| Identification |
|---|
| BMDB Protein ID
| BMDBP00677 |
| Secondary Accession Numbers
| |
| Name
| Aldehyde oxidase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| AOX1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis. |
| Pathways
|
Not Available
|
| Reactions
|
| (S)-Methylmalonic acid semialdehyde + Water + Oxygen → Methylmalonic acid + Hydrogen peroxide |
details
|
| 5-Hydroxyindoleacetaldehyde + Oxygen + Water → 5-Hydroxyindoleacetic acid + Hydrogen peroxide |
details
|
| Pyridoxal + Oxygen + Water → 4-Pyridoxic acid + Hydrogen peroxide |
details
|
| 1-Methylnicotinamide + Oxygen + Water → N1-Methyl-2-pyridone-5-carboxamide + Hydrogen peroxide |
details
|
| 1-Methylnicotinamide + Water + Oxygen → N1-Methyl-4-pyridone-3-carboxamide + Hydrogen peroxide |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| AOX1 |
| Gene Sequence
|
>4020 bp
ATGGAAGGGGGCTCCGAGCTGCTCTTCTACGTGAACGGCCGCAAGGTGACAGAAAAAAAT
GTTGATCCTGAAACAATGCTATTGCCATATCTGAGGAAAAAGCTCCGACTCACAGGAACT
AAATATGGCTGTGGAGGGGGAGGCTGTGGTGCCTGCACAGTGATGATATCACGATATAAC
CCCATTACCAAGAAGATAAGACATTATCCAGCCAACGCCTGTCTGACGCCCATCTGTTCT
CTGTATGGGGCTGCCGTCACCACAGTAGAAGGCATAGGAAGCACCAAGACCAGGATTCAT
CCTGTTCAGGAGAGGATTGCCAAGTGTCACGGCACGCAGTGTGGCTTCTGCACCCCCGGG
ATGGTGATGTCCCTGTACACGCTGCTGAGGAACCATCCGGAGCCCACCCTGACTCAGCTA
AATGATGCTCTTGGTGGTAACCTGTGTCGTTGCACTGGATACAGGCCCATAATCAATGCA
TGCAAGACTTTCTGTAAAACTTCTGGCTGCTGTCAAAGTAAAGAAAATGGGGTTTGCTGT
TTGGATCAAGGAATGAATGGATTACCAGAATTTGAGGAAGGAAATGAGACAAGTCTGAAA
CTCTTCTCAGAAGAGGAGTTTCTGCCATTGGATCCAACTCAAGAGCTGATATTTCCTCCC
GAGCTAATGACAATGGCTGAGAAAAAAACACAGAAGACCAGGATTTTTGGTAGTGATAGA
ATGACCTGGATTTCCCCAGTGACCCTGAAGGAACTTCTAGAAGCCAAAGTCAAGTATCCC
CAGGCCCCTGTTGTCATGGGGAACACCTCTGTGGGCCCTGACATGAAATTTAAAGGCATC
TTTCACCCAGTTATAATTTCTCCTGATAGAATTGAAGAACTGAGTGTTGTAAACTATACA
GATAACGGGCTGACCTTAGGTGCTGCTGTCAGCCTCGCTGAGGTGAAAGACATCCTGGCT
AATGTGACCCGGAAACTCCCTGAGGAGAAGACACAGATGTACCATGCTCTCCTGAAACAT
TTGGAAACTCTGGCTGGGCCGCAGATCAGGAATATGGCTTCTTTAGGGGGCCACATAGTG
AGCAGGCATCCAGATTCAGATCTGAACCCTCTCCTGGCTGTGGGCAACTGTACCCTCAAC
CTGCTGTCAAAAGAAGGAAGACGACAGATTCCTTTAAATGAGCAGTTTCTCAGAAAGTGC
CCAAGTGCCGATCTTAAGCCTGAAGAAATCTTGATCTCAGTGAACATCCCCTATTCAAGG
AAGTGGGAGTTTGTGTCAGCCTTCCGACAAGCCCAGCGGCAACAGAATGCGCTTGCAATA
GTTAATTCGGGAATGAGAGTGTGTTTTGGAAAAGGAGATGGCATCATCAGAGAGTTATCC
