<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:24:32 UTC</creation_date>
  <update_date>2020-05-20 21:10:54 UTC</update_date>
  <accession>BMDBP00906</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>MTHFR</gene_name>
  <general_function>Amino acid transport and metabolism</general_function>
  <specific_function>Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.</specific_function>
  <pathways>
    <pathway>
      <name>Folate Metabolism</name>
      <smpdb_id>SMP0087196</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Methionine Metabolism</name>
      <smpdb_id>SMP0087249</smpdb_id>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>One-carbon metabolism</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
    <pathway>
      <name>Tetrahydrofolate interconversion</name>
      <smpdb_id/>
      <kegg_map_id/>
    </pathway>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000217</accession>
      <name>NADP</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0000902</accession>
      <name>NAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001248</accession>
      <name>FAD</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001533</accession>
      <name>5,10-Methylene-THF</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001487</accession>
      <name>NADH</name>
    </metabolite>
    <metabolite>
      <accession>BMDB0001396</accession>
      <name>5-Methyltetrahydrofolic acid</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>16</chromosome_location>
    <locus/>
    <gene_sequence>&gt;1968 bp
ATGGTGAACGAACCCAGAGGGAACGGCAGCCCCGGCCCCCGCTGGGAGGGCAGCAGCAGC
GGCAGCGAGAGCTCAAGGACAAGTTCAAGGTGCTCCACGCCGGGGTTGGACCCCGAGCGA
TGCGAGAGACTCCGGGAGAAGATGAAGCGGAAGATGGACTCTGGAGACAAGTGGTTCTCC
CTAGAGTTCTTCCCTCCCCGAACTGCCCAGGGTGCTGTCAATCTCATCTCCAGGTTTGAC
CGGATGGGAGCGGGTGGCCCCCTCTTTGTAGACGTGACCTGGCACCCAGCCGGGGATCCT
GGCTCCGACAAGGAGACCTCGTCCATGGTGATTGCCAGCACTGCCGTGAACTACTGCGGC
CTCGAGACAATCCTGCACATGACCTGCTGCCATCAGAGCCGTGAAGAGATCACGGGCCAC
CTGAACAAAGCCAAGCAGCTGGGCCTGAAGAACATCCTGGCGCTGAGGGGAGACCCCATA
GGTGACCAATGGGAAGAGGAGGAAGGAGGCTTCAACTATGCTACGGACTTGGTGAAGCAC
ATCCGAAACGAGTTTGGTGACTACTTTGACGTCTGTGTGGCAGGTTACCCCAAAGGCCAC
CCTGAAGGAGAGAGCTTTGAGGCTGATCTGAAGCACCTGAAGGAGAAGGTGGCTGCAGGA
GCCGACTTCATCATCACCCAGCTATTCTTTGAGGCTGAAACATTCTTCCGCTTTGTGAAG
GCTTGCTCCGAGATAGGCATTACCTGCCCCGTCCTCCCCGGCATCTTCCCAATTCAGGGC
TACCACTCCCTCCGGCAGCTGGTGAAACTGTCCAAACTGGAGGTGCCACAGCAGATCAAG
GATGTGATCGAGCCCATCAAAGACAATGATGCTGCCATCCGCAACTATGGCATCGAGCAG
GCCGTGAGCCTGTGCCAGGAGCTGCTGGCCAGTGGCTTGGTTCCAGGCCTCCACTTCTAC
ACCCTCAACCGCGAGGTGGCCACCATCGAGGTGCTGAAGCGCCTGGGGCTTTGGATTGAG
GACCCTAGGCGTCCCCTGCCCTGGGCCCTCAGTGCCCACCCCAAGCGCCGGGTGGAGGAT
GTCCGGCCCATCTTCTGGGCCTCGAGACCAAAGAGTTACATTTACCGTACGCAGGAGTGG
GACGAGTTCCCCAATGGCCGCTGGGGCAATTCCTCCTCTCCGGCCTTTGGGGAGCTGAAG
GACTACTACCTCTTCTACCTAAAGAGCAAGTCCCCGAAGGAGGAGCTGCTCAAGATGTGG
GGGGAGGAGCTGACCAGTGAGGAAAGCGTCTTCCAAGTCTTTGCCCACCACCTCTCGGGA
GAGCCCAACCAGAATGGCTACAAAGTGACTTGCCTGCCCTGGAATGATGAGCCCCTGGCA
GCCGAGACCAGCCTGATGAAGGAGGAGCTGCTGAGAGTGAACCGGCGAGGCATCCTCACC
ATCAACTCCCAGCCCAACATCAACGGGAAGCCGTCCTCTGACCCCATCGTGGGCTGGGGC
CCCAGTGGGGGCTATGTCTTCCAGAAGGCCTACTTAGAGTTCTTCACTTCCCGAGAAACG
GTGGAGGCGCTTTTGCAGGTGCTGAAGAAGTATGAACTCCGGGTGAATTACCACATCGTG
GATGTGAAGGGTGAAAATATCACCAACGCCCCTGAGCTGCAACCCAACGCGGTCACCTGG
GGCATCTTCCCTGGCCGAGAGATCATCCAGCCCACAGTGGTGGACCCGGTCAGCTTCATG
TTCTGGAAGGATGAGGCCTTCGCGCTGTGGATTGAGCAGTGGGGCAAGCTGTATGAGGAG
GAGTCCCCCTCCCGCATGATCATCCAGTACATCCACGACAACTACTTCCTGGTCAACCTG
GTGGACAACGAGTTTCCGCTGGACAACTGCCTGTGGCAGGTGGTGGAAGACACGTTTGAG
CTTCTCAGCAGGCCCCCCCAAGACAAGAGGGAGACAGAGGCGCTGTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>655</residue_number>
    <molecular_weight>74485.0</molecular_weight>
    <theoretical_pi>5.1</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Methylenetetrahydrofolate reductase
MVNEPRGNGSPGPRWEGSSSGSESSRTSSRCSTPGLDPERCERLREKMKRKMDSGDKWFS
LEFFPPRTAQGAVNLISRFDRMGAGGPLFVDVTWHPAGDPGSDKETSSMVIASTAVNYCG
LETILHMTCCHQSREEITGHLNKAKQLGLKNILALRGDPIGDQWEEEEGGFNYATDLVKH
IRNEFGDYFDVCVAGYPKGHPEGESFEADLKHLKEKVAAGADFIITQLFFEAETFFRFVK
ACSEIGITCPVLPGIFPIQGYHSLRQLVKLSKLEVPQQIKDVIEPIKDNDAAIRNYGIEQ
AVSLCQELLASGLVPGLHFYTLNREVATIEVLKRLGLWIEDPRRPLPWALSAHPKRRVED
VRPIFWASRPKSYIYRTQEWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPKEELLKMW
GEELTSEESVFQVFAHHLSGEPNQNGYKVTCLPWNDEPLAAETSLMKEELLRVNRRGILT
INSQPNINGKPSSDPIVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKKYELRVNYHIV
DVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPVSFMFWKDEAFALWIEQWGKLYEE
ESPSRMIIQYIHDNYFLVNLVDNEFPLDNCLWQVVEDTFELLSRPPQDKRETEAL</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAW39033.1</genbank_protein_id>
  <uniprot_id>Q5I598</uniprot_id>
  <uniprot_name>MTHR_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>AY854631</genbank_gene_id>
  <genecard_id>MTHFR</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
