| Identification |
|---|
| BMDB Protein ID
| BMDBP00914 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A |
| Synonyms
|
Not Available
|
| Gene Name
| MGAT4A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in alpha-1,3-mannosylglycoprotein 4-beta-N-ace |
| Specific Function
| Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells. |
| Pathways
|
- Protein glycosylation
- Protein modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| MGAT4A |
| Gene Sequence
|
>1608 bp
ATGAGGCTCCGAAATGGAACTGTAGCCACTGTTTTAGCATTTATCACCTCGTTCCTCACT
TTATCTTGGTATACAACATGGCAAAATGGGAAAGAAAAAGTGATTGCTTATCAACGAGAA
TTTCTTGCTCTGAAAGAACGTCTCCGAATAGCTGAACATCGAATCTCTCAGCGCTCTTCT
GAGCTCAGTGCCATTGTACAGCAATTCAAGCGTGTAGAAGCAGAAACAAACAGGAGTAAG
GATCCAGTGAATAAATTTTCAGATGATACCCTAAAGATACTAAAGGAGTTAACAAGCAAA
AAGTCTCTTCAAGTGCCAAGTATTTATTATCATTTGCCTCATTTATTGCAAAATGAAGGA
AGCCTTCAACCTGCCGTGCAGATCGGAAATGGACGAACAGGAGTTTCAATAGTAATGGGA
ATTCCTACAGTGAAGAGAGAAGTTAAATCTTACCTCATAGAAACTCTTCATTCCCTTATT
GATAATCTGTATCCTGAAGAGAAGTTGGACTGTGTTATAGTAGTCTTCATAGGAGAGACA
GATACTGATTATGTAAATGGTGTTGTAGCCAACCTGGAGAAAGAATTTTCTAAAGAAATC
AGTTCTGGCTTGGTGGAAATAATATCACCTCCTGAAAGCTATTATCCTGACCTGACGAAC
TTAAAGGAGACATTTGGAGATTCTAAAGAAAGAGTAAGATGGAGAACAAAGCAAAACCTA
GATTATTGTTTTCTAATGATGTATGCTCAGGAAAAAGGCACATACTACATCCAGCTTGAA
GATGATATTATTGTCAAACAGAATTACTTTAACACCATAAAGAATTTTGCACTTCAACTT
TCTTCTGAGGAATGGATGATACTTGAGTTCTCCCAGCTGGGATTCATTGGTAAAATGTTT
CAAGCACCTGACCTCACTCTGATTGTGGAATTCATATTTATGTTCTATAAGGAGAAGCCC
ATCGACTGGCTCTTGGACCATATTCTGTGGGTCAAAGTCTGCAACCCGGAAAAAGATGCA
AAACACTGTGATCGACAGAAGGCAAATCTGCGAATTCGTTTCAGACCGTCCCTTTTCCAA
CACGTTGGTCTGCATTCTTCACTCACAGGAAAAATTCAGAAACTCACGGATAAAGATTAC
ATGAAACCATTACTGCTCAAAATCCATGTAAACCCCCCTGCAGAGGTATCTACTTCTTTG
AAGGTCTACCAAGGTCATACACTGGAGAAAACTTACATGGGTGAGGACTTCTTCTGGGCT
ATAACCCCAGTAGCTGGAGACTACATCCTATTTAAATTCGACAAGCCAGTCAATGTGGAA
AGTTATTTGTTCCATAGTGGCAACCAGGATCATCCAGGGGATATTCTGCTCAACACAACG
GTGGAAGTTCTGCCTTTGAAGAGTGAAGGTTTGGACATCAGCAAAGAAACCAAAGACAAA
CGATTAGAAGATGGCTATTTCAGAATAGGGAAATTTGAAAACGGTGTTGCGGAAGGGATG
GTGGATCCCAGCCTAAACCCCATTTCGGCCTTCCGACTTTCAGTTATTCAGAATTCTGCT
GTTTGGGCCATTCTTAATGAGATCCATATTAAAAAAGTCACAAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 535 |
| Molecular Weight
| 61618.0 |
| Theoretical pI
| 7.0 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
MRLRNGTVATVLAFITSFLTLSWYTTWQNGKEKVIAYQREFLALKERLRIAEHRISQRSS
ELSAIVQQFKRVEAETNRSKDPVNKFSDDTLKILKELTSKKSLQVPSIYYHLPHLLQNEG
SLQPAVQIGNGRTGVSIVMGIPTVKREVKSYLIETLHSLIDNLYPEEKLDCVIVVFIGET
DTDYVNGVVANLEKEFSKEISSGLVEIISPPESYYPDLTNLKETFGDSKERVRWRTKQNL
DYCFLMMYAQEKGTYYIQLEDDIIVKQNYFNTIKNFALQLSSEEWMILEFSQLGFIGKMF
QAPDLTLIVEFIFMFYKEKPIDWLLDHILWVKVCNPEKDAKHCDRQKANLRIRFRPSLFQ
HVGLHSSLTGKIQKLTDKDYMKPLLLKIHVNPPAEVSTSLKVYQGHTLEKTYMGEDFFWA
ITPVAGDYILFKFDKPVNVESYLFHSGNQDHPGDILLNTTVEVLPLKSEGLDISKETKDK
RLEDGYFRIGKFENGVAEGMVDPSLNPISAFRLSVIQNSAVWAILNEIHIKKVTN
|
| External Links |
|---|
| GenBank ID Protein
| BAA31162.1 |
| UniProtKB/Swiss-Prot ID
| O77836 |
| UniProtKB/Swiss-Prot Entry Name
| MGT4A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB000628 |
| GeneCard ID
| MGAT4A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
