| Identification |
|---|
| BMDB Protein ID
| BMDBP00624 |
| Secondary Accession Numbers
| None |
| Name
| 5-aminolevulinate synthase, nonspecific, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ALAS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Not Available |
| Pathways
|
- 5-aminolevulinate from glycine: step 1/1
- Glycine and Serine Metabolism
- Porphyrin Metabolism
- Porphyrin-containing compound metabolism
- Protoporphyrin-IX biosynthesis
|
| Reactions
|
| Glycine + Succinyl-CoA → 5-Aminolevulinic acid + Carbon dioxide |
details
|
| Glycine + Succinyl-CoA → 5-Aminolevulinic acid + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| ALAS1 |
| Gene Sequence
|
>1944 bp
ATGGAGACTGTTGTTCGTCGCTGCCCATTCTTATCCCGAGTGCCTCAAGCCTTTCTGCAG
AAGGCAGGCAAATCTCTATTGTTCTATGCCCAAAACTGCCCTAAGATGATGGAAATTGGG
GCCAAGCCAGCCCCTCGGGCCCTGTCCACTTCAGCAGTACTCTGCCAGCAGGTCACAGAA
ACCCCTCCAGCTAATGAGAAGGACAAAGCCGCCAAAGCCGAAGTGCAGCAGGCTCCTGAT
GGATCCCAGCAGGCTCCTGATGGGTCCCAGCAGACTGCAGATGGCACGCAGCTTCCGTCT
GGACACCCTTCCCTCGCCTCGAGCCAGGGCACTGGGAGCAAATGCCCTTTCCTGGCAGCC
GAGATGAGCCAGGGCGGCAGCAGTGTCTTCCGCAAAGCCAGCCTGGCGCTTCAGGAAGAT
GTGCAGGAGATGCATGCCGTGAGGGAAGAGGTTGCCCAAACTTCAGTGAATCCCAGTGTG
ATTAACGTGAAGACCGAAGGAGGGGAGCTGAATGGACTGTTGAAGAACTTTCAGGATATC
ATGCGAAAGCAGCGACCAGAAAGAGTGTCCCACCTTCTTCAAGATAACTTGCCAAAATCT
GTTTGCACTTTTCAGTATGATCGTTTCTTTGAGAAGAAAATTGATGAGAAAAAAAATGAC
CATAGCTATCGAGTTTTCAAAACTGTGAACCGGAAGGCTCAATGCTTCCCCATGGCAGAT
GACTATTCGGACTCTCTCATCAGCAAAAAGCAGGTGTCTGTCTGGTGTAGCAATGACTAC
CTAGGAATGAGTCGCCACCCACGGGTGTGTGGAGCCGTCATAGACACTTTGAAACAGCAT
GGTACTGGAGCAGGGGGTACTAGAAATATTTCTGGAACTAGTAAATTCCACGTGGACCTG
GAGCAGGAGCTGGCTGACCTCCATGGAAAAGATGCTGCACTCTTGTTCTCCTCGTGCTTT
GTGGCCAATGACTCGACCCTCTTCACTCTGGCTAAGATGATGCCAGGCTGTGAGATTTAC
TCTGACGCTGGGAACCATGCCTCCATGATCCAAGGGATTCGAAACAGTGGAGTGCCAAAG
TACATCTTCCGCCACAACGATGTCAGCCACCTCCGGGAACTGCTGCAGAGGTCTGACCCT
GCCGTCCCCAAGATTGTCGCCTTTGAAACTGTCCACTCAATGGACGGGGCAGTGTGCCCG
CTGGAAGAGCTGTGTGACGTGGCCCACGAGTTTGGAGCAATCACCTTCGTGGATGAGGTC
CACGCAGTGGGGCTCTACGGGCTGCAAGGCGGAGGGATTGGCGATCGGGATGGAGTTATG
CCAAAAATGGACATCATTTCTGGAACACTTGGCAAAGCCATTGGCTGCGTTGGAGGGTAC
ATCGCCAGCACGAGTTCCCTGATCGACACCGTCCGGTCCTACGCAGCGGGCTTCATTTTC
ACCACCTCCCTGCCGCCCATGCTGCTGGCTGGAGCACTGGAGTCTGTGCGGATCCTGAGG
AGCACTGAGGGCCGAACACTTCGCCGCCAACACCAGCGCAACGTGAAGCTCATGAGGCAG
ATGCTGATGGACGCTGGCCTGCCAGTGGTCCACTGCCCCAGTCACATCATCCCCGTCCGG
GTGGCAGATGCTGCTAAAAACACGGAGGTCTGTGATGAACTAATGACTAGACATAATATC
TACGTCCAAGCGATCAATTACCCCACAGTGCCCCGGGGTGAGGAGCTGCTGCGCATCGCC
CCCACGCCCCACCACACACCACAGATGATGAGCTACTTTGTGGATAACCTGCTGGCCACG
TGGAAGCGAGTTGGGCTGGAACTCAAGCCACATTCCTCAGCCGAGTGCAACTTCTGCAGG
AGGCCACTGCATTTTGAAATGATGAGTGAAAGAGAGAAATCCTACTTCTCTGGTATGAGC
AAGCTGGTGTCTGCTCAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 647 |
| Molecular Weight
| 71062.0 |
| Theoretical pI
| 7.92 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>5-aminolevulinate synthase, nonspecific, mitochondrial
METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEIGAKPAPRALSTSAVLCQQVTE
TPPANEKDKAAKAEVQQAPDGSQQAPDGSQQTADGTQLPSGHPSLASSQGTGSKCPFLAA
EMSQGGSSVFRKASLALQEDVQEMHAVREEVAQTSVNPSVINVKTEGGELNGLLKNFQDI
MRKQRPERVSHLLQDNLPKSVCTFQYDRFFEKKIDEKKNDHSYRVFKTVNRKAQCFPMAD
DYSDSLISKKQVSVWCSNDYLGMSRHPRVCGAVIDTLKQHGTGAGGTRNISGTSKFHVDL
EQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDAGNHASMIQGIRNSGVPK
YIFRHNDVSHLRELLQRSDPAVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEV
HAVGLYGLQGGGIGDRDGVMPKMDIISGTLGKAIGCVGGYIASTSSLIDTVRSYAAGFIF
TTSLPPMLLAGALESVRILRSTEGRTLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVR
VADAAKNTEVCDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMSYFVDNLLAT
WKRVGLELKPHSSAECNFCRRPLHFEMMSEREKSYFSGMSKLVSAQA
|
| External Links |
|---|
| GenBank ID Protein
| AAI47979.1 |
| UniProtKB/Swiss-Prot ID
| A6QLI6 |
| UniProtKB/Swiss-Prot Entry Name
| HEM1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC147978 |
| GeneCard ID
| ALAS1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
