| Identification |
|---|
| BMDB Protein ID
| BMDBP00687 |
| Secondary Accession Numbers
| |
| Name
| Aconitate hydratase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACO2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. |
| Pathways
|
- Carbohydrate metabolism
- Isocitrate from oxaloacetate: step 2/2
- Tricarboxylic acid cycle
|
| Reactions
|
| Citric acid → cis-Aconitic acid + Water |
details
|
| cis-Aconitic acid + Water → Isocitric acid |
details
|
| Citric acid → Isocitric acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q35 |
| SNPs
| ACO2 |
| Gene Sequence
|
>2343 bp
ATGGCGCCTTACAGCCTACTGGTGTCCCGGCTGCAGAAAGCCCTGGGTGCGCGGCAGTAC
CATGTGGCCTCAGTCCTGTGCCAACGGGCCAAGGTGGCCATGAGCCACTTTGAACCCAAT
GAGTACATCCGCTATGACCTGCTCGAGAAGAACATTAACATTGTCCGCAAACGGCTGAAC
CGGCCTCTGACCCTCTCAGAGAAGATCGTGTATGGACACCTGGATGACCCGGCCAACCAG
GAGATCGAGCGGGGCAAGACATACCTGCGGCTGCGGCCTGACCGCGTGGCCATGCGGGAT
GCCACGGCCCAGATGGCCATGCTGCAGTTCATCAGCAGCGGCCTGCCCAAGGTGGCCGTG
CCGTCCACCATCCACTGTGACCATTTGATCGAGGCCCAGCTCGGCGGGGAGAAGGACCTG
CGTCGGGCCAAGGACATAAACCAGGAAGTGTATAATTTCCTGGCCACTGCAGGTGCCAAG
TACGGCGTGGGCTTCTGGAGGCCTGGCTCTGGAATCATTCACCAGATCATTCTGGAAAAC
TATGCGTACCCTGGGGTTCTTCTGATTGGCACTGATTCCCACACCCCTAATGGCGGTGGC
CTGGGAGGCATCTGCATTGGAGTCGGGGGTGCTGATGCCGTGGACGTCACGGCTGGGATC
CCCTGGGAGTTGAAGTGCCCCAAGGTGATTGGCGTGAAGCTGACAGGCTCCCTCTCTGGC
TGGACCTCACCTAAAGATGTGATCCTGAAGGTGGCGGGTATCCTCACAGTGAAAGGTGGC
ACGGGCGCCATCGTGGAGTACCACGGGCCTGGAGTAGACTCCATCTCCTGCACCGGCATG
GCGACCATCTGCAACATGGGTGCAGAAATCGGGGCCACCACTTCGGTGTTCCCTTACAAC
CACAGGATGAAGAAATACCTGAGCAAGACAGGCCGGGCAGATATTGCCAACCTTGCTGAT
GAATTCAAGGATCACTTGGTACCTGACTCTGGCTGCCATTATGACCAACTGATTGAAATT
AACCTCAGTGAGCTGAAGCCGCACATCAATGGGCCCTTTACCCCTGACCTGGCTCACCCT
GTGGCAGAAGTGGGCAGTGTGGCAGAGAAGGAGGGGTGGCCCTTGGACATCCGAGTTGGT
CTGATTGGCAGCTGTACCAACTCCAGCTATGAAGACATGGGCCGCTCCGCAGCCGTGGCC
AAGCAGGCGCTGGCCCACGGACTCCAGTGCAAATCCCAGTTCACCATCACCCCAGGCTCG
GAGCAGATCCGCGCCACCATCGAGCGGGATGGCTATGCACAGATCCTGAGGGATGTGGGT
GGCATCGTCCTGGCCAATGCCTGCGGGCCCTGCATTGGCCAATGGGACAGGAAGGACATC
AAGAAGGGGGAGAAGAACACCATCGTCACCTCCTACAACAGGAACTTCACAGGCCGCAAC
GACGCAAATCCTGAGACCCACGCCTTCGTCACGTCCCCAGAGATTGTCACAGCCCTGGCC
ATTGCTGGCACCCTCAAGTTCAACCCAGAGACTGACTTCCTGACGGGCAAGGACGGCAAG
AAGTTCAAGCTGGAGGCTCCAGACGCAGATGAGCTTCCTCGAGCGGAGTTCGACCCCGGA
CAGGACACCTACCAGCACCCCCCCAAGGACAGCAGTGGGCAGCAGGTGGACGTGAGTCCC
ACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTCGACAAGTGGGACGGCCGAGACCTGGAG
GACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACCGACCACATCTCGGCTGCT
GGTCCCTGGCTCAAGTTCCGTGGGCACCTGGACAACATCTCCAACAACCTGCTCATTGGC
GCCATCAACGTGGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACCCAGGAGTTC
GGTCCTGTCCCTGACACCGCCCGCTACTACAAGAAACACGGCATCCGGTGGGTGGTGATT
GGAGATGAAAACTATGGTGAGGGCTCGAGCCGGGAGCACGCAGCCCTGGAGCCTCGCCAC
CTCGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAAACCAACCTGAAG
AAGCAGGGCCTGCTGCCCCTCACCTTCGCTGACCCAGCTGACTACAACAAGATTCACCCT
GTGGACAAGCTGACCATCAAGGGCCTGAAGGACTTTGCCCCCGGCAAGCCGCTGACATGT
ATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAG
ACCCAGATCGAGTGGTTCCGCGCCGGCAGCGCGCTCAACAGGATGAAGGAGCTGCAGAAG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 780 |
| Molecular Weight
| 85359.0 |
| Theoretical pI
| 7.9 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Aconitate hydratase, mitochondrial
MAPYSLLVSRLQKALGARQYHVASVLCQRAKVAMSHFEPNEYIRYDLLEKNINIVRKRLN
RPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAV
PSTIHCDHLIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILEN
YAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSG
WTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYN
HRMKKYLSKTGRADIANLADEFKDHLVPDSGCHYDQLIEINLSELKPHINGPFTPDLAHP
VAEVGSVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLQCKSQFTITPGS
EQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRN
DANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRAEFDPG
QDTYQHPPKDSSGQQVDVSPTSQRLQLLEPFDKWDGRDLEDLQILIKVKGKCTTDHISAA
GPWLKFRGHLDNISNNLLIGAINVENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVI
GDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPADYNKIHP
VDKLTIKGLKDFAPGKPLTCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQK
|
| External Links |
|---|
| GenBank ID Protein
| CAA90177.1 |
| UniProtKB/Swiss-Prot ID
| P20004 |
| UniProtKB/Swiss-Prot Entry Name
| ACON_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| Z49931 |
| GeneCard ID
| ACO2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