ATTGCATACGGAGGCGTTGGTCCAACCACCATCCTTGCAAATAATTCCTGCCAGAAACTC
ATTGGAAGGCCCTGGAATGAAGAGATGCTGGATGCAGCTTGCAGGCTGATTCTGGATGAA
GTCTCCCTCCCAGGCTCAGCCCCAGGTGGGAGGGTGGAGTTCAAGAGGACCCTCATTGTC
AGCTTCCTGTTCAAGTTCTACCTGGAAGTGTCACAGATTTTGAAGGGGATGGACCTTGTT
CACTATCCTAGCCTTGCAAGCAAATATGAGAGTGCTTTAGAAGATCTTCATTCCAGACAT
TACTGGAGTACATTAAAGTACCAGAATGCAGACCTAAAGCAGCTTTCTCAAGACCCAATT
GGCCATCCCATCATGCACCTGTCTGGTATTAAGCATGCCACGGGCGAAGCCATCTACTGT
GACGACATGCCTGTGGTGGACCGGGAACTGTTCTTGACTTTTGTAACAAGTTCAAGAGCT
CATGCTAAGATTGTGTCTATCGATGTCTCTGCAGCTCTCAGCCTGCCTGGGGTGGTAGAC
ATCCTGACTGGGGAACATCTTCCAGGCATCAACACCACCTTTGGCTTTTTAACTGACGCT
GATCAACTTCTGTCAACAGATGAGGTGTCTTGTGTGGGTCAGCTTGTCTGCGCCGTGATA
GCCGATTCCGAGGTCCAGGCAAGGCGAGCTGCTCAGCAAGTGAAGATTGTCTACCAAGAT
TTGGAGCCAGTGATCCTAACCATTGAGGAAGCTATACAAAACAAGTCCTTCTTTGAGCCA
GAGAGGAAACTGGAGTATGGAAATGTGGATGAAGCATTTAAAATGGTGGATCAAATTCTT
GAAGGTGAAATACACATGGGAGGTCAAGAACACTTTTATATGGAAACCCAGAGCATGCTG
GTTGTTCCCAAAGGAGAAGATCGAGAAATCGATGTCTACGTGTCTGCTCAGTTTCCTAAA
TACATACAGGACATAACTGCTTCAGTCTTGAAGGTCTCAGCTAACAAAGTCATGTGTCAC
GTAAAGCGTGTTGGTGGAGCCTTTGGGGGAAAGGTGACAAAAACTGGCGTCCTGGCAGCC
ATCACCGCATTTGCTGCAAACAAGCATGGTCGTCCAGTCCGCTGCATTCTGGAACGAGGA
GAAGACATATTAATAACTGGAGGCCGCCACCCTTACCTTGGAAAGTATAAAGCTGGATTC
ATGAATGATGGCAGAATCTTGGCCCTGGATATGGAGCATTATAACAATGCAGGTGCCTTC
CTGGATGAGTCATTATTTGTAATAGAGATGGGACTTCTGAAACTGGAAAATGCCTACAAG
TTTCCCAACCTGCGCTGCCGGGGGTGGGCGTGCAGAACCAACCTTCCATCCAACACAGCT
TTGCGAGGGTTTGGCTTTCCCCAGGCAGGGCTGATCACCGAAGCCTGTATCACAGAAGTG
GCAGCCAAATGTGGGTTGCCCCCTGAGAAGGTCCGAATGATAAACATGTATAAGGAAATT
GATCAAACACCCTACAAACAGGAGATTAATACCAAGAACCTGACCCAGTGTTGGAAAGAA
TGCATGGCCACGTCTTCCTACACCCTAAGGAAAGCAGCGGTGGAGAAATTCAACTCGGAG
AATTACTGGAAGAAGAAGGGGCTGGCAATGGTCCCCCTGAAGTATCCTATTGGCCTTGGA
TCAGTTGCTGCTGGTCAGGCTGCTGCCCTGGTTCACATTTATCTGGATGGGTCTGTGCTG
GTGACTCACGGTGGAATTGAAATGGGGCAGGGGGTCCACACTAAAATGATTCAGGTGGTG
AGTCGTGAGTTAAGGATGCCACTGTCCAGTATCCACCTCCGGGGAACAAGCACAGAAACC
ATCCCTAATACAAATCCCTCTGGAGGTTCCGTAGTGGCTGATCTCAACGGGTTGGCAGTA
AAGGATGCTTGTCAGACTCTTCTGAAACGCCTTAAACCCATCATCAGCAAGAATCCCAAA
GGCACTTGGAAAGATTGGGCACAGGCTGCCTTTAATGAAAGCATTAGTCTCTCAGCTACT
GGATACTTCAGGGGTTATGAGTCGAACATAAACTGGGAGACAGGCGAAGGCCACCCTTTC
GAATACTTTGTTTATGGAGCAGCCTGTTCCGAGGTTGAGATAGACTGCCTGACAGGTGCT
CATAAGAACATCAGAACAGACATTGTCATGGATGTTGGCTACAGTATAAATCCAGCCCTT
