<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:24:16 UTC</creation_date>
  <update_date>2020-05-20 21:04:45 UTC</update_date>
  <accession>BMDBP00848</accession>
  <secondary_accessions>
    <accession>BMDBP03062</accession>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>UGDH</gene_name>
  <general_function>Cell wall/membrane/envelope biogenesis</general_function>
  <specific_function>Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity).</specific_function>
  <pathways>
    <pathway>
      <name>Nucleotide-sugar biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>UDP-alpha-D-glucuronate biosynthesis</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000286</accession>
      <name>Uridine diphosphate glucose</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000935</accession>
      <name>Uridine diphosphate glucuronic acid</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001487</accession>
      <name>NADH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0002111</accession>
      <name>Water</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>6</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1485 bp
ATGTTTGAAATTAAGAAGATCTGCTGCATCGGTGCAGGCTATGTTGGTGGACCCACGTGT
AGTGTCATTGCTCACATGTGCCCCGAAATCAGGGTGACGGTTGTTGATATCAATGAATCA
AGAATCAATGCATGGAACTCTCCTACACTTCCTATTTATGAGCCAGGCCTAAAAGAAGTG
GTAGAATCCTGTCGAGGAAAAAATTTATTTTTTTCTACCAATATTGATGATGCCATTAAG
GAAGCTGATCTTGTGTTTATTTCTGTGAACACACCAACCAAAACCTATGGAATGGGAAAA
GGCCGTGCAGCAGATCTGAAGTATATTGAAGCTTGTGCTAGACGCATTGTGCAAAACTCA
CACGGGTACAAAATTGTGACTGAGAAAAGCACAGTCCCAGTGCGGGCAGCAGAAAGTATT
CGTCGAATATTTGATGCAAACACAAAACCCAACTTGAATTTACAGGTGCTGTCCAACCCT
GAGTTCTTGGCAGAAGGAACAGCCATCAAGGACCTGAAGAACCCAGACAGAGTACTGATT
GGAGGAGATGAAACCCCAGAGGGCCAGAGAGCTGTGCAAGCACTGTGTGCTGTGTATGAG
CACTGGGTTCCCAGAGAAAAGATCCTCACCACTAATACTTGGTCTTCAGAACTTTCCAAA
CTGACAGCAAATGCTTTTCTGGCCCAGAGAATCAGCAGCATTAATTCTATAAGTGCCCTC
TGTGAAGCAACAGGAGCTGATGTAGAAGAGGTGGCAACAGCCATTGGAATGGACCAGAGA
ATTGGAAATAAATTTCTGAAAGCCAGTGTTGGTTTTGGTGGGAGTTGCTTTCAAAAGGAT
GTTCTGAATTTGGTTTATCTCTGTGAGGCTCTAAATTTGCCTGAAGTAGCTCGTTATTGG
CAGCAGGTTATAGACATGAATGACTACCAGAGAAGGAGGTTTGCTTCCCGGATCATAGAC
AGTCTGTTTAATACAGTGACAGATAAGAAGATAGCTATTTTGGGGTTTGCTTTCAAAAAG
GACACTGGTGATACAAGAGAGTCATCTAGTATATATATTAGCAAATATTTGATGGATGAA
GGTGCACACCTCCATATATATGATCCGAAAGTACCAAGAGAACAGATAGTTGTGGATCTT
TCTCATCCAGGAGTTTCAAAGGACGACCAAGTGGCCCGGCTCGTGACCATTTCCAAAGAT
CCCTACGAAGCATGTGATGGTGCCCACGCCGTTGTGATTTGCACTGAGTGGGACATGTTT
AAGGAACTGGATTATGAACGCATTCATAAAAAAATGCTGAAACCAGCCTTTATCTTTGAC
GGACGACGTGTCCTGGACGGGCTCCACAATGAGCTACAAACCATTGGCTTCCAGATTGAA
ACAATTGGCAAGAAGGTGTCTTCAAAGAGAATTCCATATGCTCCTTCTGGTGAAATTCCA
AAGTTTAGTCTTCAGGATATGCCCAACAAGAAACCCAGAGTATAG</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>494</residue_number>
    <molecular_weight>55136.0</molecular_weight>
    <theoretical_pi>7.64</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;UDP-glucose 6-dehydrogenase
MFEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDINESRINAWNSPTLPIYEPGLKEV
VESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKGRAADLKYIEACARRIVQNS
HGYKIVTEKSTVPVRAAESIRRIFDANTKPNLNLQVLSNPEFLAEGTAIKDLKNPDRVLI
GGDETPEGQRAVQALCAVYEHWVPREKILTTNTWSSELSKLTANAFLAQRISSINSISAL
CEATGADVEEVATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYW
QQVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSIYISKYLMDE
GAHLHIYDPKVPREQIVVDLSHPGVSKDDQVARLVTISKDPYEACDGAHAVVICTEWDMF
KELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGFQIETIGKKVSSKRIPYAPSGEIP
KFSLQDMPNKKPRV</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAC64183.1</genbank_protein_id>
  <uniprot_id>P12378</uniprot_id>
  <uniprot_name>UGDH_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>AF095792</genbank_gene_id>
  <genecard_id>UGDH</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
