| Identification |
|---|
| BMDB Protein ID
| BMDBP00857 |
| Secondary Accession Numbers
| None |
| Name
| 5-oxoprolinase |
| Synonyms
|
Not Available
|
| Gene Name
| OPLAH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. |
| Pathways
|
|
| Reactions
|
| Adenosine triphosphate + Pyroglutamic acid + 2 Water → ADP + Hydrogen phosphate + L-Glutamic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 14 |
| Locus
| Not Available |
| SNPs
| OPLAH |
| Gene Sequence
|
>3867 bp
ATGGGTGGCCCGGAGGGCCGCTTCCATTTTGCCATCGACCGTGGAGGCACCTTCACAGAT
GTCTTTGCCCAGTGCCCAGGGGGGCACGTGAGGGTCCTAAAGCTGCTTTCAGAAGACCCT
GCCAACTATGTAGACGCCCCCACTGAAGGCATCCGCCGCATCCTGGAGCAGGAGGGGGGC
GTGCTGCTGCCGCGGGACCGGCCCCTGGACACCAGTCGCATCGCCAGCATCCGCATGGGC
ACCACGGTGGCGACCAATGCGCTGTTGGAACAACAGGGAGAGCGGGTGGCACTGCTGGTG
ACGCGCGGGTTCCGAGACCTGCTGCACGTGTGCACCCAGGCCCGCGCGGANCTCTTTGAC
CTGGCCGTGCCCATGCCCGAGACGCTGTACGAGGAGGTGCTGGAAGTGGACGAACGGGTG
GTGCTCTATCGAGGGGANCCGGGTGCTGGGACACCCGTGAAAGGCTGCACAGGGGACCTA
CTGGAAGTGCAGCAGCCTGTGGACCTGGGGGGCCTGCGATGGAAGCTGGAAGGTCTCCTG
TCCCGGGGCATCCGTAGCTTGGCCGTGGTGCTCATGCACTCGTACACGTGGGCCCAGCAC
GAGCAGCAGGTGGGCGCCCTGGCCCGGGAACTGGGCTTCACGCATGTGTCGCTGTCCTCG
GAGGCCATGCCCATGGTGCGCATTGTGCCCCGGGGGCACACGGCCTGTGCTGACGCCTAT
CTCACGCCCACCATCCAGCGCTACGTGCAGGGCTTCCGACGTGGCTTCCAGGGTCAGCTC
AAGGACGTGCAGGTGCTGTTCATGCGCTCCGACGGTGGGCTGGCGCCCATGGACTCCTTC
AGCGGCTCCCGCGCTGTGCTCTCCGGGCCTGCGGGGGGCGTGGTTGGTTACTCAGCCACC
ACCTACCGGGTGGAGGGCGGCCAGCCAGTCATCGGCTTTGACATGGGAGGCACGTCTACC
GACGTGAGCCGCTATGCTGGCGAGTTTGAGCATGTTTTCGAGGCCAGCACGGCTGGTGTC
ACCCTCCAGGCCCCCCAGCTGGATATCAACACTGTGGCAGCCGGTGGGGGCTCCCGCCTC
TTTTTCAGGTCGGGCCTCTTCGTGGTGGGGCCAGAGTCTGCGGGAGCCCACCCTGGCCCC
GCCTGCTACCGAAAAGGGGGCCCTGTGACAGTGACGGATGCTAATCTGGTCCTGGGTCGC
CTGCTGCCTGCCTCCTTCCCCTGCATTTTTGGGCCGGGAGAGGACCAGCCACTGTCCCCG
GAGGCGTCCCGAAAGGCCCTGGAGGCTGTGGCCACGGAGGTCAACAGCTTCCTGACCAAT
GGGCCTTGCCCGGCCTCCCCGCTGAGCCTGGAGGAGGTGGCCATGGGGTTTGTGCGTGTG
GCCAACGAGGCCATGTGTCGGCCCATCCGTGCACTCACGCAGGCACGAGGTCATGACCCC
TCGGCCCACGTGCTGGCCTGCTTTGGGGGAGCTGGTGGGCAGCATGCTTGTGCCATTGCC
CGGGCCCTGGGCATGGACACTGTGCACATTCACAGGCACAGTGGGCTGCTGTCGGCGCTG
GGGCTGGCCCTGGCTGATGTGGTGCATGAGGCGCAGGAGCCCTGCTCCCTGCCATATGCT
