| Identification |
|---|
| BMDB Protein ID
| BMDBP00581 |
| Secondary Accession Numbers
| None |
| Name
| Pseudouridylate synthase 7 homolog |
| Synonyms
|
Not Available
|
| Gene Name
| PUS7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in pseudouridine synthase activity |
| Specific Function
| Pseudouridylate synthase that catalyzes pseudouridylation of RNAs. Acts as a regulator of protein synthesis in embryonic stem cells by mediating pseudouridylation of RNA fragments derived from tRNAs (tRFs): pseudouridylated tRFs inhibit translation by targeting the translation initiation complex. Also catalyzes pseudouridylation of mRNAs: mediates pseudouridylation of mRNAs with the consensus sequence 5'-UGUAG-3'. In addition to mRNAs and tRNAs, binds other types of RNAs, such as snRNAs, Y RNAs and vault RNAs, suggesting that it can catalyze pseudouridylation of many RNA types. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| PUS7 |
| Gene Sequence
|
>1980 bp
ATGGAGATGACAGAAATGACTAGTGTGTCATTGAAACGGGGGTCCGTTGCCATCGAAGAT
AATGACAGTGTGGCCCCAGCTGAGGAGGCCAAGAGACAGAAGGTCTCAGGATGCTGTCCA
ACCACAGGTCAAGATGGGATAGAGAACAGCTCTCTACCCAGCAGCGAAAAGGTGCCTGGG
CCTCCCGAAACTGCTGAACAGGGTGAAAAGAACTCTGAGGTTCCCTCAGAGGAAGAGGAG
GAGGAAGATGGCCTCTCAGAGGAGGAGGAGGAGGAGGAGGAGGAAGCGGAGAGCTTTGCA
GACATGATGAAGCATGGGCTCACAGAGCTGGATGTGGGCATCACCAAGTTCGTAAGTTCT
CACCAGGGATTCTCAGGAATCTTAAAAGAAAGATACTCTGACTTTGTCGTTCACGAAATA
GGAAGAGATGGACGAATCAGCCATTTGAGTGACTTGTCTGTCCCAGTAGATGAAGAGGAT
CCTTCAGAAGATGTATTTACAGTTTTAACAGCTGAAGAAAAGCAGCGTTTAGAAGAGCTC
CAGCTTTTTAAAAATAAGGAAACCAGTGTTGCCATTGAGGTCATTGAGGACACCAAAGAG
AAAAGAACCATCATCCATCAGGCAATTAAATCTCTGTTTCCAGGATTAGAGACAAAAACA
GAAGACAGAGAAGGGAAGAAATATATAGTAGCCTATCATGCAGCTGGAAAAAAGGCTCTG
GCAAATCCAAGGAAACATTCTTGGCCAAAATCTAGGGGAAGTTACTGTCACTTTGTACTG
TACAAAGAAAACAAAGACACCATGGATGCTATTAATCTGTTGTCCAAATATTTAAGAGTC
AAGCCAAACATATTCTCCTACATGGGAACCAAAGATAAAAGAGCCATAACCGTTCAGGAG
ATTGCTGTTCTCAAAATAACTGCACAAAGACTTGCCCACTTGAACAAGTGCTTGATGAAC
TTTAAGCTGGGGAATTTCAGCTATCAGAAAAACCCTCTGAAATTGGGAGAGCTTCAAGGA
AATCACTTCACAGTTGTCCTCAGAAATATAACAGGAACTGACAACCAAGTGGAACAAGCC
ATGAACTCTCTCAAGGAGATTGGGTTTATCAACTACTATGGAATGCAAAGGTTCGGAACC
ACAGCTGTCCCCACATATCAAGTTGGAAGAGCTATACTGCAAAATTCCTGGGCTGAAGTC
ATGGATTTAATATTGAAACCCCGTTCTGGAGCTGAAAAGGGGTACTTGGTTAAATGCAGG
GAAGAATGGGCGAAGAGCAAAGACCCAGCCGCTGCCCTCCGAAAACTACCTGTCAAAAGG
TGTGTGGAAGGGCAGCTTCTCCGAGGACTTTCAAAATACGGAATGAAGAATATAGTCTCT
GCATTTGGCATAATACCAAGAAATAATCGCTTAATGTACATTCACAGCTATCAGAGCTAC
GTGTGGAACAACATGGTGAGCAAGAGGATTGACGAGTACGGGCTGAAGCCTGTGCCCGGC
GACCTTGTTCTTAAAGGAGCCACAGCCACCTTTATTGAGGAAGATGATGTTAATAATTAC
TCCATCCATGATGTGGTAATGCCTTTGCCTGGTTTTGATGTTATCTACCCCAAGCATAAA
ATTAGTGAAGCCTACAGGGAAATGCTCACAGCAGACAATCTTGATATTGACAACATGAGA
CACAAAATTAGAGATTATTCCTTATCAGGGGCCTACCGAAAGATCATTATTCGTCCTCAG
AATGTCAGCTGGGAAGTTGTTGCGTATGATGATCCTAAAATTCCACTCTTCAACACAGAT
GTGGACAACCTGGAAGGTAGACCACCACCAGTGTTTGCTTCTGAAGGCAAATACAGAGCT
CTGAAGATGGATTTTTCTCTCCCTCCTTCTACCTACGCGACCATGGCCATTCGCGAAGTG
CTTAAAATGGATACCAGCATCAAGAACCAGACCCAGCTGAATACCACCTGGCTCCGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 659 |
| Molecular Weight
| 74594.0 |
| Theoretical pI
| 5.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Pseudouridylate synthase 7 homolog
MEMTEMTSVSLKRGSVAIEDNDSVAPAEEAKRQKVSGCCPTTGQDGIENSSLPSSEKVPG
PPETAEQGEKNSEVPSEEEEEEDGLSEEEEEEEEEAESFADMMKHGLTELDVGITKFVSS
HQGFSGILKERYSDFVVHEIGRDGRISHLSDLSVPVDEEDPSEDVFTVLTAEEKQRLEEL
QLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKAL
ANPRKHSWPKSRGSYCHFVLYKENKDTMDAINLLSKYLRVKPNIFSYMGTKDKRAITVQE
IAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDNQVEQA
MNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWAEVMDLILKPRSGAEKGYLVKCR
EEWAKSKDPAAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSY
VWNNMVSKRIDEYGLKPVPGDLVLKGATATFIEEDDVNNYSIHDVVMPLPGFDVIYPKHK
ISEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTD
VDNLEGRPPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR
|
| External Links |
|---|
| GenBank ID Protein
| AAI23724.1 |
| UniProtKB/Swiss-Prot ID
| Q08DI8 |
| UniProtKB/Swiss-Prot Entry Name
| PUS7_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC123723 |
| GeneCard ID
| PUS7 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
