<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:23:10 UTC</creation_date>
  <update_date>2020-05-20 21:09:29 UTC</update_date>
  <accession>BMDBP00610</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>LTA4H</gene_name>
  <general_function>Amino acid transport and metabolism</general_function>
  <specific_function>Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity (By similarity).</specific_function>
  <pathways>
    <pathway>
      <name>Arachidonic Acid Metabolism</name>
      <smpdb_id>SMP0087220</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Leukotriene B4 biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Lipid metabolism</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0001085</accession>
      <name>Leukotriene B4</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001337</accession>
      <name>Leukotriene A4</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002111</accession>
      <name>Water</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0005087</accession>
      <name>6-trans-Leukotriene B4</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>5</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1836 bp
ATGCCCGAGGTAGTGGATACGTGCTCCTTGGCCTCCCCGGCGTCCGTCTGCCAGACCAAA
CACCTGCACCTGCGTTGCAGCATCGACTTTACTCGCCGGGTACTGAGCGGGACCGCCGCG
CTCACCATCCAGTCCCAGGAGGACAATCTGCGCAGCCTGATTCTGGATACAAAGGACCTC
ACAATAGAAAAAGTGGTCATCAATGGACAAGAAGTCAAATATACTCTTGGAGAAAGACAA
AGTTACAAAGGATCACCAATCGAAATCTCTCTTCCTATTGCTCTATGCAAAAATCAAGAA
ATTGTTATAGAGATTTCTTTCGAGACATCTCCAAAATCTTCTGCTCTTCAGTGGCTCACT
CCTGAACAAACTTCTGGGAAAGAGCACCCCTATCTCTTTAGTCAGTGCCAGGCTATCCAC
TGTAGAGCTATTCTTCCTTGCCAGGACACTCCTTCCGTGAAATTAACCTACAGCGCAGAG
GTGTCTGTCCCCAAAGAACTGGTGGCACTTATGAGTGCCATTCGTGACGGAGAAGCACCT
GACCCAGAAGACCCGAACAGGAAAATTTACAGATTCAGCCAAAAAGTTCCAATCCCCTGC
TACCTGATTGCTTTGGTTGTTGGAGCTTTAGAAAGCAGACAGATTGGCCCAAGGACATTG
GTATGGTCCGAGAAAGAGCAGGTGGAAAAGTCTGCTTACGAATTTTCTGAGACTGAATCT
ATGCTTAAAATTGCAGAAGATCTGGGAGGCCCATATATTTGGGGGCAGTATGACCTATTG
GTCCTGCCGCCATCCTTTCCCTATGGCGGCATGGAGAACCCTTGCCTCACTTTTGTAACT
CCTACTCTGCTGGCTGGTGACAAGTCACTCTCCAATGTTATAGCACATGAAATATCTCAT
AGTTGGACAGGAAATCTAGTGACCAACAAAACTTGGGATCACTTTTGGTTAAATGAAGGA
CATACCGTATACTTGGAACGCCACATTTGTGGACGACTGTTTGGTGAAAAGTTTAGACAT
TTTCACGCTCTGGGCGGATGGGGAGAACTCCAGAATTCGATAAAGACTTTTGGGGAGACC
CATCCTTTCACCAAACTCGTGGTTGACCTGACGAACACAGACCCTGACGTGGCATATTCT
TCAGTTCCCTATGAGAAGGGCTTTGCTTTACTCTTTTACCTTGAACAGCTTCTTGGAGGA
CCAGAGGTTTTCCTAGGATTCTTAAAGGCTTATGTTGAGAAATTTTCCTACAAGAGCATA
ACTACTGATAACTGGAAGGATTTCTTGTATTCCCACTTTAAAGATAAGGTTGATATTCTC
AATCAAGTGGATTGGAACACCTGGCTGTACTCTCCTGGACTGCCCCCTGTAAAACCCAAT
TATGATATGACCCTGACAAATGCTTGCATTTCCTTGAGTCAAAGATGGATCACTGCCAAA
GATGATGATTTAAATTCATTCAGCTCAGCAGACCTAAAAGACTTCTCTTCCCATCAAGTG
AATGAATTTTTAGCACAGATGCTCCAGAATGCACCTCTTCCATTGGGGCACATAAAGCGA
ATGCAAGAGGTGTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGTTA
CGACTCTGCATTCAATCGAAATGGGAGGAAGCAATTCCTTTGGCTCTAAAAATGGCAACT
GAACAAGGAAGGATGAAGTTTACACGGCCCTTATTCAAGGACCTTGCTGCCTTTGACAAA
TCCCATGATCAAGCCATCCGTACCTACAAGGAGCACAAGGCATCCATGCACCCTGTGACT
GCCATGCTTGTGGGGAAAGATTTAAAAGTGGATTAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>611</residue_number>
    <molecular_weight>69306.0</molecular_weight>
    <theoretical_pi>6.33</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Leukotriene A-4 hydrolase
MPEVVDTCSLASPASVCQTKHLHLRCSIDFTRRVLSGTAALTIQSQEDNLRSLILDTKDL
TIEKVVINGQEVKYTLGERQSYKGSPIEISLPIALCKNQEIVIEISFETSPKSSALQWLT
PEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYSAEVSVPKELVALMSAIRDGEAP
DPEDPNRKIYRFSQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETES
MLKIAEDLGGPYIWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISH
SWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNSIKTFGET
HPFTKLVVDLTNTDPDVAYSSVPYEKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYKSI
TTDNWKDFLYSHFKDKVDILNQVDWNTWLYSPGLPPVKPNYDMTLTNACISLSQRWITAK
DDDLNSFSSADLKDFSSHQVNEFLAQMLQNAPLPLGHIKRMQEVYNFNAINNSEIRFRWL
RLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAIRTYKEHKASMHPVT
AMLVGKDLKVD</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI02853.1</genbank_protein_id>
  <uniprot_id>Q3SZH7</uniprot_id>
  <uniprot_name>LKHA4_BOVIN</uniprot_name>
  <pdb_ids>
    <pdb_id>1HS6</pdb_id>
  </pdb_ids>
  <genbank_gene_id>BC102852</genbank_gene_id>
  <genecard_id>LTA4H</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
