| Identification |
|---|
| BMDB Protein ID
| BMDBP00502 |
| Secondary Accession Numbers
| None |
| Name
| TGF-beta receptor type-1 |
| Synonyms
|
Not Available
|
| Gene Name
| TGFBR1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| Not Available |
| SNPs
| TGFBR1 |
| Gene Sequence
|
>1500 bp
ATGGAGGCAGCGGCCGCTACTCCGCGTCCCCGGCTGTTCCTCCTCATGCTGGCGGCGGCG
GCCACGCTGGTCCCGGAGGCAACGCCATTACAGTGTTTTTGCCACCTTTGTACAAAAGAC
AATTTTACTTGTGTCACAGATGGGCTTTGCTTTGTTTCTGTCACAGAGACCACAGACAAA
GTTATACATAATAGCATGTGTATAGCTGAAATTGACCTAATTCCACGAGACAGGCCATTT
GTATGTGCACCATCTTCAAAAACTGGGTCTATAACTACAACATATTGCTGCAACCAGGAC
CACTGCAATAAAATAGAACTTCCAACTGTTGGAAAGCCATCATCTGGCCTTGGTCCTGTT
GAACTGGCAGCTGTCATTGCTGGACCAGTCTGCTTTGTCTGTATCTCACTCATGTTGATG
GTCTATATTTGCCATAACCGCACTGTCATTCACCATCGAGTGCCAAATGAAGAGGATCCC
TCGTTAGATCGCCCTTTTATTTCAGAGGGTACAACGTTAAAAGATTTAATTTACGACATG
ACAACATCAGGTTCTGGATCAGGTTTACCATTGCTTGTTCAGAGAACAATTGCGAGAACT
ATTGTGTTACAAGAAAGTATTGGCAAAGGTCGTTTTGGAGAAGTTTGGCGAGGAAAATGG
AGAGGAGAAGAAGTTGCTGTTAAAATATTCTCCTCTAGAGAAGAACGTTCATGGTTCCGT
GAAGCAGAGATTTATCAGACTGTCATGTTACGTCACGAAAACATCTTGGGATTTATAGCA
GCAGACAATAAAGACAATGGCACATGGACTCAGCTCTGGTTGGTGTCAGATTATCATGAG
CACGGATCCCTTTTTGATTATTTGAACAGATACACAGTTACTGTGGAAGGAATGATAAAA
CTTGCTCTGTCCACAGCAAGTGGACTTGCCCATCTTCACATGGAGATAGTTGGTACCCAA
GGAAAACCAGCCATAGCTCATAGGGATTTGAAATCAAAGAATATCTTGGTAAAGAAGAAT
GGAACTTGCTGTATTGCAGACTTAGGATTGGCAGTAAGGCATGATTCGGCCACGGATACA
ATTGACATTGCTCCAAACCACAGAGTGGGAACAAAAAGGTACATGGCCCCTGAAGTTCTA
GATGATTCCATAAATATGAAACACTTTGAATCCTTCAAACGTGCTGACATCTATGCAATG
GGACTAGTATTCTGGGAAGTAGCTCGACGATGTTCCATTGGTGGAATACATGAAGATTAC
CAGCTGCCTTATTATGATCTTGTACCTTCCGATCCATCAGTTGAAGAAATGAGAAAAGTT
GTTTGTGAACAGAAGTTAAGGCCAAATATTCCAAACAGATGGCAGAGCTGTGAAGCCTTG
AGAGTAATGGCTAAAATTATGAGAGAATGTTGGTATGCCAATGGAGCAGCTAGGCTTACA
GCTTTGCGGATTAAGAAAACATTGTCACAACTCAGTCAGCAGGAAGGCATCAAAATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 499 |
| Molecular Weight
| 55814.0 |
| Theoretical pI
| 7.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>TGF-beta receptor type-1
MEAAAATPRPRLFLLMLAAAATLVPEATPLQCFCHLCTKDNFTCVTDGLCFVSVTETTDK
VIHNSMCIAEIDLIPRDRPFVCAPSSKTGSITTTYCCNQDHCNKIELPTVGKPSSGLGPV
ELAAVIAGPVCFVCISLMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDM
TTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFR
EAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIK
LALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDT
IDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEVARRCSIGGIHEDY
QLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLT
ALRIKKTLSQLSQQEGIKM
|
| External Links |
|---|
| GenBank ID Protein
| AAC02717.1 |
| UniProtKB/Swiss-Prot ID
| O46680 |
| UniProtKB/Swiss-Prot Entry Name
| TGFR1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U97485 |
| GeneCard ID
| TGFBR1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
