| Identification |
|---|
| BMDB Protein ID
| BMDBP00361 |
| Secondary Accession Numbers
| None |
| Name
| Elongator complex protein 3 |
| Synonyms
|
Not Available
|
| Gene Name
| ELP3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Transcription |
| Specific Function
| Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (By similarity). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| ELP3 |
| Gene Sequence
|
>1644 bp
ATGAGGCAGAAGCGCAAAGGCGACCTCAGCCCTGCTCAGCTAATGATGCTGACCATAGGA
GATGTTATTAAACAACTAATTGAAGCTCACGAACAGGGGAAAGACATCGATCTAAATAAG
GTGAAGACCAGGACAGCTGCCAAATACGGGCTCTCGGCACAGCCCCGCCTGGTGGACATC
ATCGCCGCGGTCCCGCCTCAGTATCGGAAGGTCTTGGTCCCCAAGCTGAAGGCGAAACCC
ATCAGAACCGCCAGTGGGATTGCTGTTGTGGCTGTCATGTGCAAACCCCACAGATGTCCA
CACATCAGTTTTACAGGAAATATATGTGTGTACTGCCCTGGCGGACCTGATTCAGATTTC
GAATATTCCACCCAGTCTTACACTGGATATGAGCCAACCTCCATGCGAGCTATCCGTGCC
AGGTATGACCCTTACCTGCAGACAAGACACCGGATCGAACAGTTAAAACAGCTTGGTCAC
AGTGTGGATAAAGTGGAATTTATCGTGATGGGTGGAACATTTATGGCCCTTCCAGAAGAA
TACAGAGATTATTTTATTCGAAATTTACATGATGCCTTATCAGGACATACCTCCAACAAT
ATTTATGAGGCCGTCAAGTATTCTGAGAGAAGCCTCACAAAGTGCATCGGAATTACTATT
GAGACCAGACCAGATTACTGCATGAAGCGGCATCTCAGTGACATGTTGACCTATGGCTGC
ACAAGGCTGGAGATTGGGGTGCAGAGTGTCTATGAGGATGTGGCCAGAGATACCAACCGG
GGCCACACTGTGAAGGCAGTGTGCGAGTCCTTCCACCTGGCCAAAGATTCTGGCTTCAAA
GTGGTGGCTCACATGATGCCTGATCTGCCGAACGTGGGGCTGGAGAGAGACATTGAACAG
TTCACAGAGTTTTTCGAGAACCCAGCTTTCCGTCCTGACGGTTTGAAACTCTACCCTACC
CTGGTGATTCGTGGGACAGGGCTCTATGAGCTGTGGAAGTCAGGAAGATACAAGAGTTAT
TCCCCCAGCGACCTGATCGAGTTGGTGGCCCGGATCCTGGCCCTCGTGCCCCCGTGGACT
CGAGTGTACCGCGTGCAGAGAGATATTCCAATGCCGTTAGTCAGCTCAGGAGTGGAGCAC
GGAAACTTGAGAGAGCTGGCATTTGCAAGAATGAAAGACCTTGGAATACAGTGTCGTGAT
GTGAGAACCAGAGAGGTGGGAATCCAAGAAATTCATCACAAAGTCCGGCCATACCAGGTT
GAATTGGTGAGAAGAGATTATGTTGCAAATGGAGGCTGGGAAACCTTCTTATCGTATGAA
GACCCAGATCAGGACATCTTGATTGGCCTCCTGAGATTACGGAAGTGTTCAGAGGAGACA
TTCCGTTTCGAATTGGTTGGGGGTGTGTCCATAGTCCGAGAGCTGCACGTGTACGGAAGT
GTGGTTCCCGTAAGCAGTCGGGATCCCACTAAATTTCAGCATCAGGGCTTTGGCATGCTG
CTGATGGAGGAAGCAGAACGAATAGCCAGAGAAGAACATGGATCTGGGAAAATAGCTGTT
ATATCAGGGGTCGGCACCAGGAATTATTACAGAAAGATTGGCTACAGATTGCAAGGTCCA
TACATGGTAAAGACGCTAGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 547 |
| Molecular Weight
| 62331.0 |
| Theoretical pI
| 9.02 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Elongator complex protein 3
MRQKRKGDLSPAQLMMLTIGDVIKQLIEAHEQGKDIDLNKVKTRTAAKYGLSAQPRLVDI
IAAVPPQYRKVLVPKLKAKPIRTASGIAVVAVMCKPHRCPHISFTGNICVYCPGGPDSDF
EYSTQSYTGYEPTSMRAIRARYDPYLQTRHRIEQLKQLGHSVDKVEFIVMGGTFMALPEE
YRDYFIRNLHDALSGHTSNNIYEAVKYSERSLTKCIGITIETRPDYCMKRHLSDMLTYGC
TRLEIGVQSVYEDVARDTNRGHTVKAVCESFHLAKDSGFKVVAHMMPDLPNVGLERDIEQ
FTEFFENPAFRPDGLKLYPTLVIRGTGLYELWKSGRYKSYSPSDLIELVARILALVPPWT
RVYRVQRDIPMPLVSSGVEHGNLRELAFARMKDLGIQCRDVRTREVGIQEIHHKVRPYQV
ELVRRDYVANGGWETFLSYEDPDQDILIGLLRLRKCSEETFRFELVGGVSIVRELHVYGS
VVPVSSRDPTKFQHQGFGMLLMEEAERIAREEHGSGKIAVISGVGTRNYYRKIGYRLQGP
YMVKTLE
|
| External Links |
|---|
| GenBank ID Protein
| AAI05501.2 |
| UniProtKB/Swiss-Prot ID
| Q2KJ61 |
| UniProtKB/Swiss-Prot Entry Name
| ELP3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105500 |
| GeneCard ID
| ELP3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
