| Identification |
|---|
| BMDB Protein ID
| BMDBP00567 |
| Secondary Accession Numbers
| |
| Name
| Aspartate aminotransferase, cytoplasmic |
| Synonyms
|
Not Available
|
| Gene Name
| GOT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). |
| Pathways
|
Not Available
|
| Reactions
|
| 3-Sulfinoalanine + Oxoglutaric acid → 3-Sulfinylpyruvic acid + L-Glutamic acid |
details
|
| L-Cysteine + Oxoglutaric acid → 3-Mercaptopyruvic acid + L-Glutamic acid |
details
|
| L-Phenylalanine + Oxoglutaric acid → Phenylpyruvic acid + L-Glutamic acid |
details
|
| Oxoglutaric acid + L-Aspartic acid → Oxalacetic acid + L-Glutamic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| GOT1 |
| Gene Sequence
|
>1242 bp
ATGGCGCCTCCATCAATCTTTGCCGAGGTTCCTCAGGCCCAGCCGGTCCTTGTCTTTAAG
CTAACTGCTGACTTCCGGGAGGATCCGGACCCCCGCAAGGTCAACCTGGGAGTGGGAGCT
TATCGCACCGATGATAGCCAGCCCTGGGTTTTACCAGTCGTGAGGAAGGTGGAGCAGAGG
ATTGCTAACGACAGCAGCATAAACCATGAGTATCTGCCCATCCTGGGCCTGGCAGAGTTC
CGAACTTGTGCTTCCCGCCTGGCCCTTGGGGATGACAGCCCAGCTCTGCAAGAGAAGCGG
GTGGGAGGGGTGCAGTGCTTGGGGGGAACAGGTGCACTTCGAATCGGAGCTGAGTTCTTG
GCGCGCTGGTACAATGGAACAAACAACAAGGACACACCCGTCTATGTGTCCTCGCCAACC
TGGGAGAATCATAATGGTGTCTTTATTGCTGCTGGATTTAAAGACATTCGGTCCTATCAC
TATTGGGATGCAGCGAAGAGAGGACTAGACCTCCAGGGTTTCCTGAATGATTTGGAGAAA
GCTCCCGAGTTCTCCATCTTTGTCCTCCATGCCTGTGCGCACAACCCGACTGGGACTGAC
CCGACTCCGGAGCAGTGGAAGCAGATCGCCTCCGTCATGAAGCGCCGGTTTCTGTTCCCC
TTCTTTGACTCGGCCTATCAGGCGTTCGCATCTGGCAGCCTGGAGAAAGACGCCTGGGCC
ATTCGCTATTTTGTGTCTGAAGGGTTCGAGCTCTTCTGTGCCCAGTCCTTCTCCAAAAAC
TTCGGGCTCTACAATGAGCGTGTGGGGAATCTGACTGTGGTTGCCAAAGAACCAGATAGC
ATCCTGCGGGTCCTTTCCCAGATGGAGAAGATCGTGCGAATTACATGGTCCAATCCCCCA
GCTCAGGGAGCACGGATCGTGGCACGTACCCTGTCTGATCCTGAGCTCTTTAATGAATGG
ACAGGTAACGTGAAGACAATGGCAGACCGCATTCTGACCATGAGATCTGAGCTCAGGGCA
CGATTAGAAGCCCTCAAGACCCCAGGAACCTGGAACCACATCACAGAGCAGATCGGAATG
TTCAGCTTCACCGGGTTGAACCCCAAGCAGGTTGAGTATCTGATCAATGAAAAGCACATC
TATCTGCTGCCAAGTGGTCGGATCAACATGTGTGGCTTAACCACCAAAAATCTAGAGTAC
GTGGCCACCTCCATCCATGAAGCAGTCACCAAAATCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 413 |
| Molecular Weight
| 46399.0 |
| Theoretical pI
| 7.56 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Aspartate aminotransferase, cytoplasmic
MAPPSIFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDSQPWVLPVVRKVEQR
IANDSSINHEYLPILGLAEFRTCASRLALGDDSPALQEKRVGGVQCLGGTGALRIGAEFL
ARWYNGTNNKDTPVYVSSPTWENHNGVFIAAGFKDIRSYHYWDAAKRGLDLQGFLNDLEK
APEFSIFVLHACAHNPTGTDPTPEQWKQIASVMKRRFLFPFFDSAYQGFASGSLEKDAWA
IRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVAKEPDSILRVLSQMEKIVRITWSNPP
AQGARIVARTLSDPELFNEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITEQIGM
FSFTGLNPKQVEYLINEKHIYLLPSGRINMCGLTTKNLEYVATSIHEAVTKIQ
|
| External Links |
|---|
| GenBank ID Protein
| CAA46818.1 |
| UniProtKB/Swiss-Prot ID
| P33097 |
| UniProtKB/Swiss-Prot Entry Name
| AATC_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X66020 |
| GeneCard ID
| GOT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
