1.0 2018-05-07 22:23:40 UTC 2020-05-20 21:11:57 UTC BMDBP00714 Enzyme LRAT Involved in phosphatidylcholine-retinol O-acyltransfera Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters (PubMed:9920938, PubMed:2722792). Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology (By similarity). Cofactor metabolism Retinol Metabolism SMP0087260 BMDB0000305 Vitamin A 17 >693 bp ATGAAGAACCCAATGCTGGAGGCCGTGTCGCTCGTGCTGGAGAAGCTACTCTTCATCTCC TACTTCAAGTTCTTCAGTTCAGGCGCCCCGGGGCAAGACAAGGCGGGGAACACTTTATAT GAGATCAGCTCTTTTCTCCGCGGTGACGTGCTGGAGGTGCCTCGGACCCACCTGACGCAC TATGGCATCTACCTGGGCGACAACCGTGTTGCCCACATGATGCCCGATATCCTGTTGGCC CTGACTGACGACAAAGGGCGCACGCAGAAAGTGGTCTCCAACAAGCGTCTCATCCTAGGC GTCATTGGCAGGGTGGCCAGCATCCGCGTGGACACCGTGGAGGACTTCGCCTACGGAGCC GAGATCCTGGTGAATCACCTGGACAGGTCCCTCAAGAAGAAGGCACTGCTCAACGAGGAG GTGGCGCAGAGGGCAGAGAAGCTGCTGGGCATAACTCCCTACAGCCTACTTTGGAACAAC TGCGAGCATTTCGTCACCTACTGCAGATATGGCACCCCGATTAGTCCCCAGGCCGACAAG TTTTGTGAGAATGTGAAGATAATTATTCGTGATCAGAGAAGCGTCCTTGCTTCTGCAGTC TTGGGATTGGCGTCTATATTCTGTCTGGGCTTGACATCATATACCACTCTTCCTGCAATT TTTATTCCATTCTTATTATGGATGGCTGGCTAA 230 25701.0 8.59 195-215 None >Lecithin retinol acyltransferase MKNPMLEAVSLVLEKLLFISYFKFFSSGAPGQDKAGNTLYEISSFLRGDVLEVPRTHLTH YGIYLGDNRVAHMMPDILLALTDDKGRTQKVVSNKRLILGVIGRVASIRVDTVEDFAYGA EILVNHLDRSLKKKALLNEEVAQRAEKLLGITPYSLLWNNCEHFVTYCRYGTPISPQADK FCENVKIIIRDQRSVLASAVLGLASIFCLGLTSYTTLPAIFIPFLLWMAG AAK08701.1 Q9BGL2 LRAT_BOVIN AF275344 LRAT