CCCGAGACCTTTGCGCAGCTGGACCAGAGGCTGGGCCGCCTGGAGGAGCAGTGTGTGGAG
GCCCTGCGGGCCCAGGGCTTCCCCAGGTCCCAGATCAGCACCGAGAGCTTCCTGCACCTG
CGCTACCAGGGCACGGACTGCGCCCTGATGGTGTCTGCCCACCAGCACCCGGCCAGTGCC
CGCTCACCCCGAGCTGGTGACTTTGGGGCAGCCTTTGTGGAGAGGTACATGAGGGAGTTC
GGCTTCATTATTCCCGAGCGGCCGGTGGTGGTGGATGACGTGCGGGTCAGGGGCACCGGC
AGCAGCAGCCTTCGCCTCGAGGACGTCCCAAAAGCCCATAGTGGGCCTCCCCGGGTAGAT
AAGATGACCCAGTGCTACTTTGAGGGGGGCTACCAGGAGACCCCTGTGTACCTGTTGGGA
GAGCTGGGCTGTGGGCACAAGCTTCAGGGGCCCTGCCTCATCATTGACAGCAACAGTACC
ATCCTGGTGGAGCCAGGCTGCCAGGCAGAGGTGACTGAGACTGGGGACATCCGCATCTCT
GTGGGGGCTGAGACAGCCAGCGTGGTGGGCACGCAGCTTGACCCCATCCACCTTACCATC
TTCTCCCACCGCTTCATGAGCATTGCTGAGCAGATGGGCCGCATCCTGCAGCGCACGGCC
ATCTCCACCAACATCAAGGAGCGTCTGGACTTCTCCTGCGCCCTCTTTGGGCCCGACGGG
GGGCTGGTCTCCAACGTCCCTCACATCCCTGTGCACCTGGGTGCCATGCAGGAGACGGTG
CAGTTCCAGATTCAGCAGTTGGGGGCTGATCTCCACCCCGGCGATGTGCTGCTGAGCAAC
CACCCCAGCGCGGGGGGCAGCCACTTGCCAGACCTGACTGTCATCACACCGGTGTTTTGG
CCGGGTCAGACACGGCCTGTGTTCTATGTGGCCAGCCGTGGGCACCATGCAGACATTGGG
GGCATCACACCAGGCTCCATGCCCCCCCACTCCACCAGCCTGCAGCAGGAGGGCGCGGTC
TTCCTTTCCTTCAAACTTGTGCATGGGGGAGTCTTCCAGGAAGAGGCGGTGACTGAAGCC
CTGCGGGCGCCAGGCAAGATCCCAGGCTGCAGCGGGACACGGAACCTGCACGACAACCTG
TCGGATCTGCGCGCCCAGGTGGCGGCCAACCAGAAGGGCATCCAGCTGGTGGGCGAGCTC
ATCGGGCAGTACGGCCTGGACGTGGTGCAGGCCTACATGGGCCACATTCAGGCAAACGCG
GAGCTCGCTGTGAGGGACATGCTCCGGGCCTTTGGAACTGCCCGGCAGGCCCGGGGCCTG
CCCCTGGAGGTGTCTGCAGAGGACCACATGGACGACGGTTCCCCTATCCGACTCCGAGTG
CAGATCAACATGAGTCAGGGTAGCGCGGTGTTTGATTTCAGCGGCTCAGGGCCAGAGGTG
TTCGGCAACCTCAACGCGCCGCGGGCCATCACGCTGTCTGCGCTCATCTACTGTCTTCGC
TGTCTGGTTGGCCGCGACATCCCACTCAACCAGGGCTGCCTGGCTCCGGTGCGCGTGGTG
ATTCCTAAAGGCTCCATCCTAGACCCTTCCCCCGACGCGGCCGTGGTGGGCGGCAACGTG
CTCACGTCGCAGCGCGTGGTGGACGTCATCCTGGGGGCCTTCGGGGCCTGCGCCGCTTCC
CAGGGCTGCATGAACAACGTGACCTTGGGCAACGCCCACATGGGCTACTACGAGACGGTG
GCGGGCGGTGCGGGCGCGGGACCGGGTTGGCACGGGCGCAGCGGCGTGCACAGCCACATG
ACCAACACGCGCATCACCGACCCCGAGATCCTGGAGAGCAGGTACCCGGTTATCCTGCGC
CGCTTCGAGCTAAGGCTGGGGTCCGGGGGTCGCGGCCGCTTCCGGGGCGGCGATGGCATT
ATCCGTGAGCTGCTTTTCCGCGAGGAGGCGCTGCTGTCCGTGCTGACTGAGCGCCGCGCC
TTCCAGCCGTATGGCCTGATGGGGGGTGAGCCTGGTGCCCGGGGCCTAAACCTACTCATC
