<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:23:08 UTC</creation_date>
  <update_date>2020-05-20 21:05:43 UTC</update_date>
  <accession>BMDBP00601</accession>
  <secondary_accessions>
    <accession>BMDBP03055</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>ALDH1A1</gene_name>
  <general_function>Energy production and conversion</general_function>
  <specific_function>Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo.</specific_function>
  <pathways>
    <pathway>
      <name>Cofactor metabolism</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Retinol Metabolism</name>
      <smpdb_id>SMP0087260</smpdb_id>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000305</accession>
      <name>Vitamin A</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000990</accession>
      <name>Acetaldehyde</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001358</accession>
      <name>Retinal</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001487</accession>
      <name>NADH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001852</accession>
      <name>Retinoic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002369</accession>
      <name>9-cis-Retinoic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0003141</accession>
      <name>Retinoyl b-glucuronide</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0006219</accession>
      <name>13-cis-Retinoic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000972</accession>
      <name>N10-Formyl-THF</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000217</accession>
      <name>NADP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002111</accession>
      <name>Water</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001846</accession>
      <name>Tetrahydrofolic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001967</accession>
      <name>Carbon dioxide</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000221</accession>
      <name>NADPH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0006218</accession>
      <name>9-cis-Retinal</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>8</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1506 bp
ATGTCGTCCTCAGCCATGCCAGACGTACCTGCCCCACTCACCAATTTGCAGTTTAAATAT
ACTAAGATCTTCATAAACAATGAATGGCATAGTTCAGTGAGTGGTAAGAAATTTCCAGTC
TTTAATCCTGCAACTGAGGAGAAACTCTGTGAGGTGGAAGAAGGAGATAAGGAGGATGTT
GACAAAGCAGTGAAGGCTGTAAGACAAGCTTTTCAGATTGGCTCTCCATGGCGTACTATG
GATGCTTCAGAGAGAGGACGGCTGTTAAACAAGTTGGCTGACTTAATTGAAAGAGATCAT
CTGCTCCTGGCGACAATGGAGGCAATGAATGGTGGAAAACTATTTTCCAATGCATATCTG
ATGGATTTAGGAGGCTGCATAAAAACACTACGCTACTGTGCAGGCTGGGCTGACAAGATC
CAGGGCCGCACAATACCCATGGATGGAAACTTTTTTACATATACAAGAAGTGAGCCTGTT
GGTGTGTGTGGCCAAATCATTCCTTGGAATTTCCCATTGCTCATGTTCCTCTGGAAGATA
GGGCCTGCCCTTAGCTGCGGAAACACAGTGGTTGTCAAACCAGCAGAGCAAACCCCTCTG
ACTGCTCTTCACATGGGATCTTTAATAAAAGAGGCAGGGTTTCCTCCTGGAGTAGTGAAT
ATTGTCCCTGGTTATGGGCCTACTGCAGGGGCAGCCATTTCTTCTCACATGGATGTAGAC
AAAGTGGCCTTCACAGGATCGACAGAGGTTGGCAAACTGATCAAAGAAGCTGCTGGGAAA
AGCAATCTGAAAAGGGTGTCCCTGGAACTCGGGGGAAAGAGTCCTTGCATTGTGTTTGCT
GATGCCGACTTGGACAATGCTGTTGAATTTGCACACCAAGGAGTATTCTATCACCAGGGC
CAGTGTTGTATAGCTGCATCCCGTCTCTTTGTAGAAGAATCAATTTACGATGAGTTTGTT
CGAAGGAGTGTTGAGCGGGCGAAAAAGTATGTTCTTGGAAATCCTCTGACCCCAGGAGTC
AGTCAAGGCCCTCAGATTGATAAAGAACAATATGAAAAAATACTTGACCTCATTGAAAGT
GGGAAGAAGGAGGGGGCCAAGCTGGAATGTGGCGGAGGCCCTTGGGGGAATAAAGGCTAC
TTTATCCAACCCACAGTTTTCTCTGATGTTACTGATGATATGCGCATTGCCAAAGAGGAG
ATATTTGGACCTGTGCAGCAAATCATGAAGTTTAAGTCTTTAGATGATGTAATCAAGAGA
GCAAACAATACTTTCTATGGGTTATCTGCAGGAATATTTACCAATGATATTGATAAAGCC
ATCACAGTCTCCTCTGCTTTGCAGTCTGGAACCGTGTGGGTGAACTGCTATAGTGTGGTA
TCTGCCCAGTGCCCCTTTGGTGGATTCAAGATGTCTGGAAATGGTCGAGAACTGGGAGAA
TATGGTTTCCATGAATACACAGAAGTCAAGACGGTCACAATCAAAATTTCTCAGAAGAAC
TCATAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>501</residue_number>
    <molecular_weight>54806.0</molecular_weight>
    <theoretical_pi>6.62</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Retinal dehydrogenase 1
MSSSAMPDVPAPLTNLQFKYTKIFINNEWHSSVSGKKFPVFNPATEEKLCEVEEGDKEDV
DKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLIERDHLLLATMEAMNGGKLFSNAYL
MDLGGCIKTLRYCAGWADKIQGRTIPMDGNFFTYTRSEPVGVCGQIIPWNFPLLMFLWKI
GPALSCGNTVVVKPAEQTPLTALHMGSLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVD
KVAFTGSTEVGKLIKEAAGKSNLKRVSLELGGKSPCIVFADADLDNAVEFAHQGVFYHQG
QCCIAASRLFVEESIYDEFVRRSVERAKKYVLGNPLTPGVSQGPQIDKEQYEKILDLIES
GKKEGAKLECGGGPWGNKGYFIQPTVFSDVTDDMRIAKEEIFGPVQQIMKFKSLDDVIKR
ANNTFYGLSAGIFTNDIDKAITVSSALQSGTVWVNCYSVVSAQCPFGGFKMSGNGRELGE
YGFHEYTEVKTVTIKISQKNS</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAA74234.1</genbank_protein_id>
  <uniprot_id>P48644</uniprot_id>
  <uniprot_name>AL1A1_BOVIN</uniprot_name>
  <pdb_ids>
    <pdb_id>1BXS</pdb_id>
  </pdb_ids>
  <genbank_gene_id>L36128</genbank_gene_id>
  <genecard_id>ALDH1A1</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
