1.0 2018-05-07 22:23:30 UTC 2020-05-20 21:06:57 UTC BMDBP00681 Enzyme ACO1 Energy production and conversion Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding. Warburg Effect SMP0087270 BMDB0000094 Citric acid BMDB0000193 Isocitric acid BMDB0000692 Iron BMDB0001149 5-Aminolevulinic acid 8 >2670 bp ATGAGCAACCCATTTGCACACCTTGTTGAGCCTTTGGATCCTGCACAACCAGGAAAGAAG TTCTTCAATTTGAATAAATTGGAGGATTCCAGATATGGATCCTTACCATTTTCTATCAGA GTTCTCCTGGAGGCAGCCATTCGGAACTGTGATCAATTTTTGGTGAAGAAAAATGATGTT GAAAATATCCTGAATTGGAAGGTCATGCAGCATAAGAACATAGAAGTGCCCTTTAAGCCT GCCCGAGTCATCCTGCAGGACTTTACGGGTGTGCCAGCTGTGGTTGACTTTGCTGCCATG CGTGATGCTGTGAAAAAGTTAGGAGGCAATCCAGAGAAAATAAACCCCATCTGTCCTGCT GATCTTGTCATTGATCATTCCATCCAGGTTGATTTCAACAGAAGGGCAGACAGTTTAAAG AAGAATCAAGACTTGGAATTTGAAAGAAATAAAGAACGATTTGAATTTTTAAAGTGGGGC TCTCAGGCCTTTCACAACATGAGGATTATTCCACCGGGCTCAGGAATCATCCACCAGGTG AATCTGGAGTATTTGGCAAGAGTGGTCTTTGATCAGGATGGATATTACTACCCAGACAGC CTTGTGGGCACAGATTCGCACACCACCATGATTGATGGTTTGGGTGTCCTTGGTTGGGGT GTGGGTGGTATCGAAGCAGAAGCTGTGATGCTGGGCCAGCCAATCAGCATGGTGCTTCCC CAGGTGATCGGCTACAGGCTGGTGGGAAATCCCCACCCCCTGGTCACATCCACTGACATC GTGCTCACCATCACCAAGCACCTCCGCCAGGTTGGGGTAGTAGGCAAGTTTGTCGAGTTC TTTGGGCCAGGAGTAGCCCAACTGTCCATTGCCGACCGAGCTACAATTGCCAACATGTGT CCAGAGTATGGGGCCACTGCCGCCTTTTTCCCAGTTGATGAAGTTAGTATCAAGTACCTG GTGCAGACAGGTCGTGACAAAGAAAAAGTAAAGCATATTAAACAGTATCTTCAGGCTGTA GGAATGTTTCGGGACTTCAGTGACTCCTCTCAAGACCCAGACTTTGCCCAGGTTGTGGAA TTAGACTTGAAAACAGTAGTGCCTTGCTGCAGCGGACCCAAAAGGCCTCAGGACAAAGTT GCCGTGTCTGATATGAAAAAGGACTTTGAGAGCTGCCTGGGGGCCAAGCAAGGATTTAAA GGATTCCAGGTTGCTCCAGACCATCATAATGACCATAAGACATTTATCTATAATAACAGC AAGTTCACCCTTGCTCATGGTTCTGTGGTAATCGCTGCCATTACTAGCTGCACAAACACC AGTAATCCATCTGTGATGTTAGGGGCAGGCTTGTTAGCGAAGAAGGCTGTGGATGCAGGC CTGAGCGTGAAGCCTTACATCAAAACTAGCCTGTCTCCTGGCAGTGGTGTGGTCACCTAC TACCTGCGGGAAAGCGGAGTCATGCCTTACCTGTCTCAGCTTGGGTTTGACGTGGTGGGC TATGGCTGCATGACCTGCATCGGCAACAGCGGGCCCTTACCGGAAGCTGTGGTAGAAGCC ATCGTACAGGGGGACCTCGTAGCTGTTGGAGTACTGTCTGGGAACAGGAACTTTGAAGGG CGAGTCCACCCCAATACCCGGGCCAACTATTTAGCCTCTCCGCCCTTAGTAATAGCCTAT GCGATTGCTGGGACCATCAGGATCGACTTTGAGAAAGAGCCACTAGGTGTCAATGCCAAG GGACAGCAAGTATTTCTGAAAGATATCTGGCCGACCAGAGATGAGATCCAGGCAGTGGAA CGTCAGTACGTGATCCCTGGGATGTTTAAGGAGGTCTACCAGAAAATAGAGACTGTGAAT GAGAGCTGGAATGCCTTAGCAGCCCCGTCAGATAAGCTATATTGCTGGAATCCCAAATCT ACATACATTAAATCACCACCATTCTTTGAAGACCTGACTTTGGATCTTCAGCCCCCTAAG TCTATTGTGGATGCCTATGTGCTATTAAACTTGGGAGATTCAGTAACAACAGACCACATC TCTCCAGCTGGAAACATCGCAAGAAACAGCCCTGCTGCTCGCTACTTAACTAACAGAGGC CTGACTCCTCGAGAATTCAACTCCTACGGCTCCCGCCGAGGGAATGATGCCATCATGGCA CGGGGGACATTTGCCAACATCCGCTTATTAAACAAATTCTTGAACAAGCAGGCACCGCAG ACTATCCACCTGCCTTCTGGTGAAATTCTTGACGTGTTCGACGCCGCTGAGCGGTACCAG CAGGCGGGCCTCCCCCTCATCGTCCTGGCGGGCAAAGAGTACGGCTCGGGCAGCTCCCGA GACTGGGCCGCCAAGGGCCCTTTCCTCCTGGGAATCAGAGCTGTCCTAGCAGAGAGTTAC GAGCGCATTCACCGAAGTAACTTGGTCGGGATGGGGGTGATCCCTCTCGAGTACCTCCCT GGGGAGAATGCAGACACCCTGGGACTCACTGGGCGTGAACGATACACTATTAGCATTCCA GAAACCCTGAAACCACGAATGAAAGTCCAGATCAAGCTGGATACCGGGAAGACCTTCCAG GCTGTCATGAGGTTTGACACCGACGTGGAGCTCACTTATTTCCATAACGGGGGCATCCTC AACTACATGATCCGCAAGATGACCAAGTAG 889 98204.0 8.09 None >Cytoplasmic aconitate hydratase MSNPFAHLVEPLDPAQPGKKFFNLNKLEDSRYGSLPFSIRVLLEAAIRNCDQFLVKKNDV ENILNWKVMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPICPA DLVIDHSIQVDFNRRADSLKKNQDLEFERNKERFEFLKWGSQAFHNMRIIPPGSGIIHQV NLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLP QVIGYRLVGNPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMC PEYGATAAFFPVDEVSIKYLVQTGRDKEKVKHIKQYLQAVGMFRDFSDSSQDPDFAQVVE LDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNNS KFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLSVKPYIKTSLSPGSGVVTY YLRESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEAVVEAIVQGDLVAVGVLSGNRNFEG RVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVE RQYVIPGMFKEVYQKIETVNESWNALAAPSDKLYCWNPKSTYIKSPPFFEDLTLDLQPPK SIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAIMA RGTFANIRLLNKFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGSGSSR DWAAKGPFLLGIRAVLAESYERIHRSNLVGMGVIPLEYLPGENADTLGLTGRERYTISIP ETLKPRMKVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKMTK AAI20007.1 Q0VCU1 ACOC_BOVIN BC120006 ACO1