| Identification |
|---|
| BMDB Protein ID
| BMDBP00500 |
| Secondary Accession Numbers
| None |
| Name
| Diphosphoinositol polyphosphate phosphohydrolase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| NUDT3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity). |
| Pathways
|
- Inositol Phosphate Metabolism
|
| Reactions
|
| 5-Diphosphoinositol pentakisphosphate + Water → Myo-inositol hexakisphosphate + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| NUDT3 |
| Gene Sequence
|
>519 bp
ATGATGAAGCTCAAGTCGAACCAGACCCGCACCTATGACGGCGACGGCTACAAGAAGCGG
GCCGCGTGCCTGTGTTTCCGCAGCGAGAGTGAGGAGGAGGTGCTACTTGTGAGCAGCAGT
CGTCATCCAGACCGGTGGATCGTCCCTGGAGGGGGCATGGAGCCCGAGGAGGAGCCGGGC
ACCGCCGCAGTCCGTGAAGTCTGTGAGGAGGCTGGAGTAAAAGGGACATTGGGAAGATTA
GTTGGAATTTTTGAGAACCAGGAGAGGAAGCATAGAACGTATGTCTATGTGCTCATTGTC
ACAGAAGTGCTGGAAGACTGGGAAGACTCGGTCAGCATCGGAAGGAAGCGGGAATGGTTT
AAAATAGAAGATGCCATAAACGTGCTGCAGTGTCACAAACCGGTGCAGGCCTCGTATTTT
GAAACGTTGAGACAAGGCTACTCAGCCAACAACGGCACCCCGCTCGTGGCCCCCACATAC
TCAGTATCTGCTCAGAGCTCGATGCCAGGCATCAGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 172 |
| Molecular Weight
| 19362.0 |
| Theoretical pI
| 5.77 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Diphosphoinositol polyphosphate phosphohydrolase 1
MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPG
TAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVSIGRKREWF
KIEDAINVLQCHKPVQASYFETLRQGYSANNGTPLVAPTYSVSAQSSMPGIR
|
| External Links |
|---|
| GenBank ID Protein
| AAI33615.1 |
| UniProtKB/Swiss-Prot ID
| A2VE79 |
| UniProtKB/Swiss-Prot Entry Name
| NUDT3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133614 |
| GeneCard ID
| NUDT3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
