| Identification |
|---|
| BMDB Protein ID
| BMDBP00675 |
| Secondary Accession Numbers
| None |
| Name
| Endonuclease III-like protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| NTHL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 25 |
| Locus
| Not Available |
| SNPs
| NTHL1 |
| Gene Sequence
|
>918 bp
ATGAACGCGGCGGGAGTGAGGATGGTGGTGACCCGCGCCCGGAGCCGGGGGACTGGGGCC
AGCCTGAGGCGGCGTGGGGAGAAGGCCGCGCCGCTCCGGAGCGGGGAGGCGGCTGCAGAA
GAGAGGAAAAGCTACAGCCCCGTGAAGCGTCGGCGGAAGGCACAAAGGCTGAGCGTGGCC
TACGAGGCCTCAGAAGGTGAGGGAGGCGAGGGGGCCGAGCATCTCCAGGCACCATCCTGG
CAGCCTCAGGACTGGCGGCAGCAGCTGGACAACATCCGGACCATGAGGAGTGGGAAGGAC
GCACCCGTGGACCAGCTGGGGGCTGAGCACTGCTTTGACCCCAGCGCATCCCCTAAGGTG
CGGAGGTACCAGGTGCTGCTGTCCCTGATGCTCTCCAGCCAGACCAAGGACCAGGTGACA
GCGGGTGCCATGCAGCGCCTACGGGCCCGGGGCCTGACGGTGGACAGCATCCTGCAGACG
GACGACAGCACGCTGGGCGCGCTCATCTATCCTGTGGGCTTCTGGAGGAGCAAGGTAAAG
TACATCAAGCAGACCAGTGCAATCCTGCAGCAGCGTTACGACGGGGACATCCCAGCCTCC
GTGGCAGAGCTGGTGGCGCTGCCCGGCGTCGGGCCCAAGATGGCGCACTTGGCCATGGCG
GTAGCCTGGGGCACCGTGTCAGGCATTGCAGTGGACACACATGTGCACAGAATCGCCAAC
CGACTCAGGTGGACCAAGAAGGCAACTAAGTCCCCAGAGGAAACCCGAAGGGCTCTGGAG
GAGTGGCTGCCCAGGGAACTGTGGAGCGAAATCAACGGCCTGCTGGTGGGCTTCGGCCAG
CAGACTTGCCTGCCCATCCGCCCACGCTGCCAGGCCTGCCTCAACCGGGCCCTGTGCCCA
GCTGCACGGGGACTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 305 |
| Molecular Weight
| 33645.0 |
| Theoretical pI
| 10.75 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Endonuclease III-like protein 1
MNAAGVRMVVTRARSRGTGASLRRRGEKAAPLRSGEAAAEERKSYSPVKRRRKAQRLSVA
YEASEGEGGEGAEHLQAPSWQPQDWRQQLDNIRTMRSGKDAPVDQLGAEHCFDPSASPKV
RRYQVLLSLMLSSQTKDQVTAGAMQRLRARGLTVDSILQTDDSTLGALIYPVGFWRSKVK
YIKQTSAILQQRYDGDIPASVAELVALPGVGPKMAHLAMAVAWGTVSGIAVDTHVHRIAN
RLRWTKKATKSPEETRRALEEWLPRELWSEINGLLVGFGQQTCLPIRPRCQACLNRALCP
AARGL
|
| External Links |
|---|
| GenBank ID Protein
| DAA15605.1 |
| UniProtKB/Swiss-Prot ID
| Q2KID2 |
| UniProtKB/Swiss-Prot Entry Name
| NTH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| GJ062847 |
| GeneCard ID
| NTHL1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
