| Identification |
|---|
| BMDB Protein ID
| BMDBP00820 |
| Secondary Accession Numbers
| None |
| Name
| A disintegrin and metalloproteinase with thrombospondin motifs 4 |
| Synonyms
|
Not Available
|
| Gene Name
| ADAMTS4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Cleaves aggrecan at the '392-Glu-|-Ala-393' site. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| ADAMTS4 |
| Gene Sequence
|
>2520 bp
ATGTCCCACATGGACTCGCATCCCGGGAGGGGCTTGGCGGACGGCTGGCTGTGGGGAATC
CAACCCCGCCTGCTGCTCCCCACTGTGCCCGTCTCCGGCTCCAGGCTAGTGTGGCTGCTG
CTGCTAGCCTCCCTCCTGCCCTCAGCCTGGCCGGCCAGCCCCCTCCCCCGGGAGGAGGAG
ATCGTGTTTCCAGAGAAGCTCAACGGCAGCGTCCTGCCTGGTTTGGGCGCCCCTGCCAGG
CTGTTGTACCGCTTGCCAGCCTTTGGGGAGACGCTGCTGCTAGAGCTGGAGAAGGACCCC
GGCGTGCAGGTTGAGGGGCTGACGGTGCAATACTTGGGCCGAGCGCCTGAGCTGCTAGGT
GGGGCGGAGCCAGGCACCTACCTCACCGGCACCATCAACGGAGATCCGGAGTCGGTGGCA
TCTCTGCACTGGGACGGGGGAGCACTTTTAGGGGTGCTGCAGTACCGAGGGACTGAACTC
CACATCCAGCCCCTGGAGGGAGGCGCGCCTAACTCCGCTGGGGGGCCTGGGGCTCACATC
CTACGCCGGAAGAGTCCTGTCAGCGGCCAGGGCCCCATGTGCAACGTCAAGGCTCCTCCT
GGGAAACCCAGCCCCAGCCCCCGAAGGGCTAAGCGCTTTGCCTCACTGAGCAGATTTGTG
GAGACTCTGGTGGTGGCAGATGACAAGATGGCGGCATTCCATGGTGCAGGGCTCAAGCGC
TACCTGCTGACAGTTATGGCAGCGGCGGCCAAGGCCTTCAAGCACCCGAGCATCCGCAAC
CCCGTCAGCTTGGTGGTGACTCGGCTAGTGGTTCTGGGGCCAGGTGAGGAAGGGCCCCAA
GTGGGCCCCAGTGCCGCCCAGACCCTGCGCAGCTTCTGTGCCTGGCAACGAGGACTCAAC
ACCCCTGACGACGCGGACCCTGGCCACTTTGACACAGCCATTCTGTTTACCCGGCAGGAC
CTGTGCGGAGTTTCTACCTGTGACACTCTAGGCATGGCTGACGTGGGCACCGTGTGTGAC
CCTGCCCGGAGCTGCGCCATTGTGGAGGATGATGGGCTGCAGTCAGCTTTCACCGCTGCT
CATGAACTGGGCCATGTCTTCAGCATGCTCCATGACAACTCGAAGCAATGCACTGGTCTG
AATGGGCCTGAGAGCACCTCCCGCCACGTCATGGCTCCTGTGATGGCTCACGTGGATCCC
GAGGAGCCCTGGTCCCCCTGCAGCGCCCGCTTCATCACTGACTTCCTAGACAATGGCTTC
GGGCACTGTCTCCTAGACAAGCCGGAGGCTCCTCTGCATCTGCCCGTGACCTTCCCCGGC
AAGGACTACGACGCTGACCGCCAGTGCCAGCTGACCTTTGGGCCTGACTCGCGCCATTGT
CCACAGCTGCCGCCGCCCTGTGCTGCCCTCTGGTGCTCTGGCCATCTGAATGGCCATGCC
ATGTGCCAGACTAAGCACTCACCCTGGGCCGACGGTACCCCTTGCGGGCCCGCACAGGCT
TGTATGGGTGGCCGCTGCCTCCATGTGGACCAGCTCCAGGCTTTCAATGTCCCACAGGCT
GGTGGCTGGGGTCCCTGGGGATCGTGGGGTGACTGCTCTCGGAGCTGTGGGGGTGGTGTC
CAGTTCTCTTCCCGGGACTGCACACGGCCCGTCCCCCGGAATGGTGGCAAGTACTGTGAG
GGCCGCCGTACCCGCTTCCGTTCCTGCAACACCCAGGACTGCCCAACTGGCTCAGCACTG
