| Identification |
|---|
| BMDB Protein ID
| BMDBP00828 |
| Secondary Accession Numbers
| None |
| Name
| DNA-(apurinic or apyrimidinic site) lyase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| APEX2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| APEX2 |
| Gene Sequence
|
>1545 bp
ATGTTGCGCTTGGTGAGCTGGAACATCAATGGGATACGGAGCCCCTTGCAAGGGGTGAGA
TGCGAGGAGCCCAGCAGCTGCAGCGCCATGGCTATGGGGCGCATTTTGGACAAGCTGGAT
GCAGACATCGTCTGTCTTCAGGAGACCAAAGTGACCAGGGATGTGCTGACAGAGCCCCTG
GCTATCATTGAGGGCTACAACTCCTATTTCAGCTTCAGCCGTAACCGCAGTGGCTATTCT
GGTGTAGCCACTTTCTGTAAGGACAGTGCTACCCCAGTGGCTGCTGAAGAAGGCCTGAGT
GGCCTGCTTTCCACTCAGAATGGGGATGTGGGTTGCTATGGAAACATGGATGACTTCACC
CAAGAGGAACTTCGAGCTCTGGATAGTGAGGGCCGGGCCCTCCTCACACAACACAAAATC
TGCACATGGGAAGGGAAGGAGAAGACCTTGACCCTAATCAACGTGTACTGCCCCCATGCG
GACCCTGGGAAGCCTGAGCGACTCACCTTTAAGATGCGCTTCTATCGCTTGCTGCAGATC
CGAGCAGAAGCTCTCCTGGCAGCTGGCAGCCATGTTATCATTCTGGGTGATCTGAATACA
GCCCACCGCCCCATTGATCACTGGGATGCAGTCAACATGGAATGCTTTGAAGAGGACCCA
GGGCGCAAGTGGATGGATGGTTTGCTCAGTAACCTGGGGTGTGAGAGTGGCTCCCACATG
GGACCCTTCATCGATAGCTACCGCTGCTTCCAGCCAAAGCAGAAGGGGGCCTTCACCTGT
TGGTCAACAGTCAGTGGTGCCCGCCATTTGAACTATGGCTCCCGGCTTGACTACGTGTTG
GGGGATAGGACCCTGGTCATAGACACCTTTCAGTCTTCCTTCTTGCTGCCTGAGGTGATG
GGCTCTGATCACTGCCCTGTGGGTGCAGTCTTAAGCGTGTCCTCTGTGCCAGCAAAACAG
TGCCCACCTCTGTGCACCTGCTTCCTCCCTGAGTTTGCAGGTACCCAACTCAAGATCCTA
CGATTCCTGGTTCACTTCAAACAAGATCCTGTGTTCAAGCAGTCAGCACTTCAGCCCAGC
AATCAAACACAGGTACACATGCGCAAAAACAAAGCCCGTGTGCGCTCAACTAGGTCCCGG
CCAAGTAAAACTGGCTCCAGTAGAGGCCAAAAAAACCTGATGAGCTACTTCCAGCCATCC
TCCAGTGGCCCCCAAACTTCTAACTTGGATCTTCCTAGCCTGGGCACCCTTATAACCCCA
AAGACCTCAGAAGAGGATGTGATGGCCAATGTGGTGGAGGGGCAGACCAAGGCTTCAGAG
GCCAAGGATGAAAAGGAGATACGGACCTCATTCTGGAAGTCTCTGCTGGGGGGACCCTCG
CCCATGCCCCTCTGTGGGGGACACAGGGAGCCATGTGTAATGCGAACTGTAAAGAAGCCA
GGACCCAACCTGGGCCGCCACTTCTACATGTGTGCCAGGCCCCAGGGTCCTCCCACTGAC
CCCTCTTCCCGCTGCAATTTCTTCCTCTGGAGCAGGCCCAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 514 |
| Molecular Weight
| 56938.0 |
| Theoretical pI
| 8.24 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA-(apurinic or apyrimidinic site) lyase 2
MLRLVSWNINGIRSPLQGVRCEEPSSCSAMAMGRILDKLDADIVCLQETKVTRDVLTEPL
AIIEGYNSYFSFSRNRSGYSGVATFCKDSATPVAAEEGLSGLLSTQNGDVGCYGNMDDFT
QEELRALDSEGRALLTQHKICTWEGKEKTLTLINVYCPHADPGKPERLTFKMRFYRLLQI
RAEALLAAGSHVIILGDLNTAHRPIDHWDAVNMECFEEDPGRKWMDGLLSNLGCESGSHM
GPFIDSYRCFQPKQKGAFTCWSTVSGARHLNYGSRLDYVLGDRTLVIDTFQSSFLLPEVM
GSDHCPVGAVLSVSSVPAKQCPPLCTCFLPEFAGTQLKILRFLVHFKQDPVFKQSALQPS
NQTQVHMRKNKARVRSTRSRPSKTGSSRGQKNLMSYFQPSSSGPQTSNLDLPSLGTLITP
KTSEEDVMANVVEGQTKASEAKDEKEIRTSFWKSLLGGPSPMPLCGGHREPCVMRTVKKP
GPNLGRHFYMCARPQGPPTDPSSRCNFFLWSRPS
|
| External Links |
|---|
| GenBank ID Protein
| AAX08898.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9N9 |
| UniProtKB/Swiss-Prot Entry Name
| APEX2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020881 |
| GeneCard ID
| APEX2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
