1.0 2018-05-07 22:22:06 UTC 2020-05-20 21:04:07 UTC BMDBP00377 Enzyme NDST2 Involved in [heparan sulfate]-glucosamine N-sulfotransf Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). Glycan metabolism Heparan sulfate biosynthesis. Heparin biosynthesis BMDB0000061 Adenosine 3',5'-diphosphate BMDB0001134 Phosphoadenosine phosphosulfate 28 >2655 bp ATGCTCAAGCTGTGGAAGGTGGTACGCCCAGCTCGGCAGTTGGAACTGCACCGCCTCATA CTGCTGCTGATTGCTTTCAGTCTGGGCTCCATGGGCTTCTTGGCTTACTACGTATCCACC AGCCCCAAGGCCAAGGAACCGTTGCCVCTCCCCTTGGGAGACTGCAGCAGTAGTGGCGCA GCGGGTGGTCCTGGCCCGGTTCGGCCTCCAGTCCCACCACGCCCCCCCAGGCCTCCAGAG ACAGCGCGAACTGAACCCGTGGTCCTTGTGTTTGTGGAGAGTGCATACTCGCAGCTGGGG CAGGAGATCGTGGCCATCTTGGAGTCTAGCCGTTTTCGTTACAGCACTGAGCTGGCACCT GGCCGAGGGGACATGCCCACACTGACGGATCATACCCGGGGCCGGTATGTCTTGGTCATT TATGAGAACCTGCTCAAGTACGTCAACCTGGATGCCTGGAGTCGGGAACTGCTAGACCGG TACTGTGTGGAGTACGGTGTAGGCATCATTGGCTTTTTTCGAGCCCATGAGCACAGCCTA CTGAGTGCCCAGCTCAAGGGCTTTCCCCTTTTTCTCCATTCAAACTTGGGGCTTCGGGAC TACCAAGTGAATCCTACAGCTCCACTCCTACATCTCACACGTCCCAGCCGCCTGGAGCCT GGGCCACTACCCGGTGATGACTGGACCATCTTCCAATCCAACCACAGGACCTATGAACCA GTGCTTCTTGGCAGCCTTCGGCCGGCTGAGCCCCCTGTGCCAGGACCAGTGGCTCGGCGG GCCCGGCTTCCCACTGTGGTGCAGGACCTGGGGGTTCACGATGGAATCCAGAGGGTGCTG TTTGGGCACGGGCTCTCCTTCTGGCTCCACAAACTAGTTTTCCGCGATGCCGGTGGGTAC CTCACTGGCAAGGGGCTCTTGTGGGACTTGGACCGTTACATCTTGGTAGACATCGATGAC ATCTTTGTGGGCAAGGAAGGTACCCGCATGAAGGTGGCTGATGTTGAGGCCCTGTTGACC ACGCAGAACAAACTCAGGACCTTAGTCCCCAACTTCACCTTCAACTTGGGCTTCTCGGGC AAGTTCTATCATACTGGGACAGAGGAGGAGGATGCTGGGGACGACATGCTGCTGAATCAC CGCCGAGAGTTCTGGTGGTTCCCCCACATGTGGAGCCACATGCAGCCACATCTGTTCCAC AATCGCTCCGTGCTGGCTGACCAGATGAGGCTCAACAAACAGTTTGCTCTGGAACATGGG ATTCCCACGGATCTGGGGTATGCTGTGGCCCCCCACCACTCCGGCGTGTACCCCATCCAC ACACAGCTCTATGAAGCCTGGAAATCTGTGTGGGGCATCCAGGTGACCAGCACTGAGGAG TACCCCCACCTCCGCCCTGCCCGCTACCGCCGCGGCTTCATTCACAATGGCATTATGGTG CTGCCGCGGCAGACATGTGGCCTCTTCACTCACACAATCTTCTATAATGAGTATCCAGGA GGCTCTCGTGAACTCGACCGGAGTATCCGAGGTGGAGAACTCTTTCTGACAGTGCTGCTT AATCCGATCAGCATCTTTATGACTCATCTGTCGAACTATGGAAATGATCGCCTGGGTCTG TACACCTTTGAGAGCCTGGTGCGCTTTCTCCAGTGCTGGACGAGCCTGCGCCTACAGACC CTTCCTCCTGTCCCTCTTGGGCGAAAGTACTTTGACCTCTTCCCTCAAGAGCGAAGCCCC CTTTGGCAGAATCCCTGTGACGACAAGAGGCACAAAGATATCTGGTCCAAGGAGAAAACC TGTGATCGCCTCCCCAAGTTCCTCATTGTGGGACCCCAGAAGACAGGGACCACAGCTATT CACTTCTTCCTGAGCCTGCATCCAGCTGTGACTAGCAGTTTTCCTAGCCCCAGCACCTTT GAGGAGATTCAGTTCTTCAACGGCCCTAATTACCACAAGGGCATTGACTGGTACATGGAT TTCTTCCCTGTCCCTTCCAATGCCAGCACTGATTTCCTATTTGAAAAAAGTGCCACGTAC TTTGACTCAGAGGTTGTACCACGGCGGGGAGCTGCCCTCCTGCCACGAGCCAAGATCATC ACTGTGCTCACCAACCCTGCTGACAGGGCATACTCCTGGTACCAGCATCAGCGAGCACAT GGAGACCCAGTTGCTCTGAACTACACCTTCTACCAGGTGATTACAGCCTCCTCCCAGGAC CCTCCAGCACTTCGCTCCCTACAAAACCGTTGTCTTGTCCCCGGCTACTATTCCACTCAC TTACAACGCTGGCTGACTTACTACCCCTCTGGACAGTTGCTGATTGTGGATGGGCAAGAG CTGCGTACCAACCCAGCTGCCTCAATGGAGATCATCCAGAAGTTCCTGGGTATCACACCC TTTCTGAACTACACACGGACCCTCAGGTTCGATGAAGATAAGGGATTCTGGTGCCAGGGA CTTGAAGGTGGCAAGACTCGTTGTCTAGGAAAGAGCAAAGGTCGGAAGTACCCAGATATG GACGCTGAGTCCCGCCTTTTCCTTACGGATTTTTTCCGGAACCACAATTTGGAGCTGTCA AAGCTGCTGAGCCGGCTTGGACAGCCAGTGCCCTCATGGCTTCGAGAAGAACTGCAGCAT TCCAGTTCGGGCTGA 884 100897.0 8.94 19-39 None >Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 MLKLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSSGA AGGPGPVRPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAP GRGDMPTLTDHTRGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSL LSAQLKGFPLFLHSNLGLRDYQVNPTAPLLHLTRPSRLEPGPLPGDDWTIFQSNHRTYEP VLLGSLRPAEPPVPGPVARRARLPTVVQDLGVHDGIQRVLFGHGLSFWLHKLVFRDAGGY LTGKGLLWDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSG KFYHTGTEEEDAGDDMLLNHRREFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHG IPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMV LPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGL YTFESLVRFLQCWTSLRLQTLPPVPLGRKYFDLFPQERSPLWQNPCDDKRHKDIWSKEKT CDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNGPNYHKGIDWYMD FFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAH GDPVALNYTFYQVITASSQDPPALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQE LRTNPAASMEIIQKFLGITPFLNYTRTLRFDEDKGFWCQGLEGGKTRCLGKSKGRKYPDM DAESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSSG AAC77921.1 O97583 NDST2_BOVIN AF064825 NDST2