCAACTGGA
AAAGGATTTGACCGTCATCTCTTAGGCCTCTCACTCATAGCAAAGGAGGAAGGCCTCCCT
GTTCCAGAACTCTTCACAGACCCCCTCTTCTCCAGGAGTGGAGGAGGTGGAAACTTTGTT
CTCTCAACCAGTCTGGTTGGTTATTTAAGAGTCCAGGGCGTGATGGTTCCCATGGTGCAC
AATGGCTATGGATTCTTCTATCATATCAGAGATGACAGGTTTGTTGTGTCCTGTTCAGCC
TGGAAATCATGTCCAGAGACTGATGCAGAGAAGCTAGTTCAGCAGGTTTTTCATGCTTTC
TGTGATATGATGCAACTGATGGAAATGCCTCATCTCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 612 |
| Molecular Weight
| 70263.0 |
| Theoretical pI
| 6.72 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Peroxisomal carnitine O-octanoyltransferase
MENQLAKSTEERTFQYQDSLPSLPVPSLEESLKKYLESVKPFANEEEYKNTEAIVWKFQN
GIGEKLQQKLLQRAKGRRNWLEEWWLNVAYLDVRIPSQLNVNFGGPASHIEHYWPPKEGT
QLERGSISLWHNLNYWQLLRKEKLAVEKVGNTPLDMNQFRMLFSTCKIPGITRDSIINYF
RTESEGHSPSHLAVLCRGRVFVFDVMHEGYLMTAPEIQRQLTYIQKKCHSEPDGPGVAAL
TTEERTRWAKAREYLISLNPENLTILEKIQSSLLVFCLDDDSPHVTPEDYSQVSAKILNG
DPTVRWGDKSYNLIAFSNGVFGSNCDHAPFDAMVLVKVCYYVDENILENEGRWKGSEKVR
DIPVPEELVFTVDEKVLNDINQAKAQYFKQVSDLQLVVYAFTSFGKKLTKEKQLHPDTFI
QLALQLAYYRLHGRPGCCYETAMTRLFYHGRTETVRPCTVEAVNWCQSMQNPSTSLLERK
HMMLEAFAKHNKMMKDCSTGKGFDRHLLGLSLIAKEEGLPVPELFTDPLFSRSGGGGNFV
LSTSLVGYLRVQGVMVPMVHNGYGFFYHIRDDRFVVSCSAWKSCPETDAEKLVQQVFHAF
CDMMQLMEMPHL
|
| External Links |
|---|
| GenBank ID Protein
| AAC48758.1 |
| UniProtKB/Swiss-Prot ID
| O19094 |
| UniProtKB/Swiss-Prot Entry Name
| OCTC_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U65745 |
| GeneCard ID
| CROT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
