| Identification |
|---|
| BMDB Protein ID
| BMDBP00558 |
| Secondary Accession Numbers
| None |
| Name
| Arginase-2, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ARG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity. |
| Pathways
|
- L-ornithine and urea from L-arginine: step 1/1
- Nitrogen metabolism
- Urea Cycle
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| ARG2 |
| Gene Sequence
|
>1065 bp
ATGTCCCTGAGGAGCCACCTCTCGCGTCTCCTCCGGACGCAAGTGCACTCCGTCCGGAAG
AAGTCTGTCCACTCCGTGGCTGTCATTGGAGCCCCATTCTCCCAGGGACAGAAAAGAAAA
GGAGTGGAATATGGTCCTGCTGCTGTAAGANAAGCTGGCTTGATGAAAAGGCTCTCGGAT
CTGGGCTGCCACCTTAAAGACTTCGGAGATTTGAATTTTACTCCAGTTCCCAAAGATGAT
CTCTATAACAACTTGATAGTGAATCCTCGCTCAGTGGGCCTGGCCAACCAGGAACTAGCG
GAGGTGGTTAGCCGAGCTGTGTCAGGTGGCTACAGCTGTGTCACGGTGGGAGGAGACCAC
AGCCTGGCAATCGGTACCATCAGTGGCCACGCCCGACACTGCCCAGACCTTGGTGTGATC
TGGGTTGATGCCCATGCTGACATCAATACACCCCTCACCACTTCATCTGGAAATCTACAT
GGACAGCCAGTTTCGTTTCTCCTCAGAGAACTACAGGACAAGGTACCACAGCTCCCAGGA
TTTTCCTGGATCAAACCTTGTATCTCTTCTCCAAGTATTGTATATATTGGACTAAGAGAC
GTGGACCCTCCTGAACATTTTATTTTAAAGAATTATGATATCCAGTATTTTTCCATGAGA
GACATAGATCGACTTGGTATCCAGAAGGTCATGGAACAGACATTCGATCTGCTGATTGGC
AAAAGACAAAGGCCAATCCATCTGAGTTTCGATATTGATGCATTTGACCCTACACTGGCT
CCAGCCACAGGAACCCCTGTTGTAGGGGGACTGACCTATCGAGAAGGCATATATATTACT
GAGGAAATACACAGTACAGGGTTGCTCTCGGCCCTGGACCTCGTTGAAGTCAATCCTCGG
TTGGCCGTGTCAGAGGAGGAGGCCAAGGCTACAGCCAGCCTGGCAGTGGACGTCATTGCT
TCGAGTTTCGGGCAGACGAGGGAGGGAGGGCATATTGTCTACGACCAACTTCCAACTCCC
AGCTCACCAGATGAATCAGAGAGTGAAGAACGTGTAAGAATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 38616.0 |
| Theoretical pI
| 6.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Arginase-2, mitochondrial
MSLRSHLSRLLRTQVHSVRKKSVHSVAVIGAPFSQGQKRKGVEYGPAAVRXAGLMKRLSD
LGCHLKDFGDLNFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSGGYSCVTVGGDH
SLAIGTISGHARHCPDLGVIWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPG
FSWIKPCISSPSIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMEQTFDLLIG
KRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGIYITEEIHSTGLLSALDLVEVNPR
LAVSEEEAKATASLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESESEERVRI
|
| External Links |
|---|
| GenBank ID Protein
| AAX46433.1 |
| UniProtKB/Swiss-Prot ID
| Q58DL1 |
| UniProtKB/Swiss-Prot Entry Name
| ARGI2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT021586 |
| GeneCard ID
| ARG2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
