| Identification |
|---|
| BMDB Protein ID
| BMDBP00715 |
| Secondary Accession Numbers
| None |
| Name
| Retinol dehydrogenase 5 |
| Synonyms
|
Not Available
|
| Gene Name
| RDH5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner (PubMed:7544779, PubMed:7836368, PubMed:9654122). Has no activity towards all-trans retinal (PubMed:9654122). Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE) (By similarity). Also recognizes steroids (androsterone, androstanediol) as its substrates (By similarity). |
| Pathways
|
- Cofactor metabolism
- Retinol Metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| RDH5 |
| Gene Sequence
|
>957 bp
ATGTGGCTGCCTCTGCTGCTGGGTGTCTTGCTCTGGGCAGCACTGTGGTTGCTCAGGGAC
CGGCAGTGCCTGCCAGCCAGCGATGCCTTTATCTTCATCACCGGCTGTGACTCGGGCTTT
GGGCGGCTCCTTGCTCTGAGGCTGGACCAGAGAGGCTTCCGAGTACTGGCCAGCTGCCTG
ACACCCTCGGGGGCGGAGGACCTCCAGCGGGTCGCCTCCTCCCGCCTCCACACCACCCTG
CTGGATGTCACAGATCCCCAGAGCATCCGGCAGGCAGTCAAGTGGGTGGAAACGCATGTT
GGGGAAGCAGGGCTTTTTGGTCTGGTGAATAATGCTGGTGTGGCTGGCATCATTGGTCCC
ACCCCATGGCAGACGCGGGAGGACTTCCAGCGGGTGCTGAATGTGAACACGCTGGGTCCC
ATCGGGGTCACCCTCGCCCTGCTGCCCCTGCTGCTGCAGGCCCGGGGCCGAGTGATCAAC
ATCACCAGTGTCCTTGGCCGTCTGGCAGCCAATGGAGGGGGCTACTGCGTCTCCAAGTTT
GGCCTGGAGGCCTTCTCTGACAGCCTGAGGCGAGATGTGGCTCCTTTTGGGGTACGGGTC
TCTATCGTGGAACCTGGCTTCTTCCGAACCCCTGTGACAAACCTGGAAACTTTGGAGGAC
ACCCTGCAGGCCTGCTGGGCACGGCTGCCTCCAGCCACACAGGCCCTCTATGGGGAGGCC
TTCCTCACCAAATACCTGAGAGTGCAGCAACGTATCATGAACATGATCTGTGATCCGGAC
CTGGCCAAGGTGAGCAGGTGCCTGGAGCATGCCCTAACTGCCCGTCACCCCAGAACCCGC
TACAGCCCAGGCTGGGATGCCAAGCTGCTCTGGTTGCCAGCCTCCTACTTGCCAGCCAGG
CTGGTGGATGCTGTGCTCGCCTGGGTCCTTCCCAAGCCTGCCCAGACAGTCTACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 318 |
| Molecular Weight
| 35037.0 |
| Theoretical pI
| 9.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>11-cis retinol dehydrogenase
MWLPLLLGVLLWAALWLLRDRQCLPASDAFIFITGCDSGFGRLLALRLDQRGFRVLASCL
TPSGAEDLQRVASSRLHTTLLDVTDPQSIRQAVKWVETHVGEAGLFGLVNNAGVAGIIGP
TPWQTREDFQRVLNVNTLGPIGVTLALLPLLLQARGRVINITSVLGRLAANGGGYCVSKF
GLEAFSDSLRRDVAPFGVRVSIVEPGFFRTPVTNLETLEDTLQACWARLPPATQALYGEA
FLTKYLRVQQRIMNMICDPDLAKVSRCLEHALTARHPRTRYSPGWDAKLLWLPASYLPAR
LVDAVLAWVLPKPAQTVY
|
| External Links |
|---|
| GenBank ID Protein
| AAA80694.1 |
| UniProtKB/Swiss-Prot ID
| Q27979 |
| UniProtKB/Swiss-Prot Entry Name
| RDH5_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L36533 |
| GeneCard ID
| RDH5 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
