| Identification |
|---|
| BMDB Protein ID
| BMDBP00546 |
| Secondary Accession Numbers
| None |
| Name
| Type II iodothyronine deiodinase |
| Synonyms
|
Not Available
|
| Gene Name
| DIO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in selenium binding |
| Specific Function
| Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| DIO2 |
| Gene Sequence
|
>810 bp
ATGGGCATCCTCAGCGTAGACTTGCTGATCACACTGCAGATTCTGCCAGTTTTTTTCTCC
AACTGCCTCTTCCTGGCGCTCTATGACTCGGTCATTCTCCTCAAGCACGTGGTGCTGCTG
CTGAGCCGCTCCAAGTCCACTCGCGGGCAGTGGAGGCGCATGCTGACCTCAGAAGGAATG
CGCTGCATCTGGAAAAGCTTCCTCCTCGACGCCTACAAACAGGTGAAACTGGGTGAAGAT
GCCCCCAATTCCAGCGTGGTGCATGTCTCCAGTCCGGAAGGAGGTGACACCAGTGGAAAT
GGTGCCCAGGAGAAAACAGTGGATGGAACTGAATGCCACCTTCTGGACTTTGCCAGCCCT
GAGCGCCCACTGGTGGTCAACTTCGGCTCGGCCACTTGACCTCCTTTCACTAACCAGCTG
CCAGCCTTCAGCAAACTGGTGGAAGAGTTCTCATCCGTGGCTGACTTCCTGTTGGTCTAC
ATTGATGAGGCTCATCCTTCAGATGGTTGGGCAGTGCCTGGGGATTCTTCTTTGTTTTTC
GAGGTGAAGAAGCACCGGAACCAGGAAGACCGATGCGCAGCAGCCCACCAGCTCCTGGAG
CGTTTCTCCTTGCCGCCCCAGTGCCGAGTTGTGGCTGACCGCATGGACAATAATGCCAAC
GTTGCTTATGGGGTAGCCTTTGAACGTGTGTGCATCGTGCAGAGACAGAAAATTGCTTAT
CTGGGAGGAAAGGGCCCCTTCTTTTACAACCTGCAAGAAGTCCGGCGTTGGCTGGAGAAG
AATTTCAGCAAGAGATGAAAGCTAGATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 269 |
| Molecular Weight
| 30303.0 |
| Theoretical pI
| 7.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Type II iodothyronine deiodinase
MGILSVDLLITLQILPVFFSNCLFLALYDSVILLKHVVLLLSRSKSTRGQWRRMLTSEGM
RCIWKSFLLDAYKQVKLGEDAPNSSVVHVSSPEGGDTSGNGAQEKTVDGTECHLLDFASP
ERPLVVNFGSATUPPFTNQLPAFSKLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLFF
EVKKHRNQEDRCAAAHQLLERFSLPPQCRVVADRMDNNANVAYGVAFERVCIVQRQKIAY
LGGKGPFFYNLQEVRRWLEKNFSKRUKLD
|
| External Links |
|---|
| GenBank ID Protein
| AAW51123.1 |
| UniProtKB/Swiss-Prot ID
| Q5I3B2 |
| UniProtKB/Swiss-Prot Entry Name
| IOD2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY858551 |
| GeneCard ID
| DIO2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
