<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:22:19 UTC</creation_date>
  <update_date>2020-05-20 21:11:45 UTC</update_date>
  <accession>BMDBP00424</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>HYAL2</gene_name>
  <general_function>Involved in hyalurononglucosaminidase activity</general_function>
  <specific_function>Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product which is further hydrolyzed by sperm hyaluronidase to give small oligosaccharides. Displays very low levels of activity. Associates with and negatively regulates MST1R (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000127</accession>
      <name>D-Glucuronic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000803</accession>
      <name>Beta-N-Acetylglucosamine</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0010366</accession>
      <name>Hyaluronan</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>22</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1422 bp
ATGTGGACAGGCCTGGGCCCCGCCGTCACACTGGCCCTGGTGTTGGTGGTGGCATGGGCC
ACGGAGCTGAAGCCCACAGCACCACCCATCTTCACGGGCCGGCCCTTTGTGGTCGCATGG
GATGTGCCCACACAGGACTGTGGCCCGCGCCACAAGATGCCATTGGACCCAAAGGACATG
AAGGCCTTTGATGTTCAGGCTTCACCTAACGAGGGTTTTGTAAATCAGAACATCACCATC
TTCTACCGTGACCGGCTGGGCATGTATCCACACTTCAATTCGGTGGGGAGGTCAGTACAT
GGTGGTGTGCCACAGAATGGCAGCCTCTGGGTACACCTGGAGATGCTGAAGGGACACGTG
GAACACTACATTCGTACACAGGAGCCTGCAGGGCTGGCAGTCATCGACTGGGAGGACTGG
CGGCCAGTGTGGGTGCGCAACTGGCAGGACAAGGATGTGTACCGCCGATTATCACGCCAT
TTGGTAGCCATTCGCCACCCTGATTGGCCACCAGAGCGCGTAGCCAAGGAGGCGCAGTAT
GAGTTTGAGTTCGCTGCACGGCAGTTCATGCTGGAGACATTGCGATTTGTCAAGGCGTTT
CGGCCTCGGCACCTATGGGGCTTCTACCTCTTCCCTGACTGTTACAACCATGATTATGTG
CAGAACTGGGAGACCTATACAGGCCGCTGCCCTGATGTTGAGGTCTCCCGAAATGACCAG
CTGGCCTGGCTCTGGGCCGAGAGCACGGCCCTCTTCCCCTCTGTCTACTTGGAAGAGACA
CTGGCTTCCTCCACTCACGGCCGCAACTTTGTCAGCTTTCGTGTCCAGGAGGCTCTTCGC
GTGGCTGACGTCCACCATGCCAACCATGCACTCCCCGTCTACGTCTTCACGAGGCCCACC
TATAGCCGTGGACTCACAGGGCTTAGCGAGATGGATCTCATCTCCACCATTGGTGAGAGT
GCTGCCCTGGGTGCAGCTGGCGTCATCCTCTGGGGTGACGCAGGGTTTACCACCAGCAAC
GAGACCTGCCGACGCCTCAAGGATTATCTGACTCGGTCATTGGTACCCTATGTCGTCAAT
GTGTCCTGGGCTGCCCAGTACTGCAGCTGGGCCCAGTGCCATGGCCATGGGCGCTGTGTG
CGCCGGGACCCCAACGCTCACACCTTCCTGCACCTCAGTGCCAGCAGCTTCCGTCTAGTG
CCTAGCCACGCACCTGATGAGCCGCGGCTGCGACCAGAGGGGGAACTCAGTTGGGCCGAC
CGCAACCACCTACAGATGCACTTTCGCTGCCAGTGCTACTTAGGCTGGGGCGGTGAGCAA
TGCCAGTGGGACCGCAGGCGGGCAGCTGGGGGTGCCAGTGGGGCCTGGGCTGGGTCCCAC
CTCACTGGCCTGCTGGCAGTGGCAGTCCTGGCCTTCACCTAG</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>473</residue_number>
    <molecular_weight>53881.0</molecular_weight>
    <theoretical_pi>7.66</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>1-20</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Hyaluronidase-2
MWTGLGPAVTLALVLVVAWATELKPTAPPIFTGRPFVVAWDVPTQDCGPRHKMPLDPKDM
KAFDVQASPNEGFVNQNITIFYRDRLGMYPHFNSVGRSVHGGVPQNGSLWVHLEMLKGHV
EHYIRTQEPAGLAVIDWEDWRPVWVRNWQDKDVYRRLSRHLVAIRHPDWPPERVAKEAQY
EFEFAARQFMLETLRFVKAFRPRHLWGFYLFPDCYNHDYVQNWETYTGRCPDVEVSRNDQ
LAWLWAESTALFPSVYLEETLASSTHGRNFVSFRVQEALRVADVHHANHALPVYVFTRPT
YSRGLTGLSEMDLISTIGESAALGAAGVILWGDAGFTTSNETCRRLKDYLTRSLVPYVVN
VSWAAQYCSWAQCHGHGRCVRRDPNAHTFLHLSASSFRLVPSHAPDEPRLRPEGELSWAD
RNHLQMHFRCQCYLGWGGEQCQWDRRRAAGGASGAWAGSHLTGLLAVAVLAFT</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAL78385.1</genbank_protein_id>
  <uniprot_id>Q8SQG8</uniprot_id>
  <uniprot_name>HYAL2_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>AF411973</genbank_gene_id>
  <genecard_id>HYAL2</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