GACGTAGGCCAGATTGAAGGTGCATTTATTCAAGGCATGGGACTTTATACAATAGAGGAA
CTGAATTATTCTCCTCAAGGTGTCCTGTACACCCGGGGCCCGAACCAGTATAAAATCCCT
GCCATCTGTGACATCCCCATGGAGCTGCACATTTCTTTTTTGCCTCCCTCTGAAAACTCG
AATACCCTGTATTCGTCTAAGGGTCTGGGAGAGTCTGGGATATTCCTGGGGTGCTCAGTG
TTTTTCGCCATCCACGATGCAATAAGGGCAGCACGACAGGAGAGAGGCCTGCCTGGACCA
CTGAGGCTCAACAGCCCACTGACTCCAGAGAAGATTAGAATGGCCTGTGAAGACAAGTTC
ACAAAAATGATTCCAAGAGATGAACCTGGATCGTATGTTCCTTGGAGTGTACCCATATGA
|
| Protein Properties |
|---|
| Number of Residues
| 1339 |
| Molecular Weight
| 147611.0 |
| Theoretical pI
| 7.29 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aldehyde oxidase
MEGGSELLFYVNGRKVTEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYN
PITKKIRHYPANACLTPICSLYGAAVTTVEGIGSTKTRIHPVQERIAKCHGTQCGFCTPG
MVMSLYTLLRNHPEPTLTQLNDALGGNLCRCTGYRPIINACKTFCKTSGCCQSKENGVCC
LDQGMNGLPEFEEGNETSLKLFSEEEFLPLDPTQELIFPPELMTMAEKKTQKTRIFGSDR
MTWISPVTLKELLEAKVKYPQAPVVMGNTSVGPDMKFKGIFHPVIISPDRIEELSVVNYT
DNGLTLGAAVSLAEVKDILANVTRKLPEEKTQMYHALLKHLETLAGPQIRNMASLGGHIV
SRHPDSDLNPLLAVGNCTLNLLSKEGRRQIPLNEQFLRKCPSADLKPEEILISVNIPYSR
KWEFVSAFRQAQRQQNALAIVNSGMRVCFGKGDGIIRELSIAYGGVGPTTILANNSCQKL
IGRPWNEEMLDAACRLILDEVSLPGSAPGGRVEFKRTLIVSFLFKFYLEVSQILKGMDLV
HYPSLASKYESALEDLHSRHYWSTLKYQNADLKQLSQDPIGHPIMHLSGIKHATGEAIYC
DDMPVVDRELFLTFVTSSRAHAKIVSIDVSAALSLPGVVDILTGEHLPGINTTFGFLTDA
DQLLSTDEVSCVGQLVCAVIADSEVQARRAAQQVKIVYQDLEPVILTIEEAIQNKSFFEP
ERKLEYGNVDEAFKMVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDREIDVYVSAQFPK
YIQDITASVLKVSANKVMCHVKRVGGAFGGKVTKTGVLAAITAFAANKHGRPVRCILERG
EDILITGGRHPYLGKYKAGFMNDGRILALDMEHYNNAGAFLDESLFVIEMGLLKLENAYK
FPNLRCRGWACRTNLPSNTALRGFGFPQAGLITEACITEVAAKCGLPPEKVRMINMYKEI
DQTPYKQEINTKNLTQCWKECMATSSYTLRKAAVEKFNSENYWKKKGLAMVPLKYPIGLG
SVAAGQAAALVHIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPLSSIHLRGTSTET
IPNTNPSGGSVVADLNGLAVKDACQTLLKRLKPIISKNPKGTWKDWAQAAFNESISLSAT
GYFRGYESNINWETGEGHPFEYFVYGAACSEVEIDCLTGAHKNIRTDIVMDVGYSINPAL
DVGQIEGAFIQGMGLYTIEELNYSPQGVLYTRGPNQYKIPAICDIPMELHISFLPPSENS
NTLYSSKGLGESGIFLGCSVFFAIHDAIRAARQERGLPGPLRLNSPLTPEKIRMACEDKF
TKMIPRDEPGSYVPWSVPI
|
| External Links |
|---|
| GenBank ID Protein
| CAA60701.1 |
| UniProtKB/Swiss-Prot ID
| P48034 |
| UniProtKB/Swiss-Prot Entry Name
| AOXA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| X87251 |
| GeneCard ID
| AOX1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
