| Identification |
|---|
| BMDB Protein ID
| BMDBP00365 |
| Secondary Accession Numbers
| None |
| Name
| Trifunctional enzyme subunit beta, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| HADHB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity. |
| Pathways
|
- Fatty acid beta-oxidation
- Lipid metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| HADHB |
| Gene Sequence
|
>1428 bp
ATGATTTCCCTCTTGACTTACACTTTAAAAAATCTTCCCAATACATCAAAATGGGCCCTC
AGATTTTGTATGAGACCTCTGAGCAGTTCCTCCCAGCTACAAGCTGCCGCAGCTTCCCAG
ACTAAATCGAAAAAAACCCTAGCCAAACCCAACATAAGGAATATTGTGGTGGTGGATGGT
GTTCGCACTCCATTTTTGCTATCAGGCACTTCATATAAAGACCTGATGCCACATGATTTG
GCTAGAGCAGCACTTTCGGGTTTGTTGCATCGGACCAGTGTCCCAAAGGATGTTGTTGAT
TATATCATCTTTGGCACAGTTATACAGGAAGTGAAAACAAGCAATGTGGCTAGAGAGGCT
GCCCTCGGAGCCGGCTTCTCTGACAAGACTCCTGCTCACACTGTCACCATGGCTTGCATC
TCTTCCAACCAAGCCATGACCACAGCTGTCGGCCTGATTGCTTCCGGCCAATGTGACGTG
GTCGTGGCGGGTGGTGTAGAGTTGATGTCTGACATCCCTATTCGCCATTCAAGGAAAATG
AGGAAAATGATGCTGGATCTCAATAAGGCCAAGACTCTGGCTCAGCGACTCTCTATAATC
TCTAAATTCAGATTGAATTTCCTATCGCCAGAGCTTCCTGCAGTGAGTGAGTTCTCCACC
AGTGAGACCATGGGCCACTCTGCAGACCGACTGGCTGCTGCCTTTGCTATTTCTCGGGAG
GAGCAGGATGAATACGCATTGCGCTCTCACAGCCTGGCCAAAAAGGCACAGGATGAAGGA
CTCCTTTCTGATGTTGTGCCCTTCAAAGTACCAGGAAGAGATACAGTTACACAAGATAAT
GGGATTCGTCCTTCCTCTCTGGATCAGATGGCCAAACTAAAACCTGCATTCATCAAGCCC
TATGGCACAGTGACAGCTGCAAATTCTTCTTTCCTGACCGATGGTGCGTCTGCAGTGCTG
ATTATGGCAGAGGAAAAAGCTCTGGCCATGGGTTATAAGCCGAAGGCATATCTGAGGGAT
TTCATGTACGTGTCCCAGGATCCAAAAGATCAGCTTTTACTTGGACCAACGTATGCTACT
CCAAAAGTTCTGGAAAAGGCAGGATTAACAATGAATGATATTGATGTTTTTGAATTTCAT
GAAGCTTTCTCAGGTCAGATTTTGGCTAATTTGAAGGCCATGGATTCTGATTGGTTTGCA
CAAAACTACATGGGTAGAAAAGCCAAGGTTGGATTGCCTCCTTTGGAGAAGTTTAACAAC
TGGGGTGGATCACTGTCTCTGGGGCACCCATTTGGAGCCACTGGCTGTCGGTTGGTCATG
GCAGCTGCCAACAGGTTACGGAAGGAAGGAGGCCAGTATGGTCTAGTAGCTGCCTGTGCA
GCTGGAGGGCAGGGCCATGCTATGATAGTAGAAGCTTATCCAAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 475 |
| Molecular Weight
| 51345.0 |
| Theoretical pI
| 9.82 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 9-29
- 82-102
- 104-122
- 128-150
|
| Protein Sequence
|
>Trifunctional enzyme subunit beta, mitochondrial
MISLLTYTLKNLPNTSKWALRFCMRPLSSSSQLQAAAASQTKSKKTLAKPNIRNIVVVDG
VRTPFLLSGTSYKDLMPHDLARAALSGLLHRTSVPKDVVDYIIFGTVIQEVKTSNVAREA
ALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDVVVAGGVELMSDIPIRHSRKM
RKMMLDLNKAKTLAQRLSIISKFRLNFLSPELPAVSEFSTSETMGHSADRLAAAFAISRE
EQDEYALRSHSLAKKAQDEGLLSDVVPFKVPGRDTVTQDNGIRPSSLDQMAKLKPAFIKP
YGTVTAANSSFLTDGASAVLIMAEEKALAMGYKPKAYLRDFMYVSQDPKDQLLLGPTYAT
PKVLEKAGLTMNDIDVFEFHEAFSGQILANLKAMDSDWFAQNYMGRKAKVGLPPLEKFNN
WGGSLSLGHPFGATGCRLVMAAANRLRKEGGQYGLVAACAAGGQGHAMIVEAYPK
|
| External Links |
|---|
| GenBank ID Protein
| CAA05840.1 |
| UniProtKB/Swiss-Prot ID
| O46629 |
| UniProtKB/Swiss-Prot Entry Name
| ECHB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ003066 |
| GeneCard ID
| HADHB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
