| Identification |
|---|
| BMDB Protein ID
| BMDBP00418 |
| Secondary Accession Numbers
| None |
| Name
| Histone-lysine N-methyltransferase EZH1 |
| Synonyms
|
Not Available
|
| Gene Name
| EZH1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| EZH1 |
| Gene Sequence
|
>2124 bp
ATGGATATACCAAATCCCCCGACGTCCAAATGTATCACTTACTGGAAGAGGAAAGTTAAG
TCTGAATACATGCGACTTCGGCAGCTTAAACGGCTTCAGGCGAATATGGGTGCAAAGGCT
CTCTATGTAGCAAATTTTGCAAAAGTTCAAGAAAAAACCCAGATCCTCAATGAAGAATGG
AAGAAGCTTCGTGTCCAACCTGTTCAGTTAATGAAGCCTGTGAGTGGGCATCCTTTTCTC
AAAAAGTGTACCATAGAGAGCATTTTCCCGGGATTTGCAAGCCAGCACATGTTAATGAGG
TCTCTGAACACAGTTGCCTTGGTTCCCATCATGTACTCGTGGTCCCCTCTCCAGCAGAAC
TTCATGGTGGAAGATGAGACAGTTTTGTGCAATATCCCCTACATGGGAGATGAGGTGAAA
GAGGAAGATGAGACTTTCATTGAGGAGCTGATCAATAACTACGATGGCAAAGTCCACGGT
GAAGAAGAGATGATTCCTGGCTCTGTCCTGATCAGTGATGCTGTTTTCCTGGAGTTGGTA
GATGCTCTGAATCAATACTCAGATGAAGATGAAGAAGGGCACAACGACACCTCAGATGGA
AAGCAAGATGACAGCAAAGAGGATCTGCCAGTAACAAGAAAGAGGAAACGACATGCTATT
GAAGGCAGCAAAAAGAGTTCCAAGAAACAATTCCCAAACGACATGATCTTCAGTGCGATC
GCCTCGATGTTCCCTGAGAACGGTGTCCCAGACGACATGAAGGAGAGGTACCGAGAGCTC
ACAGAGATGTCAGACCCCAATGCGCTCCCCCCGCAGTGCACACCCAACATCGACGGCCCC
AACGCCAAGTCTGTGCAGCGGGAACAGTCTCTGCACTCCTTCCACACACTCTTCTGCCGG
CGCTGCTTCAAATACGACTGCTTCCTTCACCCTTTCCATGCCACCCCTAATGTGTATAAA
CGCAAGAACAAAGAAATCAAGATTGAGCCAGAACCGTGTGGCACAGACTGCTTCCTTCTG
CTGGAAGGAGCAAAGGAGTACGCCATGCTGCACAACCCTCGCTCCAAGTGCTCTGGGCGT
CGCCGGCGAAGGCACCACGTGGTCAATGCCTCCTGCTCCAACACTTCAGCCTCTGCTGTG
GCTGAGACCAAAGAAGGGGACAGCGACAGGGACACTGGCAATGACTGGGCCTCCAGTTCT
TCAGAGGCAAACTCACGCTGTCAGACGCCCACGAAACAGAAGGCGAGTCCAGCCCCACCT
CAGCTCTGTGTCGTGGAAGCACCCTCAGAACCTGTGGAGTGGACTGGGGCTGAAGAATCT
CTTTTTCGAGTCTTTCATGGCACCTACTTCAACAACTTCTGTTCAATAGCCAGACTTCTG
GGGACTAAGACATGCAAGCAGGTCTTCCAGTTTGCAGTCAAAGAGTCACTTATCCTGAAG
CTGCCCACAGATGAGCTTATGAACCCCTCGCAGAAGAAGAAGAGAAAGCACAGGTTGTGG
GCTGCACACTGCCGGAAAATTCAGCTGAAGAAAGATAACTCCTCCACCCAGGTGTACAAC
TACCAGCCCTGCGACCACCCGGACCGCCCCTGTGACAGCACGTGCCCCTGCATCATGACT
CAGAATTTCTGTGAGAAGTTCTGCCAGTGCAACCCCGACTGTCAGAATCGCTTTCCCGGC
TGTCGCTGTAAGACCCAGTGCAATACCAAGCAGTGCCCGTGCTACCTGGCGGTGCGCGAG
TGTGACCCTGACCTGTGCCTCACCTGTGGGGCCTCGGAGCACTGGGACTGCAAGGTGGTT
TCCTGTAAGAACTGCAGCATTCAACGTGGCCTCAAAAAGCACCTGCTGCTGGCCCCCTCA
GATGTGGCCGGATGGGGCACCTTCATTAAGGAGTCTGTGCAGAAGAATGAATTCATTTCT
GAATACTGTGGTGAGCTCATCTCTCAGGATGAGGCCGATCGACGAGGGAAGGTCTATGAC
AAGTACATGTCCAGCTTCCTCTTCAACCTCAATAACGATTTTGTAGTGGATGCTACCCGG
AAAGGAAACAAAATTCGATTTGCAAACCATTCGGTGAACCCCAACTGTTATGCCAAAGCC
AAAATAACAGATCTAAAAGCATAG
|
| Protein Properties |
|---|
| Number of Residues
| 747 |
| Molecular Weight
| 85285.0 |
| Theoretical pI
| 7.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Histone-lysine N-methyltransferase EZH1
MDIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQLMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEDEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGSKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHVVNASCSNTSASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
|
| External Links |
|---|
| GenBank ID Protein
| AAI51627.1 |
| UniProtKB/Swiss-Prot ID
| A7E2Z2 |
| UniProtKB/Swiss-Prot Entry Name
| EZH1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC151626 |
| GeneCard ID
| EZH1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
