| Identification |
|---|
| BMDB Protein ID
| BMDBP00788 |
| Secondary Accession Numbers
| None |
| Name
| Short-chain specific acyl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACADS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627). |
| Pathways
|
- Butyrate Metabolism
- Fatty Acid Metabolism
- Lipid metabolism
- Mitochondrial Beta-Oxidation of Short Chain Saturated Fatty Acids
- Mitochondrial fatty acid beta-oxidation
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| 2-Methylbutyryl-CoA + electron-transfer flavoprotein → Tiglyl-CoA + Reduced electron-transfer flavoprotein |
details
|
| Isobutyryl-CoA + electron-transfer flavoprotein → Methacrylyl-CoA + Reduced electron-transfer flavoprotein |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| ACADS |
| Gene Sequence
|
>1239 bp
ATGGCTGCCACGCTGCTCGCCCGGGCCTGTGGCCTTGTCCGCGGAGCCCCCTGGCCTTGG
GGCTGGCGTCGCCTACATACCGTCTACCAGTCTGTTGAACTGCCCGAGACTCACCAGATG
CTGCGGCAGACGTGCCGCGACTTTGCCGAGAAGGAGCTCTTTCCCATCGCAGCCCAGGTG
GACAAGGAGCATCGCTTCCCAGCAGCTCAGGTGAAGAAGATGGGCGAGCTGGGGCTTATG
GCCATGAATGTGCCCGAGGAGCTCAGCGGAGCCGGCCTTGATTACCTGGCCTACTCCATC
GCCATGGAGGAGATCAGCCGGGGCTGTGCCTCCACGGGAGTCATCATGAGTGTCAACAAT
TCCCTCTACTTAGGGCCCATCCTGAAGTTCGGCACCAAGGAGCAGAAGCAGCAGTGGGTT
GCTCCCTTCACTAGTGGTGACAAAATTGGCTGCTTTGCCCTCAGTGAACCAGGGAACGGC
AGCGACGCAGGGGCCGCGGCCACCACCGCGCGGGCAGACGGTGACTCGTGGGTCCTGAGT
GGCACCAAGGCCTGGATCACCAACGCCTGGGAGGCCTCGGCCGTAGTGGTCTTCGCCAGC
ACCGACAGATCCTTGCATAACAAGGGCATCAGTGCCTTCCTGGTCCCCATGCCCACACCC
GGCCTCACGCTGGGGAAGAAGGAAGACAAGCTGGGCATCCGGGCCTCGTCCACGGCCAAC
CTCATCTTCGAGGACCGTCGCATCCCCAAGGACAGCCTGCTGGGGGAGCCGGGGCTGGGC
TTCAAGATCGCCATGCAAACCCTGGACACGGGCCGCATCGGCATCGCCTCCCAGGCCCTG
GGCATTGCCCAGGCCGCCCTGGACTGTGCTGTGACCTACGCGGAGAACCGCAGTGCTTTC
GGGGCGCCCCTCACCAAGCTGCAGGCCATCCAGTTCAAGTTGGCGGACATGGCCCTCGCC
CTGGAGAGTGCCCGGCTGCTGACCTGGCGCGCTGCCATGCTGAAGGACAACAAAAAGCCT
TTCACCAAGGAGGCGGCAATGGCCAAGCTGGCTGCATCGGAGGCCGCAACTGCCATCACC
CACCAGGCCATGCAGATCCTGGGCGGCATGGGCTACGTGAAGGAGATGCCAGCCGAGCGG
CACTACCGCGACGCCCGCATCACCGAGATTTATGAAGGCACCAGTGAGATCCAGAGGCTC
GTGGTCGCCGGGCACCTGCTCAAGAGCTACCGGAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 44552.0 |
| Theoretical pI
| 8.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Short-chain specific acyl-CoA dehydrogenase, mitochondrial
MAATLLARACGLVRGAPWPWGWRRLHTVYQSVELPETHQMLRQTCRDFAEKELFPIAAQV
DKEHRFPAAQVKKMGELGLMAMNVPEELSGAGLDYLAYSIAMEEISRGCASTGVIMSVNN
SLYLGPILKFGTKEQKQQWVAPFTSGDKIGCFALSEPGNGSDAGAAATTARADGDSWVLS
GTKAWITNAWEASAVVVFASTDRSLHNKGISAFLVPMPTPGLTLGKKEDKLGIRASSTAN
LIFEDRRIPKDSLLGEPGLGFKIAMQTLDTGRIGIASQALGIAQAALDCAVTYAENRSAF
GAPLTKLQAIQFKLADMALALESARLLTWRAAMLKDNKKPFTKEAAMAKLAASEAATAIT
HQAMQILGGMGYVKEMPAERHYRDARITEIYEGTSEIQRLVVAGHLLKSYRS
|
| External Links |
|---|
| GenBank ID Protein
| AAI03366.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBF6 |
| UniProtKB/Swiss-Prot Entry Name
| ACADS_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC103365 |
| GeneCard ID
| ACADS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