ACCTTCCGCGAAGAGCAGTGTGCTGCCTACAACCACCGCACTGACCTCTTCAAGAACTTC
CCCGGGCCCATGGACTGGGTTCCTCGCTACACTGGTGTGGCCCCCCGGGACCAGTGCAAA
CTCACCTGCCAGACCCGGGCACTGGGCTACTATTACGTGCTGGACCCACGGGTGGCAGAT
GGGACCCCCTGTTCCCCGGACAGCTCCTCAGTCTGTGTCCAGGGCCGCTGCATCCATGCC
GGCTGTGACCGCGTCATTGGCTCCAAAAAGAAGTTCGACAAGTGCATGGTGTGTGGTGGG
GATGGTTCCAGCTGCAGCAAGCAGTCTGGCTCCTTCAAAAAATTCAGGTACGGATACAAC
AACGTGGTCACCATCCCCGCTGGGGCCACCCACATCCTGGTGCGACAGCAGGGGAGCCCT
AGCGTCCGGAGCCTCTACCTGGCCCTGAAGCTCCCCGATGGCTCCTATGCCCTCAACGGT
GAATACACGCTGATCCCGTCCCCCACAGACGTGGTACTGCCCGGGGCCGTCAGCCTGCGC
TACAGCGGGGCCACTGCAGCCTCGGAGACACTGTCAGGACACGGGCCCCTGGCTGAGCCC
TTAACGCTGCAGGTCCTAGTGGCTGGCAACCCGCAGAACGCCCGCCTCAGATACAGCTTC
TTCGTGCCGCGACCGCGACCGGTCCCCTCCACGCCACGCCCCACTCCCCAGGACTGGCTG
CGCCGCAAGTCACAGATTCTGGAGATCCTCCGGCGGCGCTCCTGGGCCGGCAGGAAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 839 |
| Molecular Weight
| 90280.0 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>A disintegrin and metalloproteinase with thrombospondin motifs 4
MSHMDSHPGRGLADGWLWGIQPRLLLPTVPVSGSRLVWLLLLASLLPSAWPASPLPREEE
IVFPEKLNGSVLPGLGAPARLLYRLPAFGETLLLELEKDPGVQVEGLTVQYLGRAPELLG
GAEPGTYLTGTINGDPESVASLHWDGGALLGVLQYRGTELHIQPLEGGAPNSAGGPGAHI
LRRKSPVSGQGPMCNVKAPPGKPSPSPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKR
YLLTVMAAAAKAFKHPSIRNPVSLVVTRLVVLGPGEEGPQVGPSAAQTLRSFCAWQRGLN
TPDDADPGHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAA
HELGHVFSMLHDNSKQCTGLNGPESTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGF
GHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHA
MCQTKHSPWADGTPCGPAQACMGGRCLHVDQLQAFNVPQAGGWGPWGSWGDCSRSCGGGV
QFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTQDCPTGSALTFREEQCAAYNHRTDLFKNF
PGPMDWVPRYTGVAPRDQCKLTCQTRALGYYYVLDPRVADGTPCSPDSSSVCVQGRCIHA
GCDRVIGSKKKFDKCMVCGGDGSSCSKQSGSFKKFRYGYNNVVTIPAGATHILVRQQGSP
SVRSLYLALKLPDGSYALNGEYTLIPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAEP
LTLQVLVAGNPQNARLRYSFFVPRPRPVPSTPRPTPQDWLRRKSQILEILRRRSWAGRK
|
| External Links |
|---|
| GenBank ID Protein
| AAP47196.1 |
| UniProtKB/Swiss-Prot ID
| Q9TT93 |
| UniProtKB/Swiss-Prot Entry Name
| ATS4_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF516915 |
| GeneCard ID
| ADAMTS4 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
