1.0 2018-05-07 22:23:59 UTC 2020-05-20 21:10:23 UTC BMDBP00784 BMDBP03056 Enzyme SORD Amino acid transport and metabolism Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). BMDB0000902 NAD BMDB0001266 L-Sorbose BMDB0001303 Zinc BMDB0001487 NADH BMDB0011632 L-Iditol BMDB0000247 Sorbitol BMDB0000660 D-Fructose 10 >1071 bp ATGGCGGCGGCCAAGCCCGAGAACCTCTCCCTGGTGGTGCACGGACCCGGAGACTTGCGC TTGGAAAACTATCCTATCCCTGAACCAGGCCCAAATGAGGTGCTTCTGAAGATGCATTCT GTTGGAATTTGTGGCTCAGATGTCCATTACTGGCAGCATGGTCGAATTGGAGATTTTGTT GTGAAAAAGCCAATGGTGCTGGGGCATGAAGCTTCAGGAACAGTCGTAAAAGTGGGATCA TTGGTCAGGCACCTACAACCAGGTGATCGTGTCGCCATCGAGCCTGGTGCTCCTCGAGAA ACTGATGAGTTCTGCAAGATTGGCCGATACAATCTGTCACCTACCATCTTCTTCTGCGCC ACGCCCCCTGATGATGGGAACCTCTGCCGGTTCTACAAGCACAATGCTAACTTCTGCTAC AAGCTTCCTGACAATGTCACCTTTGAGGAAGGGGCCCTGATTGAGCCACTGTCTGTGGGG ATCCATGCCTGCCGGCGAGCTGGAGTCACGCTGGGGAACAAGGTCCTTGTGTGTGGAGCT GGGCCAATTGGACTGGTCAGTTTGCTTGCAGCCAAGGCAATGGGTGCAGCTCAAGTGGTG GTGACTGATCTGTCAGCCTCTCGGTTGTCTAAAGCCAAGGAAGTCGGGGCTGATTTCATC CTCCAGATCTCCAACGAGAGCCCTCAGGAAATAGCCAAGAAAGTGGAAGGCCTGCTGGGC AGCAAGCCAGAAGTCACAATTGAGTGCACAGGGGTGGAGACCTCCATCCAAGCCGGCATC TACGCCACTCATTCTGGTGGGACCCTGGTGTTGGTGGGGCTGGGCTCTGAGATGACCAGC GTGCCCCTCGTGCACGCAGCCACCAGGGAGGTGGACATCAAGGGCGTGTTTCGATACTGC AATACATGGCCGATGGCGATTTCAATGCTTGCATCCAAGTCTGTGAATGTAAAGCCCTTG GTCACCCATCGGTTTCCTCTGGAGAAAGCTCTGGAGGCCTTTGAAACATCCAAAAAGGGT TTGGGGTTGAAAGTCATGATCAAGTGTGACCCCAACGACCAGAATCCATGA 356 38099.0 7.5 None >Sorbitol dehydrogenase MAAAKPENLSLVVHGPGDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFV VKKPMVLGHEASGTVVKVGSLVRHLQPGDRVAIEPGAPRETDEFCKIGRYNLSPTIFFCA TPPDDGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGA GPIGLVSLLAAKAMGAAQVVVTDLSASRLSKAKEVGADFILQISNESPQEIAKKVEGLLG SKPEVTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYC NTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMIKCDPNDQNP AAX46613.1 Q58D31 DHSO_BOVIN 1PL8 BT021766 SORD