CGGAAGGACGGCCGGACAGTAAACCTGGGTGGGAAGACCTCGGTGCCCGTGTACCCCGGG
GACGTGTTCTGTCTGCACACACCAGGCGGTGGGGGCTACGGGGACCCGGGAGACCCCGCC
CCACTGCCAGGTTCGCCCTTGCAGCCCCTAGCCTTCCCGGAGAGGGGCAGCGTGTATGAG
TACCGCAGGGCCCAGGAGGCTGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1288 |
| Molecular Weight
| 137450.0 |
| Theoretical pI
| 6.55 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>5-oxoprolinase
MGGPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYVDAPTEGIRRILEQEGG
VLLPRDRPLDTSRIASIRMGTTVATNALLEQQGERVALLVTRGFRDLLHVCTQARAXLFD
LAVPMPETLYEEVLEVDERVVLYRGXPGAGTPVKGCTGDLLEVQQPVDLGGLRWKLEGLL
SRGIRSLAVVLMHSYTWAQHEQQVGALARELGFTHVSLSSEAMPMVRIVPRGHTACADAY
LTPTIQRYVQGFRRGFQGQLKDVQVLFMRSDGGLAPMDSFSGSRAVLSGPAGGVVGYSAT
TYRVEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRL
FFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGEDQPLSP
EASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDP
SAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLPYA
PETFAQLDQRLGRLEEQCVEALRAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPASA
RSPRAGDFGAAFVERYMREFGFIIPERPVVVDDVRVRGTGSSSLRLEDVPKAHSGPPRVD
KMTQCYFEGGYQETPVYLLGELGCGHKLQGPCLIIDSNSTILVEPGCQAEVTETGDIRIS
VGAETASVVGTQLDPIHLTIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDG
GLVSNVPHIPVHLGAMQETVQFQIQQLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFW
PGQTRPVFYVASRGHHADIGGITPGSMPPHSTSLQQEGAVFLSFKLVHGGVFQEEAVTEA
LRAPGKIPGCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANA
ELAVRDMLRAFGTARQARGLPLEVSAEDHMDDGSPIRLRVQINMSQGSAVFDFSGSGPEV
FGNLNAPRAITLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPKGSILDPSPDAAVVGGNV
LTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPGWHGRSGVHSHM
TNTRITDPEILESRYPVILRRFELRLGSGGRGRFRGGDGIIRELLFREEALLSVLTERRA
FQPYGLMGGEPGARGLNLLIRKDGRTVNLGGKTSVPVYPGDVFCLHTPGGGGYGDPGDPA
PLPGSPLQPLAFPERGSVYEYRRAQEAV
|
| External Links |
|---|
| GenBank ID Protein
| BAD13433.1 |
| UniProtKB/Swiss-Prot ID
| Q75WB5 |
| UniProtKB/Swiss-Prot Entry Name
| OPLA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB121737 |
| GeneCard ID
| OPLAH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
